The influence of maternal respiratory allergy on obstetrics and perinatal outcomes: A nested case–control study

Bartha, Irene; Fuente, Miguel De La; Calle, María de la; Boado, Elena Martín; Martínez-Sánchez, Nuria; Bartha, José Luis

doi:10.1002/ijgo.14562

Cited by 1 publication

(3 citation statements)

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“…This may be due to reduce statistical power for these secondary outcomes. Furthermore, in another study recently published by our group with a higher number of cases, we found significant associations 29 . The rates of PTD and LBW in the present study were similar to other published data, which established the prevalence of both perinatal outcomes to range from 5% to 13% and from 8% to 16%, respectively 3,6,12–14,18 .…”

Section: Discussionsupporting

confidence: 92%

“…Furthermore, in another study recently published by our group with a higher number of cases, we found significant associations. 29 The rates of PTD and LBW in the present study were similar to other published data, which established the prevalence of both perinatal outcomes to range from 5% to 13% and from 8% to 16%, respectively. 3 , 6 , 12 , 13 , 14 , 18 However, due to the sample size in the allergic group, no meaningful conclusions could be drawn regarding PTD and LBW.…”

Section: Discussionsupporting

confidence: 91%

“…Maternal median age was 34 years in both groups, and patients were mainly in the age range [25][26][27][28][29][30][31][32][33][34][35] population, respectively, and an allergic etiology was diagnosed in 43 (87.8%) and 18 (18.6%) of these patients correspondingly. Pollen was the main aeroallergen identified in all of the patients (43; 100%), followed by house dust mite (30; 69.8%).…”

Section: Re Sultsmentioning

confidence: 99%

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The influence of air pollution on gestational age at delivery and birthweight in patients with or without respiratory allergy: A nested case–control study

Bartha,

De La Fuente,

Martinez‐Sanchez

et al. 2023

Acta Obstet Gynecol Scand

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IntroductionAir pollution is a current major health issue. The burden of airborne pollutants and aeroallergen levels varies throughout the year, as well as their interaction and consequences. Prenatal exposure during pregnancy has been associated with adverse perinatal outcomes. The aim of this study was to evaluate the impact of air pollutants on perinatal outcomes in patients with or without respiratory allergy.Material and methodsNested case–control retrospective study on 3006 pregnant women. Correlations between concentrations of common pollutants in each trimester of pregnancy and on average during the whole pregnancy and both gestational age at delivery and birthweight were studied. Pearson's correlation coefficient and binary logistic regression were used.ResultsIn general, pollutants correlated more strongly with birthweight than with gestational age at delivery. Nine‐month NO2, SO2, CO, and benzene, and second‐trimester CO negatively correlated with birthweight, whereas only first‐trimester NO2 showed a very mild correlation with gestational age at delivery. Negative correlations between pollutants and birthweight were much stronger in the respiratory allergy group (n = 43; 1.4%) than in the non‐allergic group. After adjustments, the most significant predictive pollutant of birthweight was SO2 in both groups. The best predictive model was much stronger in the allergic group for third‐trimester SO2 (R2 = 0.12, p = 0.02) than in the non‐allergic group for total SO2 (R2 = 0.002, p = 0.02). For each unit that SO2 increased, birthweight reduced by 3.22% vs. 1.28% in each group, respectively.ConclusionsAir pollutant concentrations, especially SO2, negatively influenced birthweight. The impact of this association was much stronger and more relevant in the group of women with respiratory allergies.

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Section: Discussionsupporting

confidence: 92%