The influence of lipid-containing plaque composition assessed by near-infrared spectroscopy on coronary lesion remodelling

Ota, Hiroyoshi; Magalhães, Marco A.; Torguson, Rebecca; Negi, Smita; Kollmer, Max R.; Spad, Mia-Ashley; Gai, Jiaxiang; Satler, Lowell F.; Suddath, William O.; Pichard, Augusto D.; Waksman, Ron

doi:10.1093/ehjci/jev221

Cited by 16 publications

(11 citation statements)

References 26 publications

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“…The degradation of the extracellular matrix is not only toward to the luminal side of the plaque but also toward the abluminal layer, thus weakening the vessel wall [ 37 ]. Moreover, a higher macrophage count and lipid content has shown significant associations with positive remodeling in human coronary artery with plaques [ 38 ][ 39 ].…”

Section: Discussionmentioning

confidence: 99%

Accelerated atherogenesis in completely ligated common carotid artery of apolipoprotein E-deficient mice

et al. 2017

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Complete ligation of the common carotid artery near its bifurcation induces neointimal formation due to smooth muscle cell proliferation in normolipidemic wild-type mice, but it was unknown what would happen to hyperlipidemic apolipoprotein E-deficient (Apoe-/-) mice. Examination of these mice revealed rapid development of atherosclerotic lesions in completely ligated carotid arteries within 4 weeks. Mice were fed a Western diet, starting 1 week before ligation, or a chow diet. Foam cell lesions formed as early as 1 week after ligation in mice fed the Western diet and 2 weeks in mice fed the chow diet. Fibrous lesions comprised of foam cells and smooth muscle cells and more advance lesions containing neovessels occurred at 2 and 4 weeks after ligation, respectively, in the Western diet group. Lesions were larger and more advanced in the Western diet group than the chow group. Neutrophil infiltration was observed in growing intimal lesions in both diet groups, while CD8+ T cells were found in lesions of chow-fed mice. This study demonstrates that Apoe-/- mice develop the entire spectrum of atherosclerosis in ligated carotid arteries in an accelerated manner and this model could be a valuable tool for investigating the development and therapy of atherosclerosis.

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Section: Discussionmentioning

confidence: 99%

Accelerated atherogenesis in completely ligated common carotid artery of apolipoprotein E-deficient mice

et al. 2017

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“…Non-stenotic carotid atheroma has been implicated as a cause of previously classified “cryptogenic” stroke, with non-stenotic plaques demonstrating high-risk morphological features (hemorrhage, thrombus, or fibrous cap rupture) having a higher association with ischemic stroke than those without high-risk features [ 8 , 9 ]. Furthermore, intravascular imaging of coronary artery atherosclerosis has demonstrated that a significant atheroma burden with a high risk of subsequent cardiac events may be present in the absence of luminal stenosis due to outward artery remodeling [ 10 – 12 ]. Similar findings of high-risk plaques in the presence of non-obstructive lesions have been shown in humans with imaging of coronary remodeling using CT [ 13 , 14 ].…”

Section: Introductionmentioning

confidence: 99%

PET Imaging of Atherosclerotic Disease: Advancing Plaque Assessment from Anatomy to Pathophysiology

Evans

Tarkin

Chowdhury

et al. 2016

Curr Atheroscler Rep

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Atherosclerosis is a leading cause of morbidity and mortality. It is now widely recognized that the disease is more than simply a flow-limiting process and that the atheromatous plaque represents a nidus for inflammation with a consequent risk of plaque rupture and atherothrombosis, leading to myocardial infarction or stroke. However, widely used conventional clinical imaging techniques remain anatomically focused, assessing only the degree of arterial stenosis caused by plaques. Positron emission tomography (PET) has allowed the metabolic processes within the plaque to be detected and quantified directly. The increasing armory of radiotracers has facilitated the imaging of distinct metabolic aspects of atherogenesis and plaque destabilization, including macrophage-mediated inflammatory change, hypoxia, and microcalcification. This imaging modality has not only furthered our understanding of the disease process in vivo with new insights into mechanisms but has also been utilized as a non-invasive endpoint measure in the development of novel treatments for atherosclerotic disease. This review provides grounding in the principles of PET imaging of atherosclerosis, the radioligands in use and in development, its research and clinical applications, and future developments for the field.

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“…Multivariable analysis also demonstrated maximum plaque burden as a signi cant predictor for LCBI and maxLCBI 4mm in the present study. Plaque burden was reported to be positively correlated with LCBI in previous studies [19]. Therefore, less plaque burden in the MB segment might cause lower LCBI, despite possibly high WSS in the MB segment.…”

Section: Discussionmentioning

confidence: 82%

Influence of Myocardial Bridge On Atherosclerotic Plaque Distribution and Characteristics Evaluated By Near-Infrared Spectroscopy Intravascular Ultrasound

Saito

Kitahara

Mastuoka

et al. 2021

Preprint

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Purpose This study aims to clarify whether myocardial bridge (MB) could influence atherosclerotic plaque characteristics assessed by using near-infrared spectroscopy-intravascular ultrasound (NIRS-IVUS) imaging. Methods One hundred and sixteen patients who underwent percutaneous coronary intervention (PCI) using NIRS-IVUS imaging were included. MB was defined as an echo-lucent band surrounding left anterior descending artery (LAD). In MB patients, LAD was divided into 3 segments: proximal, MB, and distal segments. In non-MB patients, corresponding 3 segments were defined based on the average length of the above segments. Segmental maximum plaque burden and lipid content derived from NIRS-IVUS imaging in the section of maximum plaque burden were evaluated in each segment. Lipid content of atherosclerotic plaque was evaluated as lipid core burden index (LCBI) and maxLCBI4mm. LCBI is the fraction of pixels indicating lipid within a region multiplied by 1000, and the maximum LCBI in any 4-mm region was defined as maxLCBI4mm. Results MB was identified in 42 patients. MB was not associated with maximum plaque burden in proximal segment. LCBI and maxLCBI4mm were significantly lower in patients with MB than those without in proximal segment. Multivariable analysis demonstrated both MB and maximum plaque burden in proximal segment to be independent predictors of LCBI in proximal segment. Conclusion Lipid content of atherosclerotic plaque assessed by NIRS-IVUS imaging was significantly smaller in patients with MB than those without. MB could be considered as a predictor of lipid content of atherosclerotic plaque when assessed by NIRS-IVUS imaging.

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The influence of lipid-containing plaque composition assessed by near-infrared spectroscopy on coronary lesion remodelling

Abstract: In vivo coronary lesion remodelling is positively correlated with lipid plaque content assessed by NIRS rather than simply PB. Thus, the use of NIRS can potentially aid in further stratifying vulnerable lesions.

Cited by 16 publications

References 26 publications

Accelerated atherogenesis in completely ligated common carotid artery of apolipoprotein E-deficient mice

Accelerated atherogenesis in completely ligated common carotid artery of apolipoprotein E-deficient mice

PET Imaging of Atherosclerotic Disease: Advancing Plaque Assessment from Anatomy to Pathophysiology

Influence of Myocardial Bridge On Atherosclerotic Plaque Distribution and Characteristics Evaluated By Near-Infrared Spectroscopy Intravascular Ultrasound

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