The influence of inosiplex treatment on the neurological disability of patients with subacute sclerosing panencephalitis

DuRant, Robert H.; Dyken, Paul R.; Swift, Andrea V.

doi:10.1016/s0022-3476(82)80143-1

Cited by 47 publications

(10 citation statements)

References 19 publications

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“…However, the slowly developing SSPE-treated group had significantly lower neurological disability than did the slowly developing untreated group from 2Y2-4Y2 years after onset of SSPE. 2 These findings agree with Huttenlocher and Mattson's conclusion that inosiplex appears to be more effective in patients with slowly developing or chronic forms of SSPE, but may be beneficial in all patients with SSPE.…”

Section: Trea Tment Of Sspesupporting

confidence: 90%

Treatment of Subacute Sclerosing Panencephalitis: An Overview

Taylor¹,

DuRant²,

Dyken³

1984

Drug Intelligence & Clinical Pharmacy

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Subacute sclerosing panencephalitis (SSPE) is a rare central nervous system degenerative disease that occurs primarily in children and adolescents. It is believed to be caused by a measles-like virus. Initial symptoms usually present as a variety of personality changes followed by myoclonus with progression of mental and motor deterioration, which leads to death within a few months to years. New experimental treatment with inosiplex has been shown to be helpful for patients stricken with this progressive neurological disease. A response to inosiplex therapy is best in patients with a slowly progressing form of the disease. Inosiplex treatment is safe with few adverse effects. The duration of treatment appears to be lifelong since many patients relapse when inosiplex therapy is discontinued. This article reviews the etiology, pathogenesis, and experimental treatment of SSPE.

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Section: Trea Tment Of Sspesupporting

confidence: 90%

Treatment of Subacute Sclerosing Panencephalitis: An Overview

Taylor¹,

DuRant²,

Dyken³

1984

Drug Intelligence & Clinical Pharmacy

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“…Because they often had no clinically diagnostic signs, there was a concern that these patients might not have been recognized before they were placed on treatments, or if they were and were then placed in an experimental treatment protocol, they may have a false beneficial response to whatever treatment was being given. Dyken was worried because this could have happened in some of his own studies Durant et al, 1982;Durant and Dyken, 1983] (Figs. 3 and 4).…”

Section: Clinical and Pathological Manifestationsmentioning

confidence: 99%

Neuroprogressive disease of post‐infectious origin: A review of a resurging subacute sclerosing panencephalitis (SSPE)

Dyken¹

2001

Ment. Retard. Dev. Disabil. Res. Rev.

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Subacute sclerosing panencephalitis (SSPE) is a progressive, essentially untreatable, disease of the nervous system. When first described in the 20th Century, it was characterized more for its neuropathological features than for its pathophysiology or cause. It was not until the 1960s that a clear relationship to the measles virus was established. It is now thought that this uncommon infectious encephalopathy is caused by a "slow," altered or persistent form of the wild measles virus which has harbored in the nervous system for years. Then a "breakout" occurs and the more lytic and virulent organisms produce the progressive and spreading inflammatory and destructive lesions which are confined to the nervous system. Epidemiological study of the disease confirms its relationship to measles. In the years since the development of national measles immunization programs, there has been a dramatic decline in the incidence of measles exanthem and until recently a corresponding decline in the incidence of SSPE. In recent years there has been a mild to moderate increase in cases of SSPE as reported to the USA/International SSPE Registry. As yet, there has not been a totally effective treatment. The purpose of this paper is to give an overall review on SSPE and its relationship to measles. This review will include a prospectus of its history, considerations as to its etiology, correlation of clinicopathological features, and thoughts on the past and present epidemiology and treatment.

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“…A registry form was used where we recorded the patients' age, sex, birthplace, ethnic background, history and age of natural measles infection, measles immunization status, and age at onset of SSPE symptoms. The stage and clinical course of the disease were assessed using the Brief Assessment Examination by Nester [20] and Neurological Disability Index scoring system by Durant [21]. The clinical, laboratory, and therapeutic data were also recorded.…”

Section: Subjectsmentioning

confidence: 99%