The influence of in vitro pectin fermentation on the human fecal microbiome

Bang, So-Jung; Kim, Gayoung; Lim, Mi Young; Song, Eun-Ji; Jung, Dong-Hyun; Kum, Jun-Seok; Nam, Young-Do; Park, Cheon-Seok; Seo, Dong-Ho

doi:10.1186/s13568-018-0629-9

Cited by 102 publications

(70 citation statements)

References 49 publications

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“…Dialister , for example, was found in higher abundance linked to consumption of dietary fiber from whole-grain or soluble corn fiber (47). Sutterellaceae was increased in in vitro citrus pectin fermentation (45). Bilophila , a bile-tolerant micro-organism, was found in increased abundance associated with consumption of an animal-based diet and milk fat (18, 48).…”

Section: Discussionmentioning

confidence: 99%

Hass Avocado Inclusion in a Weight-Loss Diet Supported Weight Loss and Altered Gut Microbiota: A 12-Week Randomized, Parallel-Controlled Trial

Henning

Yang

Woo

et al. 2019

Current Developments in Nutrition

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Background Avocados contain fiber, lutein, and vitamin E, and they are a rich source of MUFAs. The effect of including an avocado daily as part of a hypocaloric weight-loss diet on weight loss is not known. Objective The aim of this study was to determine the effect of daily avocado consumption as part of a hypocaloric diet on weight loss, body composition, satiety, biomarkers of inflammation, and intestinal microbiota composition. Methods In this randomized, parallel-controlled, open-label, 2-arm intervention study, 51 healthy overweight/obese women and men were assigned to a hypocaloric diet with 1 Hass avocado daily (AVO; n = 24) or a hypocaloric diet (CTRL; n = 27) without daily avocado for 12 wk. Serum markers and intestinal microbiota were analyzed at baseline and week 12. Results Both groups experienced significant weight loss, decrease in BMI (in kg/m2), total body fat, and visceral adipose tissue, respectively (AVO: −2.3 ± 2 kg, −0.8 ± 0.8, −1.1% ± 2%, and −81.2 ± 118 g; CTRL: −2.6 ± 3.6 kg, −0.9 ± 1, −1.5% ± 2%, and −87.4 ± 216 g). We observed a significant decrease in serum glucose over time in the control group compared with the AVO group. There was no change between the groups in serum triglyceride, but a significant decrease from baseline to 12 wk was observed in the AVO group. Serum hepatic growth factor (HGF) and relative proportion of bacterial phyla (Firmicutes and Bacteroidetes), family (Bacteroidaceae and Erysipelotrichaceae), and genus (Bacteroides, Clostridium, Methanosphaera, and Candidatus Soleaferrea) were significantly altered in the AVO group compared with the CTRL group. A trend to decrease in serum inflammatory factors IL-1β (P = 0.07) and C-reactive protein (P = 0.074) was observed in the AVO group compared with CTRL. Conclusions Daily Hass avocado consumption as part of a hypocaloric diet supported weight loss, a decrease in serum HGF, and an increase in the abundance of bacteria involved in plant polysaccharide fermentation. This trial was registered at clinicaltrials.gov as NCT02953158.

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Section: Discussionmentioning

confidence: 99%

Hass Avocado Inclusion in a Weight-Loss Diet Supported Weight Loss and Altered Gut Microbiota: A 12-Week Randomized, Parallel-Controlled Trial

Henning

Yang

Woo

et al. 2019

Current Developments in Nutrition

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“…At the genus level, Bacteroides , Lachnospira , Streptococcus and Klebsiella were the dominant bacteria in the BHI group in LEfse analysis. Bacteroides is one of the most abundant genera in the gut and has a positive correlation with propionic acid production (Nakano et al 2013), and Lachnospira also plays an important role in SCFA production (Bang et al 2018). Previous studies have reported that Streptococcus and Klebsiella were widely distributed in the human skin, mouth and intestine, and Streptococcus can degrade digested proteins into peptides in human gut (Macfarlane et al 1988; Sekirov et al 2010; Brisse et al 2006).…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the effects of four media on human intestinal microbiota culture in vitro

