The Influence of Interleukin <i>17A</i> and <i>IL17F</i> Polymorphisms on Chronic Periodontitis Disease in Brazilian Patients

Zacarias, Joana Maira Valentini; Sippert, Emília; Tsuneto, Patrícia Yumeko; Visentainer, Jeane Eliete Laguila; Silva, Cléverson O.; Sell, Ana Maria

doi:10.1155/2015/147056

Cited by 37 publications

(28 citation statements)

References 71 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…IL17A AA genotype and A allele were associated with worse clinical and inflammatory periodontal parameters. IL17F polymorphisms were not associated to CP [78].…”

Section: Il17mentioning

confidence: 77%

Immunopathogenesis of Chronic Periodontitis

Sell¹,

Alencar²,

LaguilaVisentainer³

et al. 2017

Periodontitis - A Useful Reference

Self Cite

View full text Add to dashboard Cite

Periodontitis is a chronic inflammatory condition characterized by destruction of nonmineralized and mineralized connective tissues. The pathogenesis of periodontitis involves a complex interplay between periodontopathogens and the host immunity, greatly influenced by genetic and environmental factors. Failure in the inflammation resolving mechanism leads to establishment of a chronic inflammatory process, resulting in the progressive destruction of bone and soft tissue. The aim of this chapter is to summarize the role of innate and specific immune response involved in pathogenesis of periodontitis. Cells and inflammatory mediators, those participating in inflammatory process of the ligamentous supporting structure and in resorption of alveolar bone, will be presented.

show abstract

“…IL17A AA genotype and A allele were associated with worse clinical and inflammatory periodontal parameters. IL17F polymorphisms were not associated to CP [78].…”

Section: Il17mentioning

confidence: 77%

Immunopathogenesis of Chronic Periodontitis

Sell¹,

Alencar²,

LaguilaVisentainer³

et al. 2017

Periodontitis - A Useful Reference

Self Cite

View full text Add to dashboard Cite

show abstract

“…After reviewing the abstracts of the 33 articles, the irrelevant studies were excluded. Finally, five eligible studies were included in the meta‐analysis . Our case‐control results were added to the pooled data.…”

Section: Resultsmentioning

confidence: 99%

“…Finally, five eligible studies were included in the meta-analysis. [9][10][11]17,18 Our case-control results were added to the pooled data. The study-selection procedure is shown in Figure . Elementary data, including the name of the first author, publication…”

Section: Study Selection and Characteristicsmentioning

confidence: 99%

Association of A‐197G polymorphism in interleukin‐17 gene with chronic periodontitis: Evidence from six case‐control studies with a computational biology approach

Farmohammadi

Tavangar

Ehteram

et al. 2019

J of Invest & Clin Dent

View full text Add to dashboard Cite

Aim The aim of the present study was to evaluate the association of interleukin‐17 (IL‐17) A‐197G gene polymorphism with chronic periodontitis (CP) in a case‐control study, a meta‐analysis, and an in silico approach. Methods In the case‐control study, 122 cases with CP and 126 healthy controls were recruited; IL‐17 A‐197G genotyping was performed by polymerase chain reaction‐restriction fragment length polymorphism. In the meta‐analysis, comprehensive literature retrieval was performed on valid databases to identify relevant studies. Bioinformatics tools were employed to investigate the effects of A‐197G transition on the promoter region of IL‐17. Results Our case‐control study revealed a significant association between IL‐17 A‐197G transition and CP. The overall meta‐analysis revealed significant associations between the IL‐17 A‐197G polymorphism and CP risk in homozygote co‐dominant and recessive models. The stratified analysis also showed a statistically significant association between the mentioned transition and CP risk in the Caucasian population. The in silico analysis revealed that the A‐197G polymorphism could make changes in protein‐binding sites of the IL‐17 promoter region. Conclusions Our study supports that IL‐17 A‐197G transition could be a genetic risk factor for CP. However, further studies with a larger sample size among different ethnicities are required to obtain a more accurate conclusion.

show abstract

“…As the present study identified a low variability of IL-17F at position +7488C/T (similarly as other studies in other populations: http://www.snpedia.com/index.php/Rs763780 ), the TT genotype occurred in 93.7%, and no CC homozygote was detected, we investigated this polymorphism only in a subgroup of 190 subjects. Further, no associations of this polymorphism with aggressive periodontitis (AgP) or CP [ 31 – 33 ] have been previously found. In contrast, the IL-17A −197A/G SNP was analyzed in the whole set of our 523 subjects.…”

Section: Discussionmentioning

confidence: 99%

“…Despite the important role of IL-17 cytokine in T1DM and CP pathogenesis, no study has investigated IL-17 gene variability in T1DM patients so far and only a few studies have reported a relationship between polymorphisms in the IL-17 gene and periodontitis with contradictory results [ 29 – 33 ]. Therefore, in the present study, we aimed to investigate the association of IL-17A −197A/G (rs2275913) and IL-17F +7488C/T (His161Arg, rs763780) gene polymorphisms with T1DM and/or CP.…”

Section: Introductionmentioning

confidence: 99%

Interleukin-17AGene Variability in Patients with Type 1 Diabetes Mellitus and Chronic Periodontitis: Its Correlation with IL-17 Levels and the Occurrence of Periodontopathic Bacteria

Linhartová

Kaštovský

Lučanová

et al. 2016

Mediators of Inflammation

View full text Add to dashboard Cite

Interleukin-17 contributes to the pathogenesis of type 1 diabetes mellitus (T1DM) and chronic periodontitis (CP). We analyzed IL-17A −197A/G and IL-17F +7488C/T polymorphisms in T1DM and CP and determined their associations with IL-17 production and occurrence of periopathogens. Totally 154 controls, 125 T1DM, and 244 CP patients were genotyped using 5′ nuclease TaqMan® assays. Bacterial colonization was investigated by a DNA-microarray kit. Production of IL-17 after in vitro stimulation of mononuclear cells by mitogens and bacteria was examined by the Luminex system. Although no differences in the allele/genotype frequencies between patients with CP and T1DM + CP were found, the IL-17A −197 A allele increased the risk of T1DM (P < 0.05). Levels of HbA1c were significantly elevated in carriers of the A allele in T1DM patients (P < 0.05). Production of IL-17 by mononuclear cells of CP patients (unstimulated/stimulated by Porphyromonas gingivalis) was associated with IL-17A A allele (P < 0.05). IL-17A polymorphism increased the number of Tannerella forsythia and Treponema denticola in patients with CP and T1DM + CP, respectively (P < 0.05). IL-17A gene variability may influence control of T1DM and the “red complex” bacteria occurrence in patients with CP and T1DM + CP. Our findings demonstrated the functional relevance of the IL-17A polymorphism with higher IL-17 secretion in individuals with A allele.

show abstract

The Influence of Interleukin 17A and IL17F Polymorphisms on Chronic Periodontitis Disease in Brazilian Patients

Cited by 37 publications

References 71 publications

Immunopathogenesis of Chronic Periodontitis

Immunopathogenesis of Chronic Periodontitis

Association of A‐197G polymorphism in interleukin‐17 gene with chronic periodontitis: Evidence from six case‐control studies with a computational biology approach

Interleukin-17AGene Variability in Patients with Type 1 Diabetes Mellitus and Chronic Periodontitis: Its Correlation with IL-17 Levels and the Occurrence of Periodontopathic Bacteria

Contact Info

Product

Resources

About