The influence of microenvironment stiffness on endothelial cell fate: Implication for occurrence and progression of atherosclerosis

Cheng, Lin; Yue, Hongyan; Zhang, Huaiyi; Liu, Qiao; Du, Lingyu; Liu, Xiaoheng; Xie, Jing; Shen, Yang

doi:10.1016/j.lfs.2023.122233

Cited by 6 publications

(1 citation statement)

References 167 publications

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“…For example, blood arteries undergo stiffening and lose their elasticity with age. Reports have shown that the ECM stiffening could influence the fate of endothelial cells by changing the cell adhesion, spreading, proliferation, cell-to-cell contact, migration, and even communication with smooth muscle cells [110]. Because the ECM is a highly dynamic structure that constantly undergoes remodeling, changes in the physical microenvironment of ECM play a significant role in endothelial cell viability [110].…”

Section: Effect Of Arterial Stiffening On Endothelial Mechanosensingmentioning

confidence: 99%

Shear Stress and Endothelial Mechanotransduction in Trauma Patients with Hemorrhagic Shock: Hidden Coagulopathy Pathways and Novel Therapeutic Strategies

Chalkias

2023

IJMS

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Massive trauma remains a leading cause of death and a global public health burden. Post-traumatic coagulopathy may be present even before the onset of resuscitation, and correlates with severity of trauma. Several mechanisms have been proposed to explain the development of abnormal coagulation processes, but the heterogeneity in injuries and patient profiles makes it difficult to define a dominant mechanism. Regardless of the pattern of death, a significant role in the pathophysiology and pathogenesis of coagulopathy may be attributed to the exposure of endothelial cells to abnormal physical forces and mechanical stimuli in their local environment. In these conditions, the cellular responses are translated into biochemical signals that induce/aggravate oxidative stress, inflammation, and coagulopathy. Microvascular shear stress-induced alterations could be treated or prevented by the development and use of innovative pharmacologic strategies that effectively target shear-mediated endothelial dysfunction, including shear-responsive drug delivery systems and novel antioxidants, and by targeting the venous side of the circulation to exploit the beneficial antithrombogenic profile of venous endothelial cells.

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Section: Effect Of Arterial Stiffening On Endothelial Mechanosensingmentioning

confidence: 99%

Shear Stress and Endothelial Mechanotransduction in Trauma Patients with Hemorrhagic Shock: Hidden Coagulopathy Pathways and Novel Therapeutic Strategies

Chalkias

2023

IJMS

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Remodelers of the vascular microenvironment: The effect of biopolymeric hydrogels on vascular diseases

Li,

Jin,

Yang

2024

International Journal of Biological Macromolecules

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SAL protects endothelial cells from H2O2-induced endothelial dysfunction: Regulation of inflammation and autophagy by EZH2

Sun,

Li,

Zhang

et al. 2024

International Immunopharmacology

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The influence of microenvironment stiffness on endothelial cell fate: Implication for occurrence and progression of atherosclerosis

Cited by 6 publications

References 167 publications

Shear Stress and Endothelial Mechanotransduction in Trauma Patients with Hemorrhagic Shock: Hidden Coagulopathy Pathways and Novel Therapeutic Strategies

Shear Stress and Endothelial Mechanotransduction in Trauma Patients with Hemorrhagic Shock: Hidden Coagulopathy Pathways and Novel Therapeutic Strategies

Remodelers of the vascular microenvironment: The effect of biopolymeric hydrogels on vascular diseases

SAL protects endothelial cells from H2O2-induced endothelial dysfunction: Regulation of inflammation and autophagy by EZH2

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