The Influence of Maternal Vitamin E Concentrations in Different Trimesters on Gestational Diabetes and Large-for-Gestational-Age: A Retrospective Study in China

Zhou, Qianling; Jiao, Mingyuan; Han, Na; Yang, Wangxing; Bao, Heling; Ren, Zhiguo

doi:10.3390/nu14081629

Cited by 7 publications

(5 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The aforementioned systematic review by Sharifipour et al concluded that the VE level was significantly lower in women with GDM compared to healthy pregnant women [ 18 ]. However, one large retrospective cohort study ( n = 19,647) from China reported that maternal VE concentrations in the first and second trimesters were positively associated with GDM; this study did not exclude pregnant women with pre-gestational diabetes mellitus [ 16 ]. In contrast to previous findings, we found that the association of the first-trimester VE concentration with the GDM risk are presented as a L-shaped curve with an inflexion point around 7 mg/L.…”

Section: Discussionmentioning

confidence: 99%

“…Vitamin E (VE), a well documented antioxidant, can neutralize ROS, eliminate oxygen free radicals, and protect tissue from damage [ 9 , 10 ]. However, although a robust number of studies on the role of VE in the cause and prevention of diabetic complications [ 8 , 11 , 12 , 13 , 14 , 15 ], there are very few studies on its association with risk of diabetes mellitus, especially GDM [ 16 , 17 ]. The systematic review by Sharifipour et al aimed to evaluate the association between VE and GDM, and this only included eleven relevant studies with a total of 596 participants published before December 2019, of which seven were the case-control studies, and the rest were cross-sectional [ 18 ].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Gestational Vitamin E Status and Gestational Diabetes Mellitus: A Retrospective Cohort Study

et al. 2023

View full text Add to dashboard Cite

Objectives: To examine the association between vitamin E (VE) status and gestational diabetes mellitus (GDM). Methods: A retrospective cohort study was conducted by using data of 52,791 women at 137 hospitals across 22 provinces of China. A fasting plasma glucose (FPG) level of ≥5.1 mmol/L between the 24th and 40th weeks of gestation was used as the criteria for the diagnosis of GDM. Mean FPG level and GDM rate were calculated within each combination of the first-trimester VE concentration categories and gestational change categories. The associations of the first-trimester VE concentrations and gestational VE change with FPG and GDM were examined by employing generalized additive models (GAMs). Results: 7162 (13.57%) cases were diagnosed with GDM. The GDM rate was 22.44%, 11.50%, 13.41%, 12.87%, 13.17%, 13.44%, 12.64%, and 14.24% among women with the first-trimester VE concentrations of <7.2, 7.2–7.9, 8.0–9.3, 9.4–11.0, 11.1–13.2, 13.3–15.8, 15.9–17.7, and 17.8–35.9 mg/L, respectively. The GDM rate was 15.96%, 13.10%, 13.64%, and 12.87% among women with gestational VE change of <0, 0–0.19, 0.20–0.29, ≥0.30 mg/L per week, respectively. Multivariable adjusted GAM analyses found that the first-trimester VE concentration was associated with the FPG levels and GDM risk in an L-shaped pattern; the FPG levels and GDM risk decreased sharply to a threshold (around 7 mg/L), and then were keep flat. Gestational VE decreases when the first-trimester VE level was less than 11 mg/L were related to increased FPG levels and GDM risk. Conclusions: Both low first-trimester VE levels and subsequent gestational VE decrease were related with increased risk of GDM. The findings suggest the necessity of having VE-rich foods and appropriate VE supplementation to prevent GDM for pregnant women with low baseline VE levels.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Gestational Vitamin E Status and Gestational Diabetes Mellitus: A Retrospective Cohort Study

et al. 2023

View full text Add to dashboard Cite

show abstract

“…[90] However, other clinical studies have concluded that high vitamin E levels lead to GDM. [91,92] The results of prospective studies suggest that increased intake of vitamin A from animal foods is associated with a reduced risk of GDM and that there is no association between plant vitamin A intake and GDM. [93] Other prospective studies have come to the opposite conclusion, suggesting that high vitamin A levels lead to GDM.…”

