The Influence of Intermittent Hypoxemia on Platelet Activation in Obese Patients with Obstructive Sleep Apnea

Rahangdale, Shilpa; Yeh, Susie Yim; Novack, Victor; Stevenson, Karen; Barnard, Marc R.; Furman, Mark I.; Frelinger, Andrew L.; Michelson, Alan D.; Malhotra, Atul

doi:10.5664/jcsm.28105

Cited by 54 publications

(39 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…36,37 Second, hypoxia is reported to affect key components in the pathogenesis of thrombus formation. Hypoxia increases platelet reactivity 38,39 and, though controversial, hypoxia has been shown to increase coagulation activation in some 40 but not all studies. 41 Third, systemic hypoxia has been shown to accelerate thromboembolic events in mice through induction of the nucleotide-binding domain, leucine-rich-containing family, pyrin domain-containing 3 inflammasome complex.…”

Section: Discussionmentioning

confidence: 99%

Impact of respiratory symptoms and oxygen saturation on the risk of incident venous thromboembolism—the Tromsø study

Børvik

Evensen

Morelli

et al. 2020

Research and Practice in Thrombosis and Haemostasis

View full text Add to dashboard Cite

Background Chronic obstructive pulmonary disease (COPD) is associated with risk of venous thromboembolism (VTE). It remains unknown whether individual respiratory symptoms and lowered oxygen saturation (SpO2), individually and in combination with COPD, affect the risk of VTE. Objectives To investigate whether measures of respiratory impairments including respiratory symptoms and SpO2, individually and combined with COPD, were associated with an increased risk of VTE. Methods Spirometry, SpO2, and self‐reported respiratory symptoms were collected in 8686 participants from the fifth (2001‐2002) and sixth (2007‐2008) surveys of the Tromsø Study. Incident VTE events were registered from the date of inclusion to December 31, 2016. Cox regression models with exposures and confounders as time‐varying covariates (for repeated measurements) were used to estimate hazard ratios (HRs) with 95% confidence intervals (CIs) for VTE. Results During a median follow‐up of 9.1 years, 330 participants developed incident VTE. Subjects with SpO2 ≤ 96% (lowest 20th percentile) had a 1.5‐fold higher risk of VTE (adjusted HR, 1.48; 95% CI, 1.13‐1.93) compared with those with SpO2 ≥ 98%. Severe respiratory symptoms (dyspnea, cough, and phlegm) were associated with a 1.4‐ to 2.0‐fold higher risk of VTE compared with no such symptoms. COPD, combined with respiratory symptoms or lowered SpO2, had an additive effect on the VTE risk. Conclusions Lowered SpO2 and severe respiratory symptoms were associated with increased VTE risk. COPD combined with respiratory impairments had an additive effect on VTE risk, and may suggest particular attention on VTE preventive strategies in COPD patients with respiratory impairments.

show abstract

Section: Discussionmentioning

confidence: 99%

Impact of respiratory symptoms and oxygen saturation on the risk of incident venous thromboembolism—the Tromsø study

Børvik

Evensen

Morelli

et al. 2020

Research and Practice in Thrombosis and Haemostasis

View full text Add to dashboard Cite

show abstract

“…OSAS progresses with inflammation and airway remodeling and is associated with systemic inflammation [2]. Systemic inflammation is also strongly related with various metabolic and cardiovascular diseases such as peripheral vascular disease, coronary artery disease, hypertension, heart failure, cardiac arrhythmias, and diabetes mellitus [2,3]. Red cell distribution width (RDW), platelet activation and inflammation are connected with OSAS pathogenesis.…”

Section: Introductionmentioning

confidence: 99%

“…There are studies indicating that erythrocyte distribution width and platelet activation increase in cardiovascular events. Mean platelet volume (MPV) and Platelet distribution width (PDW) are indicators of platelet activation [3,4].…”

Section: Introductionmentioning

confidence: 99%

Comparison of erythrocyte distribution width, mean platelet volume and platelet distribution width in patients with obstructive sleep apnea syndrome

