The Influence of Levothyroxine on Body Composition and Physical
                    Performance in Subclinical Hypothyroidism

Hanke, Lars; Poeten, Pascal; Spanke, Leroy; Britz, Stephanie; Diel, Patrick

doi:10.1055/a-1968-0106

Cited by 3 publications

(1 citation statement)

References 26 publications

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“…Our data also support the findings from other studies, that treatment with levothyroxine does not decrease weight in individuals with obesity and no thyroid disease (28)(29)(30)(31). This could be partially explained by our findings, with higher FT4 levels predisposing weight gainMore complicated is the situation in individuals with obesity and concomitant Hashimoto thyroiditis.…”

Section: Clinical Application Of the Resultssupporting

confidence: 92%

Thyroid hormone levels and BMI-SDS changes in adolescents with obesity

Staníková,

Krajčovičová,

Lobotková

et al. 2023

Front. Endocrinol.

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BackgroundThyroid hormones play an important role in energy metabolism and weight control, explained mostly by inducing thermogenesis and increasing basal metabolic rate. It has recently been shown that FT4 levels are associated with food preferences, which might also play a role in modulating body weight. The aim of this longitudinal follow-up study was to analyze the relationship of thyroid hormones levels (FT4, TSH) at baseline with weight/BMI-SDS changes in children and adolescents with obesity.MethodsThree hundred seventy-seven children and adolescents have been enrolled to this study and followed up without a systematic intervention program for 5.59 ± 1.85months. Children and adolescents were divided into three subgroups: 1) 144 adolescents with obesity (15-19 years), 2) 213 children with obesity (10-14.9 years), and 3) 20 lean adolescents (15-19 years). Thyroid hormones were measured at the baseline, and anthropometry was performed at the baseline and during the follow-up. For further analyses, participants were divided according to the BMI-SDS change into two groups: 1. with BMI-SDS decrease, and 2. with BMI-SDS increase.ResultsAdolescents with obesity from the BMI-SDS decrease group had significantly lower baseline serum levels of TSH compared to the BMI-SDS increase group (2.4 ± 1.0 vs. 3.2 ± 2.0mIU/l; p=0.005). Similar difference was found for FT4 levels (14.7 ± 2.2 in the BMI-SDS decrease group vs. 15.5 ± 2.7pmol/l in the BMI-SDS increase group, p=0.048). Moreover, the BMI-SDS decrease was present in significantly higher percentage of adolescents with obesity with lower than median TSH level compared to those with higher than median TSH level at baseline (61.1% vs 38.6%, p=0.011). Likewise, the BMI-SDS decrease was present in significantly higher percentage of adolescent females with obesity and lower than median FT4 compared to those with higher than median FT4 level at baseline (70.6% vs. 23.5%, p<0.001). No associations of baseline thyroid hormones with the BMI-SDS change were observed in children with obesity or lean adolescents.ConclusionAdolescents with obesity and increased BMI-SDS during the follow-up had significantly higher baseline levels of both TSH and FT4 compared to BMI-SDS decrease group. These results support the previous findings that higher FT4 in individuals with obesity may influence weight gain.

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Section: Clinical Application Of the Resultssupporting

confidence: 92%

Thyroid hormone levels and BMI-SDS changes in adolescents with obesity

Staníková,

Krajčovičová,

Lobotková

et al. 2023

Front. Endocrinol.

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Associations between thyroid hormones and appendicular skeletal muscle index, and hand grip strength in people with diabetes: The KAMOGAWA-A study

Hata,

Okada,

Minamida

et al. 2024

Diabetes Research and Clinical Practice

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Features of the natural course of subclinical hypothyroidism in young athletes

Stolyarova,

Okorokov,

Zyabkin

et al. 2023

jour

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Objective: to assess the natural course of subclinical hypothyroidism in young athletes.Methods: In the prospective single-center uncontrolled study, data from 3,062 outpatient records of young athletes (members of the Russian national team) of both sexes (middle age — 15 [14; 16] years) and underwent medical examination in the period from January 2021 to September 2022 were studied. All athletes were divided into 2 groups according to the presence of subclinical hypothyroidism (an increase in the level of thyroid-stimulating hormone from 5 to 10 mUn/l with a normal level of T4 free). During a dynamic follow-up (1 year), athletes with subclinical hypothyroidism underwent a repeated study of the concentration of thyroid-stimulating hormone, free thyroxine and antibodies to thyroperoxidase.Results: Signs of subclinical hyperthyroidism were found in 58 young athletes (30 boys (51.7 %) and 28 (48.3 %) girls). During dynamic observation with continued habitual physical activity, spontaneous normalization of the level of thyroid-stimulating hormone was observed in 74 % of young athletes. At the same time, normalization of thyroid-stimulating hormone in girls was observed less often compared to boys (p = 0,272). In no case did clinically pronounced hypothyroidism develop.Conclusion: The majority of young male and female athletes with subclinical hypothyroidism have spontaneous normalization of hormonal profile against the background of persistent physical and psycho-emotional stress. The data obtained make it possible, subject to the possibility of dynamic observation, to recommend doctors working with young elite athletes not to prescribe hormonal replacement therapy and not to modify the usual lifestyle.

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The Influence of Levothyroxine on Body Composition and Physical Performance in Subclinical Hypothyroidism

Cited by 3 publications

References 26 publications

Thyroid hormone levels and BMI-SDS changes in adolescents with obesity

Thyroid hormone levels and BMI-SDS changes in adolescents with obesity

Associations between thyroid hormones and appendicular skeletal muscle index, and hand grip strength in people with diabetes: The KAMOGAWA-A study

Features of the natural course of subclinical hypothyroidism in young athletes

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