The influence of low level laser irradiation on vascular reactivity

Mackiewicz−Milewska, Magdalena; Grześk, Elżbieta; Kroszczyński, Andrzej C.; Cisowska-Adamiak, Małgorzata; Mackiewicz‐Nartowicz, Hanna; Baran, L; Szymkuć-Bukowska, Iwona; Wiciński, Michał; Hagner, Wojciech; Grześk, Grzegorz

doi:10.1016/j.advms.2017.06.002

Cited by 4 publications

(8 citation statements)

References 21 publications

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“…In the experiments performed in the present study, removal of the vascular endothelium prevented the inhibitory effect of laser irradiation on vessel walls stimulated by G-protein with mastoparan-7; consequently, we concluded that laser vasodilation in mastoparan-7-induced arteries may be an endothelium-dependent process. Similar effects were observed for endothelin-1 and phenylephrine stimulation of entothelin-1 and α 1 -adrenoceptors, respectively (17).…”

Section: Discussionsupporting

confidence: 72%

“…The present study investigated the possibility of the induction of photorelaxation in laser-pretreated arteries. Results from our previous studies confirmed the occurrence of photorelaxation in arteries stimulated with receptor agonists (17,18,29,30). Constriction of vascular smooth muscle cells in the presence of mastoparan-7 was demonstrated by Kanagy and Webb (29), and Birnbaumer (30) described experiments on spiral cutting fragments of the common carotid artery.…”

Section: Discussionsupporting

confidence: 71%

“…Previous studies performed on vessels suggested that laser photorelaxation in vessels stimulated pharmacologically is partially endothelium-dependent process (17,18), therefore degradation of the vascular endothelium may able to eliminate the inhibitory effect of laser irradiation on vessels reactivity. In the experiments performed in the present study, removal of the vascular endothelium prevented the inhibitory effect of laser irradiation on vessel walls stimulated by G-protein with mastoparan-7; consequently, we concluded that laser vasodilation in mastoparan-7-induced arteries may be an endothelium-dependent process.…”

Section: Discussionmentioning

confidence: 99%

“…The laser was applied in increasing doses of 10 mW ('L1'; E=1.8 J), 30 mW ('L2'; E=5.5 J), 110 mW ('L3'; E=19.8 J). Time of exposition was 3 min for each irradiation (17). In experiments performed on endothelium-denudated arteries, the endothelium was removed with the compressed air (temperature=37˚C, pressure = 1.0-1.1 atm).…”

Section: Methodsmentioning

confidence: 99%

“…Two studies (11,13) have demonstrated that LLLI may cause photorelaxation of blood vessels, including coronary arteries, and may prevent their restenosis following percutaneous transluminal coronary angioplasty (11,16). A number of experimental studies analyzed the effect of LLLI on vascular smooth muscle cells following pretreatment with α-adrenoceptors agonists (adrenalin and phenylephrine) and peptides, including vasopressin or endothelin-1 (17,18). To the best of our knowledge, the effect of non-receptor stimulation has not been analyzed previously.…”

Section: Introductionmentioning

confidence: 99%

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Modulatory effect of laser irradiation on mastoparan‑7‑induced contraction

et al. 2019

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Mastoparan-7 activates guanine nucleotide-binding proteins (G-proteins) and stimulates both apoptosis and increases in cytoplasmic calcium concentration and may induce smooth muscle contraction. The primary aim of the present study was to evaluate the modulatory effect of laser stimulation on vascular smooth muscle contraction induced by direct stimulation of G-protein with mastoparan-7. Experiments were performed on isolated and perfused tail arteries of Wistar rats. Contraction force in the model was measured by increased levels of perfusion pressure with a constant flow. Irradiation treatment was applied directly to the blood vessels. The laser was applied in increasing doses of 10 mW (E=1.8 J), 30 mW (E=5.5 J) and 110 mW (E=19.8 J). Time of exposure was 3 min for each irradiation. In the laser-stimulated arteries, a significant and dose-dependent decrease was observed. The half maximal effective concentration values were 4.43±2.2x10-8 , 2.4±0.56x10-7 , 3.2±0.72x10-7 and 7.7±0.3x10-7 M/l in the control and 10, 30 and 110 mW laser irradiation groups, respectively. Significant (P<0.001) changes were identified for all laser treatment groups in comparison with the control. When analyzing the function of calcium ion (Ca 2+) stores was analyzed, a significant inhibition of influx from both intra-and extracellular Ca 2+ stores was observed. The results from the present study suggested that contraction induced by direct activation of G-protein with mastoparan-7 may by effectively inhibited by laser radiation, and that the effect was associated with an inhibition of Ca 2+ influx from both intracellular and extracellular Ca 2+ stores.

