The influence of impact delivery mode, lactation time, infant gender, maternal age and rural or urban life on total number of Lactobacillus in breast milk Isfahan - Iran

Taghizadeh, Mansoureh; Mirlohi, Maryam; Poursina, Farkhondeh; Madani, Golnoush; Khoshhali, Mehri; Esfahani, Nimah Bahreini; Safaei, Hajieh Ghasemian

doi:10.4103/2277-9175.161546

Cited by 14 publications

(7 citation statements)

References 32 publications

(53 reference statements)

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“…We argue these associations with the infant fecal microbiota could have been introduced through differential composition of the maternal colostrum and breast milk. Inclinations for higher median counts of total cultivable lactobacilli in breast milk of women living in the rural areas compared with those from urban areas were also reported previously 42 , 43 . Moreover, lactobacilli and bifidobacteria were less frequently found in the breast milk of women on prior antibiotic therapy during pregnancy and lactation 44 .…”

Section: Discussionsupporting

confidence: 74%

Microbes in Infant Gut Development: Placing Abundance Within Environmental, Clinical and Growth Parameters

Obermajer

Grabnar

Benedik

et al. 2017

Sci Rep

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Sound and timely microbial gut colonization completes newborn’s healthy metabolic programming and manifests in infant appropriate growth and weight development. Feces, collected at 3, 30, and 90 days after birth from 60 breastfed Slovenian newborns, was submitted to microbial DNA extraction and qPCR quantification of selected gut associated taxa. Multivariate regression analysis was applied to evaluate microbial dynamics with respect to infant demographic, environmental, clinical characteristics and first year growth data. Early microbial variability was marked by the proportion of Bacilli, but diminished and converged in later samples, as bifidobacteria started to prevail. The first month proportions of enterococci were associated with maternity hospital locality and supplementation of breastfeeding with formulae, while Enterococcus faecalis proportion reflected the mode of delivery. Group Bacteroides-Prevotella proportion was associated with infant weight and ponderal index at first month. Infant mixed feeding pattern and health issues within the first month revealed the most profound and extended microbial perturbations. Our findings raise concerns over the ability of the early feeding supplementation to emulate and support the gut microbiota in a way similar to the exclusively breastfed infants. Additionally, practicing supplementation beyond the first month also manifested in higher first year weight and weight gain Z-score.

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Section: Discussionsupporting

confidence: 74%

Microbes in Infant Gut Development: Placing Abundance Within Environmental, Clinical and Growth Parameters

Obermajer

Grabnar

Benedik

et al. 2017

Sci Rep

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“…Влияние социальной среды, культуры, гигиенических привычек, плотности населения (сельской местности или города) широко обсуждается. По сообщению M. Taghizadeh et al из Ирана, проживание в сельской местности положительно отражается на содержании в грудном молоке женщин Lactobacillus [39]. В грудном молоке сельских женщин из Индии оказались не характерные для городских жительниц Alphaproteobacteria, Betaproteobacteria, Actinobacteria [40].…”

Section: Discussionunclassified

“…Есть также данные количественных измерений. У иранских женщин молоко для мальчиков оказалось богато Lactobacillus [39], а J.E. Williams et al подсчитали, что уровень Streptococcus в молоке матерей мальчиков выше, а Staphylococcus -ниже, чем в молоке матерей девочек (51,7 ± 4,2% по сравнению с 36,0 ± 5,6%, 19,2 ± 3,7% по сравнению с 34,7 ± 6,1% соответственно; р < 0,05) [28].…”

Section: Discussionunclassified

“…Молоко иранских женщин после 3 мес. лактации содержало значительно меньше лактобактерий [39]. A. Ojo-Okunola et al сообщили, что у матерей старшего возраста индекс разнообразия выше, чем у молодых [48], что кажется вполне логичным.…”

Section: Discussionunclassified

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Breast milk microbiota of healthy women living in the Russian Federation

