The Influence of <i>Lactobacillus brevis</i> on Ornithine Decarboxylase Activity and Polyamine Profiles in <i>Helicobacter pylori</i>‐Infected Gastric Mucosa

Linsalata, Michele; Russo, Francesco; Berloco, P.B.; Caruso, Maria Lucia; Matteo, G. Di; Cifone, Maria Grazia; Simone, Claudio De; Ierardi, Enzo; Leo, Alfredo Di

doi:10.1111/j.1083-4389.2004.00214.x

Cited by 87 publications

(43 citation statements)

References 33 publications

(49 reference statements)

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“…Ingestion of L. gasseri strain LG21 did not eradicate H. pylori, but it decreased H. pylori density in gastric mucosa of the H. pylori-positive volunteers (15). Similar results were reported in clinical trials using L. brevis (21) and yogurt containing L. acidophilus and Bifidobacterium lactis (22). It was reported that triple therapy supplemented with inactivated culture of L. acidophilus (14) or yogurt containing Lactobacillus and Bifidobacterium (19) increased H. pylori eradication rates.…”

Section: Discussionsupporting

confidence: 71%

Probiotics and Helicobacter pylori infection

Kamiya

Takahashi²,

Manzoku³

et al. 2006

Microbial Ecology in Health and Disease

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Probiotics involving Lactobacillus, Bifidobacterium, Saccharomyces , Clostridium butyricum , etc. have been reported to have inhibitory effects on Helicobacter pylori infections in in vitro and in vivo studies. In addition, these probiotics have been reported to be effective in clinical studies; the patients treated with triple therapy combined with probiotics had a higher H. pylori eradication rate than those with triple therapy only, and antibiotic-associated gastrointestinal side effects during H. pylori eradication therapy were reduced in the patients treated with a probiotics supplemented regimen. It was also reported that probiotic supplementation reduced side effects and permitted a slight improvement in eradicating H. pylori in secondline eradication therapy.

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Section: Discussionsupporting

confidence: 71%

Probiotics and Helicobacter pylori infection

Kamiya

Takahashi²,

Manzoku³

et al. 2006

Microbial Ecology in Health and Disease

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“…Lactobacillus brevis strain showed pro-apoptotic effects in Jurkat cells and it was hypothesized that this ability in inducing apoptosis could be associated with polyamine synthesis (68). Besides, a peculiar Lactobacillus brevis strain (CD2 strain) demonstrated anti-proliferative biochemical features, essentially related to the activity of arginine deiminase (69). This enzyme is able to catalyse the catabolism of arginine and to affect the biosynthesis of polyamines (70).…”

Section: Influence Of Nutritional Factors On Polyamine Metabolism Formentioning

confidence: 99%

Pharmacological and dietary agents for colorectal cancer chemoprevention: Effects on polyamine metabolism (Review)

Linsalata¹,

Orlando²,

Russo³

2014

International Journal of Oncology

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Abstract. Chemoprevention is the long-term use of different chemical agents, both synthetic and natural, to prevent or delay the onset of disease. Since colorectal cancer has a significant environmental component, it is an ideal disease in which to evaluate the potential benefits of chemopreventive agents. The polyamines, spermine, spermidine and putrescine have been involved in almost all the steps of colorectal tumorigenesis. Consequently, polyamine biosynthesis and catabolism can be considered as promising targets for cancer chemoprevention. A variety of drug formulations have been tested for their efficacy in affecting polyamines in a strategy of colorectal cancer prevention. Different molecules, such as biosynthesis inhibitors and catabolism inducers, have been proposed alone or in combination with other drugs proved to diminish the colorectal cancer risk. Interestingly, also diet can play a role in cancer prevention by affecting polyamines. Several dietary components, such as probiotics or flavonoids, have been shown to affect the polyamine metabolic pathway in colorectal neoplastic tissue. On the other hand, the polyamines ingested with diet might contrast the above cited effects shown by both drugs and nutritional factors. It is, therefore, fundamental to acquire more data also on these aspects in view of an innovative approach to colorectal oncology. This review summarizes data on the role of polyamine metabolism in neoplastic transformation of colorectal mucosa and as possible target for colorectal cancer chemoprevention. Attention will be focused on the influence of drugs and nutritional factors on polyamine metabolism, as well as the role played by dietary polyamines.

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“…This is only one of the examples. It can be speculated that the suppression of Helicobacter pylori infection by some LAB (Wang et al, 2004;Cruchet et al, 2003;Linsalata et al, 2004) may have a certain effect on the host OxSrelated indices in blood. However, such approaches are actually only speculations.…”

Section: Role Of Probiotics For Systemic Antioxidative Defence (Possimentioning

confidence: 99%