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Section: Discussionsupporting

confidence: 72%

Section: Discussionsupporting

confidence: 71%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Modulatory effect of laser irradiation on mastoparan‑7‑induced contraction

et al. 2019

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Low-level laser therapy combined with scleral graft transplantation in the treatment of contracted socket: a clinical study

Huang,

Fang,

Lai

et al. 2023

BMC Ophthalmol

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Objective To analyse the efficacy of the therapeutic use of low-level laser therapy (LLLT) on the tissue repair process of allogeneic scleral grafts in patients with contracted sockets by analysing the speed of graft vascularisation and fornice depth of contraction percentage. Methods A retrospective chart review was performed from April 2015 to April 2021 including 39patients with socket contraction. Allogeneic scleral grafts were used to repair the sockets in all patients. They were randomly enrolled into two groups. The laser group included 18 patients treated with LLLT after the surgery, whereas the control group included 21 patients without LLLT after the surgery who healed naturally. The LLLT equipment used in the research had a wavelength of 650 nm, 10 mW power, and 3.8 J/cm2 dosimetry, and the procedure was performed once daily for 5 min over 7 days, beginning 1 week postoperatively. All patients were followed up over 6 months to examine the changes in the size of the area of the non-vascularised graft and upper and inferior fornice depth. Results The laser group presented a significantly increased speed of conjunctival vascularisation compared with the control group (P = 0.003). The fornice depth of contraction percentage was more apparent in the control group than that in the laser group (P = 0.000). Conclusion LLLT accelerates conjunctival vascularisation, stimulates conjunctival incision healing within a short period, shortens the tissue repair process, reduces the local inflammatory response, and causes no significant shrinkage of the conjunctival sac.

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The Anti-Inflammatory and Anti-Oxidant Mechanisms of the Keap1/Nrf2/ARE Signaling Pathway in Chronic Diseases

Tu¹,

Wang²,

Li³

et al. 2019

Aging and disease

475

280

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Oxidative stress is defined as an imbalance between production of free radicals and reactive metabolites or [reactive oxygen species (ROS)] and their elimination by through protective mechanisms, including (antioxidants). This Such imbalance leads to damage of cells and important biomolecules and cells, with hence posing a potential adverse impact on the whole organism. At the center of the day-to-day biological response to oxidative stress is the Kelch-like ECH-associated protein 1 (Keap1) - nuclear factor erythroid 2-related factor 2 (Nrf2)- antioxidant response elements (ARE) pathway, which regulates the transcription of many several antioxidant genes that preserve cellular homeostasis and detoxification genes that process and eliminate carcinogens and toxins before they can cause damage. The redox-sensitive signaling system Keap1/Nrf2/ARE plays a key role in the maintenance of cellular homeostasis under stress, inflammatory, carcinogenic, and pro-apoptotic conditions, which allows us to consider it as a pharmacological target. Herein, we review and discuss the recent advancements in the regulation of the Keap1/Nrf2/ARE system, and its role under physiological and pathophysiological conditions, e.g. such as in exercise, diabetes, cardiovascular diseases, cancer, neurodegenerative disorders, stroke, liver and kidney system, etc. and such.

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The influence of low level laser irradiation on vascular reactivity

Cited by 4 publications

References 21 publications

Modulatory effect of laser irradiation on mastoparan‑7‑induced contraction

Modulatory effect of laser irradiation on mastoparan‑7‑induced contraction

Low-level laser therapy combined with scleral graft transplantation in the treatment of contracted socket: a clinical study

The Anti-Inflammatory and Anti-Oxidant Mechanisms of the Keap1/Nrf2/ARE Signaling Pathway in Chronic Diseases

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