Section: Vitaminmentioning

confidence: 99%

Dietary management of gestational diabetes: A review

Long,

Liang

2024

Medicine

View full text Add to dashboard Cite

Gestational diabetes mellitus (GDM) is a common condition in pregnant women that can affect the health of both the mother and the fetus. A healthy diet reduces the risk of GDM, while on the contrary, an unhealthy diet can increase the risk of developing GDM. Dietary interventions remain an important way to control GDM at this time. However, real-life diets are complex and varied, and the effect of these diets on gestational diabetes is unknown. This article summarizes research related to dietary control of GDM. Hopefully, this will help with dietary interventions for people with GDM.

show abstract

“…Recent reports showed that the prevalence of SGA was 19.3% in low‐ and middle‐income countries (Lee et al, 2017 ), 6.5% in European countries (Hocquette et al, 2021 ) and 5.7%–12.3% in China (He et al, 2021 ; Liu et al, 2022 ; Zhu et al, 2022 ). The prevalence of LGA was 16.1% in European countries and 7.1%–17.8% in China (Song et al, 2022 ; Tang, Chen, et al, 2021 ; Zhou et al, 2022 ). Appropriate birthweight is a foundation for good obstetric maternal and foetal outcomes and chronic disease prevention.…”

Section: Introductionmentioning

confidence: 99%

Trajectory of gestational weight gain is related to birthweight: The TAWS cohort study in China

Wang,

Li,

Yang

et al. 2024

Maternal & Child Nutrition

View full text Add to dashboard Cite

Few studies have reported the timing and amount of gestational weight gain (GWG) to prevent large‐for‐gestational‐age (LGA) or small‐for‐gestational‐age (SGA). This study aimed to evaluate the association of GWG velocity in each trimester with LGA or SGA based on data from the Taicang and Wuqiang cohort study (TAWS, n = 2008). We used a linear mixed model to evaluate the association of trimester‐specific GWG velocity with birthweight categories and stratified by prepregnancy body mass index category and parity. For normal‐weight pregnant women, mothers with LGA births had higher GWG velocities than mothers with appropriate‐for‐gestational‐age (AGA) births in the first trimester (0.108 vs. 0.031 kg/week, p < 0.01), second trimester (0.755 vs. 0.631 kg/week, p < 0.01) and third trimester (0.664 vs. 0.594 kg/week, p < 0.01); in contrast, mothers with SGA births had lower GWG velocities than mothers with AGA births in the second trimester (0.528 vs. 0.631 kg/week, p < 0.01) and third trimester (0.541 vs. 0.594 kg/week, p < 0.01). For normal‐weight pregnant women with AGA births, multiparous women had lower GWG velocities than primiparous women in the second (0.602 vs. 0.643 kg/week, p < 0.01) and third trimesters (0.553 vs. 0.606 kg/week, p < 0.01). Therefore, for normal‐weight women, LGA prevention would begin in early pregnancy and continue until delivery and the second and third trimesters may be critical periods for preventing SGA; in addition, among normal‐weight pregnant women with AGA births, multiparous women tend to have lower weight gain velocities than primiparous women.

show abstract

The Influence of Maternal Vitamin E Concentrations in Different Trimesters on Gestational Diabetes and Large-for-Gestational-Age: A Retrospective Study in China

Cited by 7 publications

References 27 publications

Gestational Vitamin E Status and Gestational Diabetes Mellitus: A Retrospective Cohort Study

Gestational Vitamin E Status and Gestational Diabetes Mellitus: A Retrospective Cohort Study

Dietary management of gestational diabetes: A review

Trajectory of gestational weight gain is related to birthweight: The TAWS cohort study in China

Contact Info

Product

Resources

About