The Influence of Menstrual Phases on Pain Modulation in Healthy Women

Rezaii, Taraneh; Hirschberg, Angelica Lindén; Carlström, Kjell; Ernberg, Malin

doi:10.1016/j.jpain.2012.04.002

Cited by 91 publications

(76 citation statements)

References 41 publications

(33 reference statements)

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“…Because some of the migraineurs took OC, which might have affected the menstrual cycle, we repeated these analyses in healthy women free of OC and found that the menstrual cycle neither affected CPM effects on pain nor on detection thresholds. These findings are in contrast to the findings of Tousignant-Laflamme and Marchand, (2009) and Rezaii et al (2012). Tousignant-Laflamme & Marchand (2009) demonstrated that inhibitory but not excitatory pain mechanisms varied over the menstrual cycle.…”

Section: Cpm and Menstrual Variationcontrasting

confidence: 99%

“…This might explain why Tousignant-Laflamme and Marchand (2009) and Rezaii et al (2012) found menstrualdependent CPM effects and we did not. The former authors both used a similar paradigm with CPT for conditioning stimulation, which also leads to strong autonomic reactions, and pressure as test stimulus, and this differs from ours.…”

Section: Cpm and Menstrual Variationcontrasting

confidence: 59%

“…Interestingly, the menstrual cycle has not only been shown to impact the occurrence of migraine but also to influence CPM inhibition, with more pronounced CPM effects during the ovulatory phase in healthy women (Tousignant-Laflamme and Marchand, 2009;Rezaii et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

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Endogenous pain inhibition during menstrual cycle in migraine

Teepker

Kunz

Peters

et al. 2014

European Journal of Pain

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Background: Migraine is a common headache disorder that can vary menstrually in women and has been linked to an impairment of endogenous pain inhibitory systems. One of these endogenous pain inhibitory systems, namely conditioned pain modulation (CPM; formerly diffuse noxious inhibitory controls-like), has been shown to be affected by the menstrual cycle. The aim of this study was to examine CPM over the menstrual cycle in migraineurs and healthy controls. Methods: Twenty healthy women and 32 female migraineurs were examined on days 1, 4, 14 and 22 of the menstrual cycle. Detection and pain thresholds for electrocutaneous stimuli were first assessed at baseline. Second, tonic heat stimuli were applied concurrently to the electrical stimuli, and the difference in electrical thresholds to baseline were analysed as indicating CPM inhibition. Results: Migraineurs revealed higher detection thresholds than the control group but similar pain thresholds for the electrical current. Likewise, pain sensitivity for tonic heat stimulation also did not differ between groups. With regard to our main hypotheses, we found that CPM inhibition neither differed between migraineurs and healthy volunteers nor varied over the menstrual cycle. Conclusions: Our findings suggest that CPM inhibition is not altered in female migraineurs; thus, it is questionable whether CPM really plays a role in the development of migraine or whether migraine leads to a dysfunctional CPM inhibition.

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Section: Cpm and Menstrual Variationcontrasting

confidence: 99%

Section: Cpm and Menstrual Variationcontrasting

confidence: 59%

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Endogenous pain inhibition during menstrual cycle in migraine

Teepker

Kunz

Peters

et al. 2014

European Journal of Pain

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show abstract

“…Evidence shows that to examine the influence of female sex hormone on pain perception, a correct determination of menstrual cycle phase (follicular, ovulatory, and mid-luteal) should be based on the serum sex hormone levels analysis and not simple recording of timing of menstrual cycle. 22 Thus, future studies in this direction might better assess the status of menstrual cycle on pain perception based on the analysis of serum sex hormone level rather than just timing of the menstrual cycle.…”

Section: Limitations and Future Directionsmentioning

confidence: 99%

Orthodontic pain trajectories in adolescents: Between-subject and within-subject variability in pain perception

Sandhu¹,

Leckie

2016

American Journal of Orthodontics and Dentofacial Orthopedics

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“…Further, they did not study pain during the ovulatory phase, which is associated with enhanced pain inhibition in women without PMDD. 19,20 Thus, it is unclear whether a sex hormone/pain relationship would be found with a more comprehensive assessment of pain and hormones.…”

mentioning

confidence: 99%

Nociceptive Processing in Women With Premenstrual Dysphoric Disorder (PMDD)

Bartley

Palit

Kuhn

et al. 2015

The Clinical Journal of Pain

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Overall, women with PMDD may have a phase-independent hyperalgesia, with pain amplification likely occurring at the supraspinal level rather than the spinal level, given the lack of group differences in NFR threshold. Because testosterone was hypoalgesic and lower in women with PMDD, and there were strong associations between pain and estradiol in PMDD, sex hormones may play a role in PMDD-related hyperalgesia.

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The Influence of Menstrual Phases on Pain Modulation in Healthy Women

Cited by 91 publications

References 41 publications

Endogenous pain inhibition during menstrual cycle in migraine

Endogenous pain inhibition during menstrual cycle in migraine

Orthodontic pain trajectories in adolescents: Between-subject and within-subject variability in pain perception

Nociceptive Processing in Women With Premenstrual Dysphoric Disorder (PMDD)

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