Çelikhisar¹,

Ilkhan²

2019

Journal of Surgery and Medicine

View full text Add to dashboard Cite

This is an open access article distributed under the terms of the CreativeCommons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND 4.0) where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal. AbstractAim: Reliable markers are needed to evaluate the response of chronic inflammation in obstructive sleep apnea syndrome (OSAS) to positive airway pressure (PAP) treatment. In this study, we aimed to investigate the long-term effects of PAP treatment on hemogram parameters and its relationship with inflammation and severity of disease in OSAS patients. Methods: Based on polysomnography (PSG) results, 61 (35.1%) participants and 113 OSAS patients (64.9%) were included in the control and study groups, respectively. Among these patients, 31.6% had moderate and 33.3% had severe OSAS. MPV, PDW, RDW, hemoglobin, hemotocrit, platelet values were evaluated and compared between the groups at six and twelve-month intervals in this prospective cohort study. Results: All participants (n=174) were males aged between 33-62 years. Hemoglobin, hematocrit and MPV values of the study group were significantly higher at the baseline (P=0.008, P=0.007, P=0.004, respectively) and had decreased significantly by the 6 th and 12 th months in both groups P=0.004, P=0.003, P=0.004, respectively). Conclusion: All participants were chosen from males to exclude hormonal effects on hemogram parameters, which also turned out to be a limitation of this study. Our study showed a correlation between MPV, RDW, PDW, hemoglobin and hematocrit values and OSAS severity. MPV, RDW, hemoglobin, hematocrit and platelet may be considered inexpensive biomarkers easily obtained from blood tests which make it useful in determining the severity of OSAS and prioritizing patients for PAP therapy. Öz Amaç: Obstrüktif uyku apne sendromunda (OUAS) intermitant hipoksiye bağlı gelişen kronik inflamasyonun PAP tedavisine yanıtını değerlendirmede kullanılacak güvenilir belirteçlere ihtiyaç vardır. Bu çalışmada, pozitif havayolu basıncı tedavisinin uzun dönem sonuçlarının hemogram parametreleri üzerine etkisini ve OUAS'lı hastalarda inflamasyon ve hastalığın ciddiyeti ile ilişkisini araştırmayı amaçladık. Yöntemler: Çalışma prospektif kohort tipi çalışma olarak planlandı. Polisomnografi (PSG) sonuçlarına göre OUAS saptanmayan 61 katılımcı (%35.1) kontrol grubu olarak alındı. OUAS saptanan 113 hasta (%64,9) çalışma grubu olarak alındı. Çalışma grubunun (%31,6)'sı orta OUAS, 58'i (%33,3) şiddetli OUAS idi. Hastaların MPV, PDW, RDW, hemoglobin, hemotokrit, trombosit değerleri değerlendirildi ve altı ve on iki ay arayla karşılaştırıldı. Bulgular: Yaşları 33 ile 62 arasında değişen, toplam 174 hasta çalışmaya alındı. Başlangıçta hemoglobin, hematokrit ve MPV değerleri çalışma grubunda kontrol grubuna göre anlamlı derecede yüksek (sırasıyla P=0,008, P=0,007, P=0,004), her iki grupta da 6 ve 12 aydaki düşüşler istatistiksel olarak anlamlıy...

show abstract

“…Az sayıdaki hastada ventriküler taşikardiler veya ani ölümler görülebilir (7,(9)(10)(11). Trombosit aktivasyonu ve enflamasyon, OUAS patogeneziyle ilişkili mekanizmalardır (12,13). Trombosit aktivasyonu sonucu, trombozda artış ve buna bağlı olarak kardiyovasküler olaylarda artış saptanır (14).…”

Section: Introductionunclassified

Redcell Distribution Width, Mean Platelet Volume, Platelet Distribution Width Parameters and Disease Severity Relationship in Patients with Obstructive Sleep Apnea Syndrome

Demir¹

2016

jtsm

View full text Add to dashboard Cite

Ge liş Ta ri hi/Re cei ved: 27.04.2016 Ka bul Ta ri hi/Ac cep ted: 26.09.2016 © Tür k Uyku Tıbbi Der gi si, Ga le nos Ya yı ne vi ta ra fın dan ba sıl mış tır. / © Journal of Turkish Sleep Me di ci ne, Pub lis hed by Ga le nos Pub lis hing. Bu makale "Creative Commons Alıntı-Gayriticari-Türetilemez 4.0 Uluslararası Lisansı (CC BY-NC 4.0)" ile lisanslanmıştır. / This article is distributed under the terms of the "Creative Commons Attribution NonCommercial 4.0 International Licence (CC BY-NC 4.0)". Objective: To evaluate the relationship between redcell distrubution width (RDW), platelet distribution width (PDW), mean platelet volume (MPV) parameters and the disease severity in Obstructive sleep apnea syndrome (OSAS) patients; to benefit from the biomarkers to take early measures on disease treatment, follow-up and complications (as thromboembolic events and cardiovascular diseases). Materials and Methods: Our study is a retrospective and a cross-sectional study and we planned to asses polysomnography (PSG) records of the patients. Patients who were diagnosed with OSAS by PSG were grouped as 108 mild patients with [Respiratory Disturbance Index (RDI): 5-14.9]; 69 moderate patients (RDI: 15-30); 66 severe patients (RDI>30) and 117 patients were control group (RDI<5). The age range was between 18 and 78. Inclusion criterions were routine blood count, RDW, MPV and PDW. Results: Three hundred and sixty patients were enrolled in the study. 74.2% of them were male; mean age was 46.5. The average patient O 2 saturation was 93.2. When moderate OSAS group was compared with the control group, hematocrit (Htc) (p=0.004) and hemoglobin (Hb) (p=0.002) were found to be significantly increased. When severe OSAS group was compared with the control group, MPV (p=0.017) was decreased significantly, Htc (p=0.006) and Hb (p=0.02) were found to be significantly increased. Conclusion: In our study, when the other groups and the control group were compared, we observed significantly increased Hb and Htc values in moderate and severe OSAS groups, however some other studies gives an increase in MPV we observed a decrease in severe group. Having few number of patients in moderate and severe OSAS groups may have led to such results. Therefore, more extensive and prospective studies are needed.

show abstract

The Influence of Intermittent Hypoxemia on Platelet Activation in Obese Patients with Obstructive Sleep Apnea

Cited by 54 publications

References 39 publications

Impact of respiratory symptoms and oxygen saturation on the risk of incident venous thromboembolism—the Tromsø study

Impact of respiratory symptoms and oxygen saturation on the risk of incident venous thromboembolism—the Tromsø study

Comparison of erythrocyte distribution width, mean platelet volume and platelet distribution width in patients with obstructive sleep apnea syndrome

Redcell Distribution Width, Mean Platelet Volume, Platelet Distribution Width Parameters and Disease Severity Relationship in Patients with Obstructive Sleep Apnea Syndrome

Contact Info

Product

Resources

About