The influence of interferon-γ on cardiac and renal histopathological changes induced by carbamazepine

Bahmanpour, Soghra; Karimi, Fatemeh; Soleimani, Azam; Kamali, Midia; Namavar, Mohammad Reza

doi:10.4149/bll_2018_109

Cited by 1 publication

(4 citation statements)

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“…CBZ is in pregnancy category C according to the US Food and Drug Administration 21 . However, there are studies in the literature showing that the drug has teratogenic effects 14,22–30 . CBZ disrupts the central nervous system, 22 changes hematological parameters, 23 and causes testicular dysfunction and hormonal imbalance, 24 tubulointerstitial nephritis/necrosis, 25 and hepatic toxicity 26 in studies with pregnant rats.…”

Section: Introductionmentioning

confidence: 99%

“…It causes hypothyroidism in both mothers and fetuses. There are studies showing that it increases the risk of neural tube defects .5%–1%, causes a decrease in the birth weight of the offspring, 27–29 and causes growth retardation and neurodevelopmental toxicity 14,30 …”

Section: Introductionmentioning

confidence: 99%

“…21 However, there are studies in the literature showing that the drug has teratogenic effects. 14,[22][23][24][25][26][27][28][29][30] CBZ disrupts the central nervous system, 22 changes hematological parameters, 23 and causes testicular dysfunction and hormonal imbalance, 24 tubulointerstitial nephritis/necrosis, 25 and hepatic toxicity 26 in studies with pregnant rats. It causes hypothyroidism in both mothers and fetuses.…”

Section: Introductionmentioning

confidence: 99%

“…It causes hypothyroidism in both mothers and fetuses. There are studies showing that it increases the risk of neural tube defects .5%-1%, causes a decrease in the birth weight of the offspring, [27][28][29] and causes growth retardation and neurodevelopmental toxicity. 14,30 In recent years, it has been reported that antiepileptic drugs, including CBZ, cause a decrease in bone mineral density and an increase in fracture risk, and that 50% of the patients have bone anomalies such as osteopenia, osteoporosis, and osteomalacia.…”

Section: Introductionmentioning

confidence: 99%

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Bone development in offspring of pregnant rats treated with carbamazepine: Evaluation by three different methods

et al. 2022

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Objective This study was carried out to determine the effect of intrauterine carbamazepine (CBZ) exposure on fetal bone development during pregnancy. Methods In the study, 24 female Wistar pregnant rats were used. Rats were 20 weeks old. They had an average body weight of 150–200 g. Pregnant rats were randomly selected and divided (n = 6) into a control group, low‐dose CBZ (10 mg/kg/day) group, medium‐dose CBZ (25 mg/kg/day) group, and high‐dose CBZ (50 mg/kg/day) group. The ossification length (mm) and ossification area (mm2) of the long bones of the fetuses in the experimental and control groups were calculated. The densities of alkaline phosphatase (AP) and tartrate‐resistant acid phosphatase (TRAP) were analyzed. The ossification regions of the femurs of the fetuses were examined under a light microscope. Microstructural images of the femurs were evaluated with scanning electron microscope photographs. The densities of minerals involved in the ossification process were analyzed. Results According to the results of the study, all three doses of CBZ caused loss of ossification areas, and it was observed that this bone loss also increased statistically significantly depending on the dose increase (p < .05). Calcium concentration decreased in the CBZ groups. When the electron microscope images were examined, it was determined that the cartilage matrix of the CBZ groups was thinned. In the histological evaluation of the groups, narrowing of the primary bone collar and smaller bone spicules in the ossification region compared to the control group were noted due to the increase in dose in the CBZ groups. In immunohistochemical staining, it was observed that the TRAP and AP expression values of the femurs were the lowest in the CBZ groups. These decreases were also statistically significant when compared with the control group. Significance It was revealed with both microscopic and macroscopic findings that exposure to intrauterine CBZ negatively affected ossification and bone growth.

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