The influence of maternal smoking on maternal and newborn oxidant and antioxidant status

Orhon, Filiz Şimşek; Ulukol, Betül; Kâhya, Didem; Cengiz, Bora; Başkan, Semih; Tezcan, Sevgi

doi:10.1007/s00431-008-0873-0

Cited by 60 publications

(54 citation statements)

References 26 publications

(40 reference statements)

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“…Smo king in cre a ses vi ta min E con sump ti on which ac cor dingly increases pe ro xi de pro duc ti on ex ces si vely, and con se qu ently, pros tacy clin ca u ses pla cen ta to be thin down pre ven ting the fe tus to be no u ris hed ade qu a tely. [21][22][23] In our study, when the fin dings of smo king mot hers we re com pa red to ne ver smo king mot hers, the per cen ta ge of placental abruption was higher in the smokers. Ho we ver, this re sult was not sta tis ti cally sig ni fi cant.…”

Section: Referencesmentioning

confidence: 51%

Evaluation of Smoking Among Pregnant Women in a Central Anatolian City of Turkey: Comparison with Other Countries

Marakoğlu¹,

Erdem²

2011

Turkiye Klinikleri J Med Sci

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A AB BS S T TR RA AC CT T O Ob b j je ec c t ti i v ve e: : The aim of this study is to eva lu a te the rate of smo king and pe ri na tal outco mes of ma ter nal smo king du ring preg nancy in a hos pi tal-ba sed study. M Ma a t te e r ri i a al l a an nd d M Me et t h ho od ds s: : All ca ses rec ru i ted to the study we re as ked to res pond to a se ri es of qu es ti ons in a fa ce-to-fa ce in ter view on the first day af ter de li very. Of the 830 sub jects, 600 comp le ted the qu es ti on na i re to de ter mine the so ci o de mog ra pic fe a tu res and smo king sta tus. Ba bi es we re we ig hed by the re se arc hers. Abor ti ons, still birth, pre ma tu re de li very, low birth we ight, placental abruption, pla cen ta pre vi a, ec lamp si a, pre ma tu re rup tu res of the mem bra ne we re de ter mi ned. R Re e s su ul lt ts s: : The me an age was 28.4 ± 5.81 ye ars. The rate of wo men who smo ked at any ti me of the ir preg nancy was 7.3% (n= 44). Com pa red to the ba bi es born to mot hers who did not smo ke du ring preg nancy, ba bi es born to mothers who smo ked du ring preg nancy we re 128.68 g ligh ter. When the fin dings of smo king mot hers we re com pa red to ne ver smo king mot hers, the rates of abor ti on (38.6% ver sus 29.3%), still birth (4.5%-2.7%), pre ma tu re de li very (31.8%-19.1%), low birth we ight (22.7%-18.2%), placental abruption (2.3%-1.6%), and pre ec lamp si a (9.1%-8.6%) we re hig her (p> 0.05). The ra te of pre matu re rup tu re of the mem bra nes among smo ker preg nant wo men was fo und sig ni fi cantly hig her compared to ne ver smo kers (p< 0.05). C Co on nc c l lu u s si i o on n: : Ac cor ding to our fin dings, it is cle ar that smoking du ring preg nancy had ad ver se pe ri na tal out co mes. Preg nant smo kers sho uld be en co u ra ged to qu it smo king. Co un sel ling sho uld be gi ven by he althca re pro fes si o nals at all ti mes. In addition, the part ners who smo ke sho uld be in for med of the risks as well.K Ke ey y W Wo or rd ds s: : Pregnancy; smoking Ö ÖZ ZE ET T A Am ma aç ç: : Bu ça lış ma nın ama cı has ta ne ve ri le ri ne da ya lı ola rak ge be lik sı ra sın da si ga ra iç me yüz de si ve ge be lik te si ga ra içil me si nin pe ri na tal so nuç la rı nı de ğer len dir mek tir.G Ge e r re eç ç v ve e Y Yö ön n t te em m --l le er r: : Bü tün ol gu lar do ğum son ra sı bi rin ci gün de yüz yü ze bir se ri so ru ya ce vap ve re ce ği bil di ri le rek ça lış ma ya alın dı lar. 830 ol gu nun 600'ü si ga ra iç me ve sos yo de mog ra fik özel lik le ri be lir ten bir anke ti ta mam la dı. Be bek ler araş tır ma cı lar ta ra fın dan tar tıl dı lar. Dü şük ler, in tra u te rin ölüm ler, prema tür do ğum lar, dü şük do ğum ağır lı ğı, ab rup ti o pla cen ta, pla cen ta pre vi a, ek lamp si ve er ken mem bran rüp tür le ri be lir le ne rek kay de dil di. B Bu ul l g gu u l la ar r: : Ol gu la rın yaş or ta la ma sı 28.4 ± 5.81 yaş idi. Ge be li ğin her han gi bir za ma nın da si ga ra iç miş olan ka dın la rın yüz de si %7.3 (n= 44) idi. Ge be lik sı -ra sın da an ne ...