Chen

Zhang

et al. 2019

AMB Expr

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The human intestinal microbiota has an important role in the maintenance of human health and disease pathogenesis. The aim of this research was to investigate the impact of four media on human intestinal microbiota metabolite and composition changes, we performed in vitro batch culture using intestinal microbiota samples from three fecal microbiota transplantation (FMT) donors. After 48 h culture, gut microbiota medium (GMM) had the highest production of acetic acid (73.00 ± 7.56 mM) and propionic acid (16.79 ± 1.59 mM), bacterial growth media (BGM) had the highest production of butyric acid (13.39 ± 0.56 mM). In addition, brain heart infusion (BHI) promoted (p < 0.05) the growth of Bacteroidetes , especially Bacteroides after 48 h, GMM resulted in a significant increase (p < 0.05) in Actinobacteria and increased the beneficial genus Bifidobacterium , fastidious anaerobe broth (FAB) increased Firmicutes population, and BGM promoted the growth of Escherichia – Shigella and Akkermansia . The results suggest that four media had different effects on the human intestinal microbiota metabolism and composition in vitro. These results may facilitate the culture of bacteria from the human intestinal microbiota.

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“…The most extensively studied fruit fiber prebiotic component is pectin, which comprises on average 35% of fruit fiber cell wall content [9,37]. A Korean in vitro human colonic microbiota model system study (3 male donors with diverse microbiota profiles) confirmed the effectiveness of pectin in promoting robust prebiotic activity in all subjects [39]. Although donors had differences in baseline colonic microbiota composition, there were similar increases in healthy bacteria after pectin fermentation including species belonging to butyrate producing Clostridium cluster XIV (e.g., Lachnospira ), and Sutterella .…”

Section: Fruit As a Prebiotic Sourcementioning

confidence: 99%

Whole Fruits and Fruit Fiber Emerging Health Effects

2018

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Less than 10% of most Western populations consume adequate levels of whole fruits and dietary fiber with typical intake being about half of the recommended levels. Evidence of the beneficial health effects of consuming adequate levels of whole fruits has been steadily growing, especially regarding their bioactive fiber prebiotic effects and role in improved weight control, wellness and healthy aging. The primary aim of this narrative review article is to examine the increasing number of health benefits which are associated with the adequate intake of whole fruits, especially fruit fiber, throughout the human lifecycle. These potential health benefits include: protecting colonic gastrointestinal health (e.g., constipation, irritable bowel syndrome, inflammatory bowel diseases, and diverticular disease); promoting long-term weight management; reducing risk of cardiovascular disease, type 2 diabetes and metabolic syndrome; defending against colorectal and lung cancers; improving odds of successful aging; reducing the severity of asthma and chronic obstructive pulmonary disease; enhancing psychological well-being and lowering the risk of depression; contributing to higher bone mineral density in children and adults; reducing risk of seborrheic dermatitis; and helping to attenuate autism spectrum disorder severity. Low whole fruit intake represents a potentially more serious global population health threat than previously recognized, especially in light of the emerging research on whole fruit and fruit fiber health benefits.

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The influence of in vitro pectin fermentation on the human fecal microbiome

Cited by 102 publications

References 49 publications

Hass Avocado Inclusion in a Weight-Loss Diet Supported Weight Loss and Altered Gut Microbiota: A 12-Week Randomized, Parallel-Controlled Trial

Hass Avocado Inclusion in a Weight-Loss Diet Supported Weight Loss and Altered Gut Microbiota: A 12-Week Randomized, Parallel-Controlled Trial

Evaluation of the effects of four media on human intestinal microbiota culture in vitro

Whole Fruits and Fruit Fiber Emerging Health Effects

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