The Influence of Hypothermia on Pancreatic Secretion and Blood Flow

Eichelter, P; Schenk, Worthington G.

doi:10.1001/archsurg.1968.01330240029007

Cited by 8 publications

(2 citation statements)

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“…Hypothermia can lead to pancreatic ischemia secondary to alterations in the cardiac output and ventilation, as well as in the pancreatic microcirculation. 7,8,12,14 During the ischemic period, xanthine dehydrogenase is converted to xanthine oxidase, and upon reperfusion xanthine reacts with oxygen yielding reactive oxyradicals. 49 It is known that, during the ischemic process, levels of antioxidants such as glutathione and superoxide dismutase are low, rendering the tissue prone to free radical lesions.…”

Section: Discussionmentioning

confidence: 99%

“…11 Furthermore, low body temperature reduces cardiac output, causing hypotension with a further decrease in pancreatic blood flow. 12,13 Hypothermia also affects oxygen dissociation from hemoglobin, 7 increases blood viscosity, induces alterations in coagulation, causing thrombosis in pancreatic vessels, 14 and may cause ventilatory dysfunction due to lower efficiency of the diaphragm. 8 In contrast, some authors found a protective effect of mild hypothermia in experimental acute pancreatitis, with less release of amylase, lipase and inflammatory cytokines in the hypothermic groups.…”

Section: Introductionmentioning

confidence: 99%

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Oxidative Stress Is Enhanced by Hypothermia Imposed on Cerulein-Induced Pancreatitis in Rats

Andraus

Jukemura

Dutra

et al. 2007

Clinics

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MC. Oxidative stress is enhanced by hypothermia imposed on cerulein-induced pancreatitis in rats. Clinics. 2007;62(4): 483-90. BACKGROUND:Hypothermia is a frequent event in severe acute pancreatitis (AP) and its real effects on the normal pancreas have not been well demonstrated. Moreover, neither have its effects on the outcome of acute pancreatitis been fully investigated. One hypothesis is that oxidative stress may be implicated in lesions caused or treated by hypothermia. Aim of the study: To investigate the effect of hypothermia in cerulein-induced acute pancreatitis (CIAP) in rats and the role played by oxidative stress in this process. METHODS: Male Wistar rats were divided into hypothermic and normothermic groups. Hypothermia was induced with a cold mattress and rectal temperature was kept at 30 o C for one hour. Acute pancreatitis was induced with 2 doses of cerulein (20 ìg/kg) administered at a one-hour interval. Serum amylase, pancreas vascular permeability by Evan's blue method, pancreas wet-to-dry weight ratio and histopathology were analyzed in each group. RESULTS: When compared with normothermic rats, hypothermic animals, with cerulein-induced acute pancreatitis, showed higher levels of pancreatic vascular permeability (P < 0.05), pancreas wet-to-dry weight ratio (P = 0.03), and histologically verified edema (P < 0.05), but similar serum amylase levels. The hypothermic group showed a higher oxidized-reduced glutathione ratio than the normothermic group. CONCLUSION: Moderate hypothermia produced a greater inflammatory response in established acute pancreatitis induced by cerulein in rats. Moreover, this study suggests that oxidative stress may be one of the mechanisms responsible for the worse outcome in hypothermic rats with cerulein-induced acute pancreatitis.

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Section: Discussionmentioning

confidence: 99%