Kuchina,

Zakharova,

Odintsova

et al. 2024

Medicinskij sovet

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Introduction. Mother’s breast milk is considered to be the best source of infant nutrition and, paradoxical as it may sound, the only product of the infant diet, which composition is still poorly known to us. This article presents the findings of a study on the breast milk microbiota conducted in the Russian Federation for the first time.Aim. To study the composition of the breast milk microbiota of healthy women living in the Russian Federation and identify the impact of various factors on its diversity.Materials and methods. A molecular genetic study on 56 colostrum samples and 12 mature breast milk samples from 56 healthy donors using a method based on sequencing of bacterial 16S rRNA gene was conducted.Results. In a batch of 56 colostrum samples, 22 species and 242 genera of bacteria were identified. Firmicutes, Proteobacteria, Actinobacteriota were the most predominant species of bacteria in healthy women with a normal body mass index, from a physiological pregnancy, who did not take antibiotics, after natural delivery at term; Streptococcus, Staphylococcus and Gemella were the most predominant at the level of delivery. Statistical analysis of the impact of nationality, age, number of children in the family and duration of hospitalization (PERMANOVA) showed no significant differences in the proportions of bacteria in the colostrum of women (p > 0.05). The gender of the child was the only factor that turned out to be significant. The biodiversity of colostrum of girl-delivered mothers were higher (Shannon index) than that of boy-delivered mothers. In addition, the mature breast milk microbiota (1 month after delivery) has lower alpha diversity as compared to colostrum.Discussion. The analysis of our results and reports from foreign colleagues showed significant similarities and differences, which, certainly, were explained by a number of reasons related to methodological and geographical differences, the method, timing and even the time of day when breast milk samples were collected.Conclusion. In general, the colostrum of healthy women had a fairly stable bacterial composition, and its rich biodiversity fully demonstrated high quality of the first microbial inoculum for the newborn intestine. Our results provide valuable insights into the healthy breast milk microbiota in women living in the Russian Federation and can be used as reference ranges, as well as for comparison with similar indicators in women from other countries.

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“…Infants born by C-section display a bacteria strains more similar to human skin microbiota. However, the skin flora is no more related of mother than of a stranger, what indicates that most bacteria are transmitted to the infant from those handling the newborn [5], with underrepresentation of enteric species, such as Bacteroides and Escherichia-Shigella [22]. In breastfed children, the predominant flora of the gastrointestinal tract contains bacteria of the Bifidobacterium and Lactobacillus genera, with limited potential pathogens such as Streptococcus spp.…”

Section: Bioactive Agentsmentioning

confidence: 99%

Breast milk – a living superfood. Review of current knowledge

Figurowska,

Małek,

Emerla

et al. 2024

J Educ Health Sport

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Introduction: Breastfeeding is considered the best nutrition for infants, including born preterm due to containing optimal ingredients for development and growth. Breast milk is a rich source of nutrients, it also contains diverse types of bacteria, which play a role in infant’s gastrointestinal tract colonization and preserving mammary health. Composition of human milk varies depending on numerous maternal and infant factors. Aim of the study: The aim of the study was to summarize the current knowledge about the content of nutrients, bioactive factors and microbiota diversity in human milk depending on various factors. Materials and methods: The work is a review of 26 mainly English-language scientific publications from 1989-2024 posted on the PubMed platform. Results: Milk composition changes in addition to several factors. Depending on postnatal age: preterm milk has higher content of protein, fat and immunological factors and lower concentration of lactose than term milk. Depending on milk maturity: Colostrum is higher in protein but lower in lactose, fat and energy than mature milk. Human milk is also a source of viable bacteria important for developing infant’s gut microbiota, but the diversity of bacterial strains in milk may vary. Depending on mode of delivery: milk of mothers after spontaneous labour contents more probiotic vaginal- and enteric-associated bacteria, while milk of mothers after C-section has more skin-associated microbiota. Depending on mother’s weight: milk of overweight mothers is lower in probiotic- and higher in pathogenic bacteria. Alcohol, nicotine, and some medications also have negative impact on produced milk. Conclusions: Human milk varies from woman to woman and its composition depends on several factors. Postnatal and gestational stage, delivery mode, mother's weight and certain substances have been found to be important factors influencing the constitution of breast milk, including nutrients, microbiota and volume of milk.

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The influence of impact delivery mode, lactation time, infant gender, maternal age and rural or urban life on total number of Lactobacillus in breast milk Isfahan - Iran

Cited by 14 publications

References 32 publications

Microbes in Infant Gut Development: Placing Abundance Within Environmental, Clinical and Growth Parameters

Microbes in Infant Gut Development: Placing Abundance Within Environmental, Clinical and Growth Parameters

Breast milk microbiota of healthy women living in the Russian Federation

Breast milk – a living superfood. Review of current knowledge

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