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Section: Referencesmentioning

confidence: 51%

Evaluation of Smoking Among Pregnant Women in a Central Anatolian City of Turkey: Comparison with Other Countries

Marakoğlu¹,

Erdem²

2011

Turkiye Klinikleri J Med Sci

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“…Multiple reports demonstrate that prenatal nicotine exposure increases markers of oxidative damage (72)(73)(74), and, similarly, multiple reports also show that maternal smoking during pregnancy increases markers of oxidative damage (75)(76)(77). A fundamental role for reactive oxygen species in mediating the effects of both prenatal nicotine and maternal smoking is the ability of vitamin C supplementation during pregnancy to block both the effects of prenatal nicotine (49,78) and maternal smoking (32) on lung development.…”

Section: Effects Of Prenatal Nicotine Exposure On Lung Development Anmentioning

confidence: 97%

The Role of Nicotine in the Effects of Maternal Smoking during Pregnancy on Lung Development and Childhood Respiratory Disease. Implications for Dangers of E-Cigarettes

Spindel

McEvoy

2016

Am J Respir Crit Care Med

137

107

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Use of e-cigarettes, especially among the young, is increasing at nearexponential rates. This is coupled with a perception that e-cigarettes are safe and with unlimited advertising geared toward vulnerable populations, the groups most likely to smoke or vape during pregnancy. There is now wide appreciation of the dangers of maternal smoking during pregnancy and the lifelong consequences this has on offspring lung function, including the increased risk of childhood wheezing and subsequent asthma. Recent evidence strongly supports that much of the effect of smoking during pregnancy on offspring lung function is mediated by nicotine, making it highly likely that e-cigarette use during pregnancy will have the same harmful effects on offspring lung function and health as do conventional cigarettes. In fact, the evidence for nicotine being the mediator of harm of conventional cigarettes may be most compelling for its effects on lung development. This raises concerns about both the combined use of e-cigarettes plus conventional cigarettes by smokers during pregnancy as well as the use of e-cigarettes by e-cigarette-only users who think them safe or by those sufficiently addicted to nicotine to not be able to quit e-cigarette usage during pregnancy. Thus, it is important for health professionals to be aware of the risks of e-cigarette usage during pregnancy, particularly as it pertains to offspring respiratory health.

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“…Cigarette smoking can lead to oxidative stress for smokers and those exposed to smoking, as well as reduce the level of certain antioxidants (glutathione, vitamins E and C, folate and beta-carotene etc.). However, only contradictory fi ndings are available regarding the effects of smoking on dietary antioxidant and oxidant metabolites in pregnant women (10)(11)(12)(13).…”

mentioning

confidence: 99%

Effects of Smoking during Pregnancy on DNA Damage and ROS Level Consequences in Maternal and Newborns’ Blood

Aydoğan

Durmaz

Ercan

et al. 2013

Archives of Industrial Hygiene and Toxicology

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Some of the genotoxic/carcinogenic substances or metabolites in cigarette smoke are capable of passing through the placenta and harming a newborn's health. Smoking is also known as a factor in the formation of oxidative damage and the main mechanism involved in the carcinogenic process. Predetermining this genotoxic risk can be successfully achieved by measuring certain parameters of oxidative stress. The comet assay is considered an important biomarker for the evaluation of genotoxic substances and is effective for detecting DNA damage caused by smoking. This study examined third trimester bloods and the cord blood of 28 actively smoking and 22 non-smoking mothers in terms of DNA damage and oxidative stress parameters. Cu/Zn superoxide dismutase (CuZn-SOD), malondialdehyde (MDA), catalase (CAT), plasma nitrite/nitrates (NO 2 -/NO 3 -), selenium-dependent glutathione peroxidase (Se-GPx), Cu, and Zn levels were measured as indicators of oxidative damage. There were no signifi cant increases in DNA damage of the actively smoking pregnant group in comparison with the non-smoking pregnant group, either in the third trimester or cord blood. Oxidative stress parameters of smoker and non-smoker groups were statistically different for MDA (p<0.05), CuZn-SOD (p<0.01), Se-GPx (p<0.05) values while the difference was not signifi cant for NO 2 -/NO 3 -, CAT, Zn, and Cu values. The same values were also investigated in cord blood, and only NO 2 /NO 3 -(p<0.01), Se-GPx (p<0.01 and CAT (p<0.001) values were found statistically different. Smoking mothers may have been exposed to more oxidative stress than non-smoking mothers.

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The influence of maternal smoking on maternal and newborn oxidant and antioxidant status

Cited by 60 publications

References 26 publications

Evaluation of Smoking Among Pregnant Women in a Central Anatolian City of Turkey: Comparison with Other Countries

Evaluation of Smoking Among Pregnant Women in a Central Anatolian City of Turkey: Comparison with Other Countries

The Role of Nicotine in the Effects of Maternal Smoking during Pregnancy on Lung Development and Childhood Respiratory Disease. Implications for Dangers of E-Cigarettes

Effects of Smoking during Pregnancy on DNA Damage and ROS Level Consequences in Maternal and Newborns’ Blood

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