This research investigated the intricate interplay between macroeconomic variables and money supply within Nepal's economic landscape. The primary objective was to comprehensively explore the influence of various macroeconomic factors on money supply dynamics, encompassing trends, correlations, and impacts. Utilizing data from Nepal Rastra Bank, IMF, and World Bank, collected over a sample period from 1992 to 2022, the study employed descriptive and inferential analysis, utilizing SPSS version 25 software. The findings highlighted significant fluctuations in money supply driven by GDP growth, inflation, exchange rates, and interest rates. While GDP growth exhibited diverse trends, lending rates, inflation, and exchange rates displayed notable fluctuations. Correlations unveiled a significant positive link between money supply and the inflation rate, along with changes in the USD exchange rate. Regression analysis underscored the impact of GDP growth, inflation, USD fluctuations, lending, and deposit rates on changes in money supply. The implications were far-reaching, offering policymakers insights for effective monetary policies, aiding financial institutions and businesses in adapting investment strategies, and paving the way for future cross-country comparative analyses. This research's holistic exploration advanced informed decision-making, facilitating sustainable economic growth in Nepal.