The influence of mechanical stress on graft healing in a bone tunnel

Yamakado, Kotaro; Kitaoka, Katsuhiko; Yamada, Hiroshi; Hashiba, Kazuhiko; Nakamura, Ryuichi; Tomita, Katsuro

doi:10.1053/jars.2002.25966

Cited by 85 publications

(65 citation statements)

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“…In this study, abundant bone formation around the tendon was observed in the BMSC(+) group 6 weeks after the operation, and collagen continuity between the tendon and fibrous tissue in the pores and direct apposition of tendon to bone were observed in some pores; however, a fibrocartilagenous layer and penetrating collagen fibres were not observed in the interface. Yamakado et al reported in their animal study that tensile stress enhanced the healing process at the tendon-bone junction [14]. In our model, the tendon was pulled medially through the hole in the IP-CHA and the bone tunnel and sutured to the medial collateral ligament, but the tensile stress in the joint motion was not obtained to the tendon.…”

Section: Discussionmentioning

confidence: 83%

Augmentation of tendon attachment to porous ceramics by bone marrow stromal cells in a rabbit model

Omae

Mochizuki

Yokoya

et al. 2006

International Orthopaedics (SICOT)

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Tendon attachment to interconnected porous calcium hydroxyapatite ceramics (IP-CHA) with cultured bone marrow stromal cells (BMSC) was analysed. The purpose of this study was to evaluate whether BMSC in IP-CHA could augment the tendon attachment to IP-CHA histologically and biomechanically. Eighteen Japanese white rabbits were used. Cultured BMSCs were subcultured in IP-CHA. The grafted tendon and IP-CHA with BMSC complex were implanted in a bone defect of the knee [BMSC(+) group]. In the contralateral knee, a tendon and IP-CHA without BMSC complex were implanted [BMSC(-) group]. Histological findings of the interface between the tendon and IP-CHA were similar in the two groups 3 weeks after the operation. However, 6 weeks after the operation, more abundant bone formation around the tendon was observed in the BMSC (+) group. The direct apposition of the tendon to bone in pores and collagen fibre continuity between the tendon and fibrous tissue in pores were observed. In biomechanical evaluation, the maximum pull-out load of the tendon from the IP-CHA in the BMSC(+) group was significantly higher than that in the BMSC(-) group 6 weeks after the operation. BMSCs cultured in IP-CHA could augment tendon attachment to IP-CHA. Résumé Le propos de cette étude est de déterminer si l'utilisation de culture cellulaire de moelle osseuse (BMSC) avec l'utilisation de calcium d'hydroxyapatite (IP-CHA) augmente la résistance de l'attachement osseux du tendon sur le plan histologique et biomécanique. Dix-huit lapins blancs du Japon ont été utilisés pour ce travail. Les tendons greffés avec hydroxyapatite et culture de la cellule de moelle osseuse ont été implantés dans une defect au niveau du genou. Sur le genou opposé, le tendon a été implanté sans culture cellulaire. Sur le plan histologique les résultats sont identiques dans les deux groupes, 3 semaines après intervention, cependant 6 semaines après l'intervention la progression de la formation osseuse est plus importante autour du tendon ayant bénéficié d'une culture cellulaire de moelle osseuse. Il en est de même en ce qui concerne la résistance biomécanique du tendon qui est significativement plus importante dans le groupe culture cellulaire, 6 semaines après l'intervention.

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Section: Discussionmentioning

confidence: 83%

Augmentation of tendon attachment to porous ceramics by bone marrow stromal cells in a rabbit model

Omae

Mochizuki

Yokoya

et al. 2006

International Orthopaedics (SICOT)

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“…All samples were scored according to the scoring system described by Yamakado et al [21] ( Table I). The histological scores of the group sacrificed in the sixth week showed no significant differences between the two groups in terms of the amount of collagen formation and maturation at the enthesis (p>0.05).…”

Section: Histological Resultsmentioning

confidence: 99%

“…All histopathological examinations were performed via a binocular research microscope Olympus BX51 (Olympus, Tokyo, japan) and microphotographs were taken with Olympus DP25 digital microscope camera (Olympus, Tokyo, Japan). Histologic changes for each case was scored semi quantitatively in respect to Yamakado et al [21] scoring criteria and evaluated according to a range from 0 to 3 points depending on the severity and extent of changes.…”

Section: Histological Evaluationmentioning

confidence: 99%

Glucosamine-chondroitin sulphate accelerates tendon-to-bone healing in rabbits

Taşkesen

Ataoğlu

Özer

et al. 2015

Eklem Hastalik Cerrahisi

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“…Yamakado et al, using an extra-articular tendon-to-bone canine model with suspensory fixation, showed that patterns of tendon to bone healing in different portions of the bone tunnel were related to stress distribution. Tensile stress enhances the healing process of tendon-bone junctions, compressive stress promotes chondroid formation and shear load has little or no effect on regeneration of the tendon-bone junction [22].…”

Section: Discussionmentioning

confidence: 99%

“…The specimens sectioned parallel to the longitudinal axis of the bone tunnel were stained with haematoxylin and eosin, Sirius red and Masson trichrome for light microscopy. According to Yamakado's classification [22], interface tissue at the tendon-bone junction was graded morphologically in terms of separation between bone and tendon, interface without collagen fibre continuity, Sharpey's fibre continuity (indirect connection) and direct type of insertion. Each group had ten specimens (five tibial and five femoral) in the observation time.…”

Section: Histological Observationmentioning

confidence: 99%