The Influence of Microbial Metabolites in the Gastrointestinal Microenvironment on Anticancer Immunity

Neumann, Silke; Peyroux, Estelle M.; Woodall, Matthew J; Shields, Nicholas J.; Young, Sarah L.

doi:10.5772/intechopen.88137

Cited by 4 publications

(4 citation statements)

References 192 publications

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“…Another example is the important role of indole derivatives, produced by gut bacteria from the degradation of tryptophan, such as aryl hydrocarbon receptor ligands, to maintain intestinal homeostasis, limit inflammation and thus, indirectly reduce the risk of colorectal, prostate and breast cancer (127)(128)(129). Finally, short-chain fatty acids are produced by the gut microbiome through fermentation of nondigestible fiber and starch and help maintain balance between intestinal immunity and inflammation (130,131). As such, microbiota may influence the risk of many cancers, independent of anatomic location due to effects of microbial metabolites on inflammation, an important hallmark of cancer, and other metabolic conditions associated with cancer risk.…”

Section: Barriers and Challenges In Microbiome Studiesmentioning

confidence: 99%

The Human Microbiome in Relation to Cancer Risk: A Systematic Review of Epidemiologic Studies

Huybrechts

Zouiouich

Loobuyck

et al. 2020

Cancer Epidemiology, Biomarkers &Amp; Prevention

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The microbiome has been hypothesized to play a role in cancer development. Because of the diversity of published data, an overview of available epidemiologic evidence linking the microbiome with cancer is now needed. We conducted a systematic review using a tailored search strategy in Medline and EMBASE databases to identify and summarize the current epidemiologic literature on the relationship between the microbiome and different cancer outcomes published until December 2019. We identified 124 eligible articles. The large diversity of parameters used to describe microbial composition made it impossible to harmonize the different studies in a way that would allow metaanalysis, therefore only a qualitative description of results could be performed. Fifty studies reported differences in the gut microbiome between patients with colorectal cancer and various control groups. The most consistent findings were for Fusobacterium, Porphyromonas, and Peptostreptococcus being significantly enriched in fecal and mucosal samples from patients with colorectal cancer. For the oral microbiome, significantly increased and decreased abundance was reported for Fusobacterium and Streptococcus, respectively, in patients with oral cancer compared with controls. Overall, although there was a large amount of evidence for some of these alterations, most require validation in high-quality, preferably prospective, epidemiologic studies.

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Section: Barriers and Challenges In Microbiome Studiesmentioning

confidence: 99%

The Human Microbiome in Relation to Cancer Risk: A Systematic Review of Epidemiologic Studies

Huybrechts

Zouiouich

Loobuyck

et al. 2020

Cancer Epidemiology, Biomarkers &Amp; Prevention

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“…Many of these metabolites are taken up into host circulation and eventually into various tissues to participate in endogenous metabolism. Notably, the effect of microbial compounds within the mammalian host environment varies from one tissue to another based on the type and metabolic status of affected tissues [40][41][42]. Metabolomics is a well-established and powerful tool that can be applied to identify microbiomederived or microbiome-modified metabolites and to better understand the modulation of microbiota and how it affects the metabolism in a host [43,44].…”

Section: Introductionmentioning

confidence: 99%

Tissue-wide metabolomics reveals wide impact of gut microbiota on mice metabolite composition

Zarei

Koistinen

Kokla

et al. 2021

Preprint

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The essential role of gut microbiota in health and disease is well-recognized, but the biochemical details underling beneficial impact remain largely undefined. Dysbiosis of gut bacteria results in the alteration of certain microbial and host metabolites, and identifying these markers could enhance the early detection of certain diseases. We report LC-MS based non-targeted metabolic profiling to demonstrate a large effect of gut microbiota on mammalian tissue metabolites. It was hypothesized that gut microbiota influences the overall biochemistry of the host metabolome and this effect is tissue-specific. Thirteen different tissues from germ-free and conventional mice were selected and their metabolic differences were analyzed. Our study demonstrated a large effect of the microbiome on mammalian biochemistry at different tissue levels and resulted in significant modulation of metabolites from multiple metabolic pathway (p ≤ 0.05). A vast metabolic response of host to metabolites generated by the microbiota was observed, Hundreds of molecular features were detected exclusively in one mouse group, with the majority of these being unique to specific tissue, suggesting direct impact gut microbiota on host metabolism.

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“…Many of these metabolites are taken up into host circulation and eventually into various tissues to participate in endogenous metabolism. Notably, the effect of microbial compounds within the mammalian host environment varies from one tissue to another based on the type and metabolic status of affected tissues [40][41][42]. Metabolomics is a well-established and powerful tool that can be applied to identify microbiome-derived or microbiome-modi ed metabolites and to better understand the modulation of microbiota and how it affects the metabolism in a host [43,44].…”

Section: Introductionmentioning

confidence: 99%

Tissue-wide Metabolomics Reveals Wide Impact of Gut Microbiota on Mice Metabolite Composition

Zarei

Koistinen

Kokla

et al. 2021

Preprint

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BackgroundThe essential role of gut microbiota in health and disease is well recognized, but the biochemical details that underlie the beneficial impact remain largely undefined. To maintain its stability, microbiota participates in an interactive host-microbiota metabolic signaling, impacting the metabolic phenotypes of the host. Dysbiosis of gut bacteria results in the alteration of certain microbial and host metabolites, and identifying these markers could enhance the early detection of certain diseases. Herein, we report LC-MS based non-targeted metabolic profiling that demonstrates a large effect of gut microbiota on mammalian tissue metabolites. It was hypothesized that gut microbiota influences the overall biochemistry of the host metabolome and this effect is tissue-specific. ResultsThirteen different tissues from germ-free (GF) and conventional (MPF) C57BL/6NTac mice were selected and their metabolic differences were analyzed. Our study demonstrated a large effect of the microbiome on mammalian biochemistry at different tissue levels and resulted in statistically significant modulation of metabolites from multiple metabolic pathway and subpathway classifications (p ≤ 0.05). Hundreds of molecular features were detected exclusively in one mouse group, with the majority of these being unique to specific tissue. A significantly large number of chemical classes were found in the gastrointestinal tissues and arose because of the presence of the microbiome, wherein at least 59% of all detectable features vary in abundance between the two mouse lines. ConclusionsA vast metabolic response of host to metabolites generated by the microbiota was observed, suggesting that the gut microbiota has a direct impact on host metabolism.

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The Influence of Microbial Metabolites in the Gastrointestinal Microenvironment on Anticancer Immunity

Cited by 4 publications

References 192 publications

The Human Microbiome in Relation to Cancer Risk: A Systematic Review of Epidemiologic Studies

The Human Microbiome in Relation to Cancer Risk: A Systematic Review of Epidemiologic Studies

Tissue-wide metabolomics reveals wide impact of gut microbiota on mice metabolite composition

Tissue-wide Metabolomics Reveals Wide Impact of Gut Microbiota on Mice Metabolite Composition

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