The influence of NAFLD on the risk of atherosclerosis and cardiovascular diseases

Wójcik-Cichy, Kamila; Koślińska-Berkan, Ewa; Piekarska, Anna

doi:10.5114/ceh.2018.73155

Cited by 66 publications

(49 citation statements)

References 69 publications

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“…Associations between NAFLD and atherosclerosis have been reported in several large epidemiology studies [3,20,21]. However, few studies have investigated whether the two diseases share any common pathophysiological mechanisms, which would suggest that they may respond to the same therapy.…”

Section: Discussionmentioning

confidence: 99%

RecombinantLactococcus lactisExpressing Ling Zhi 8 Protein Ameliorates Nonalcoholic Fatty Liver and Early Atherogenesis in Cholesterol-Fed Rabbits

Lee

Chiang

Lin

et al. 2020

BioMed Research International

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Atherosclerosis is an inflammatory disease characterized by lipid deposits in the subendothelial space leading to severe inflammation. Nonalcoholic fatty liver disease (NAFLD) shares several risk factors with atherosclerosis, including dyslipidemia, type 2 diabetes mellitus, and metabolic syndrome, all of which lead to lipid deposition in the liver causing inflammation and fibrosis. Several clinical trials have shown that certain Chinese herbal medicines with anti-inflammatory effects can be used as adjuvant therapy to prevent the development of cardiovascular events and liver disease. Ling Zhi 8 (LZ8) is an immunomodulatory protein isolated from a medicinal mushroom and has been well documented to possess a broad range of pharmacological properties. This study aimed to evaluate the protective effects of recombinant Lactococcus lactis expressing LZ8 protein on NAFLD and atherogenesis in a cholesterol-fed rabbit model. Twelve rabbits were divided into three groups and fed with syrup only, L. lactis vehicle, or recombinant L. lactis-LZ8 once a day on weekdays for five weeks, respectively. The gene expression of IL-1β in the aorta was significantly suppressed after oral administration of L. lactis-LZ8. Moreover, in hematoxylin and eosin staining of the aorta, the intima-medial thickness was decreased, and foam cells were significantly reduced in the subendothelial space. LZ8 also inhibited the expression of IL-1β in the liver, decreased fat droplet deposits and infiltration of inflammatory cells, and improved liver function by decreasing liver enzymes in an animal model. Our results suggest that the Lactococcus-expressing LZ8 appears to be a promising medicine for improving both NAFLD and early atherogenesis owing to its anti-inflammatory effect. Furthermore, it is available as a low-cost food-grade product.

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Section: Discussionmentioning

confidence: 99%

RecombinantLactococcus lactisExpressing Ling Zhi 8 Protein Ameliorates Nonalcoholic Fatty Liver and Early Atherogenesis in Cholesterol-Fed Rabbits

Lee

Chiang

Lin

et al. 2020

BioMed Research International

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“…The occurrence rate of coronary artery disease (CAD) increased 4.7 times in the adult NAFLD population and the severity of CAD was also signi cantly associated with the presence of NAFLD [6]. Multiple factors contribute to the pathogenesis of NAFLD and CAD [7]. Accumulated evidence suggested that gene polymorphism is an important risk factor not only for the occurrence of NAFLD or CAD in the general population, but also for the occurrence of CAD in the NAFLD patients [3,8].…”

Section: Introductionmentioning

confidence: 99%

Association of AGT rs2493132 Polymorphism and the Risk of Coronary Artery Disease in Patients with Non-alcoholic Fatty Liver Disease in Chinese Han Population

Dong

Zhang

et al. 2020

Preprint

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Background: Previous studies proved that AGT gene polymorphisms were associated with the serum lipids metabolism; however, it is not clear whether AGT rs2493132 increases the risk of NAFLD and CAD. This study was designed to investigate the relationship between AGT rs2493132 gene polymorphism and the developing risk of NAFLD and CAD in Chinese Han population.Methods: A total of 142 NAFLD patients, 109 NAFLD + CAD patients, and 246 health controls were included in this study. PCR method was used to measure AGT genotype. The anthropometric and clinical data were measured in clinical laboratory department of Qingdao Municipal Hospital. Statistical analyzes were conducted using the SPSS statistical software, version 21.0. Results: The AGT rs2493132 CT + TT genotype was an important risk factor for CAD in patients with NAFLD (OR = 1.785; 95%CI: 1.061-3.003; P = 0.029), and the risk of CAD in patients with NAFLD was still marked after adjusted for gender, age, and BMI (OR = 4.718; 95%CI: 1.502-14.824; P = 0.008). The T allele of AGT rs2493132 also significantly increased the risk of CAD in NAFLD patients (OR = 2.436; 95% CI: 1.184-5.011, P = 0.016) after adjusted for age, gender, and BMI. In addition, AGT rs2493132 T allele carriers possess the higher TC and LDL levels compared to the non-carriers in all the participants (Both P < 0.05).Conclusions: AGT rs2493132 CT + TT genotype and T allele significantly increased the developing risk of CAD in the patients with NAFLD in Chinese Han population. AGT rs2493132 T allele associated with the increased serum TC and LDL levels.

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“…NAFLD is an independent risk factor for type 2 diabetes and cardiovascular disease, and emerging evidence suggests that NAFLD may influence bone density in adults, since the liver produces factors that affect bone health . Previous evidence also suggests that more severe liver disease in NAFLD may be associated with more pronounced reductions in bone density, since a recent study of 231 adult patients with NAFLD showed that liver fibrosis (assessed by transient elastography) was independently associated with low bone mineral density (BMD) .…”

Section: Introductionmentioning

confidence: 99%

Relationship between non‐alcoholic steatohepatitis, PNPLA3 I148M genotype and bone mineral density in adolescents

Mosca

Fintini

Scorletti

et al. 2018

Liver International

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The influence of NAFLD on the risk of atherosclerosis and cardiovascular diseases

Cited by 66 publications

References 69 publications

RecombinantLactococcus lactisExpressing Ling Zhi 8 Protein Ameliorates Nonalcoholic Fatty Liver and Early Atherogenesis in Cholesterol-Fed Rabbits

RecombinantLactococcus lactisExpressing Ling Zhi 8 Protein Ameliorates Nonalcoholic Fatty Liver and Early Atherogenesis in Cholesterol-Fed Rabbits

Association of AGT rs2493132 Polymorphism and the Risk of Coronary Artery Disease in Patients with Non-alcoholic Fatty Liver Disease in Chinese Han Population

Relationship between non‐alcoholic steatohepatitis, PNPLA3 I148M genotype and bone mineral density in adolescents

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