The influence of nociceptive and neuropathic pain states on the processing of acute electrical nociceptive stimulation: A dynamic causal modeling study

Goudman, Lisa; Marinazzo, Daniele; Steen, Frederik Van de; Nagels, Guy; Smedt, Ann De; Huysmans, Eva; Putman, Koen; Buyl, Ronald; Ickmans, Kelly; Nijs, Jo; Coppieters, Iris; Moens, Maarten

doi:10.1016/j.brainres.2020.146728

Cited by 4 publications

(5 citation statements)

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“… 69 , 70 Non-invasive brain stimulation of the DLPFC can reduce somatosensory cortical excitability in sustained pain, 71 and a dynamic causal model of pain processing found an additional forward and backward connection between S1 and right DLPFC in chronic pain but not HCs, which they proposed could reflect increased attention to and catastrophizing of pain. 72 Although we did not find any correlation of the S1-DLPFC FC with symptom or pain scores pre-operatively, it is possible that such a relationship may exist with other individual factors such as pain catastrophizing. Therefore, it is possible that enhanced S1-DLPFC FC before surgery reflects greater attention to abnormal sensory signals from the hand.…”

Section: Discussioncontrasting

confidence: 67%

Carpal tunnel surgery dampens thalamocortical and normalizes corticocortical functional connectivity

Osborne

Anastakis

Kim

et al. 2022

Brain Communications

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Carpal tunnel syndrome is the most common entrapment neuropathy and is associated with altered brain function and structure. However, little is understood of the central mechanisms associated with its pain, symptom presentation and treatment-related resolution. This longitudinal study evaluated carpal tunnel syndrome-related alterations in brain network communication and relationships to behavioural signs of central sensitization before and after carpal tunnel release surgery. We tested the hypothesis that carpal tunnel syndrome is associated with condition- and treatment-related plasticity in brain regions involved in somatosensation. We used quantitative sensory testing and clinical and pain questionnaires to assess sensory and pain function in 25 patients with carpal tunnel syndrome before (18 women, 7 men) and after (n = 16) surgery, and 25 sex- and age-matched healthy controls. We also acquired resting state functional MRI to determine functional connectivity of two key nodes in the somatosensory system, the thalamus and primary somatosensory cortex. Seed-to-whole brain static resting state static functional connectivity analyses revealed abnormally low functional connectivity for the hand area of the primary somatosensory cortex with the contralateral somatosensory association cortex (supramarginal gyrus) before surgery (P < 0.01). After clinically effective surgery: 1) Primary somatosensory functional connectivity was normalized with the contralateral somatosensory association cortex, and reduced with the dorsolateral prefrontal cortex (a region associated with cognitive and emotional modulation of pain) and primary visual areas (P < 0.001) from pre-op levels; and 2) Functional connectivity of the thalamus with the primary somatosensory and motor cortices was attenuated from pre-op levels (P < 0.001), but did not correlate with temporal summation of pain (a behavioural measure of central sensitization) or clinical measures. This study is the first to reveal treatment-related neuroplasticity in resting state functional connectivity of the somatosensory system in carpal tunnel syndrome. The findings of dysfunctional resting state functional connectivity point to aberrant neural synchrony between the brain’s representation of the hand with regions involved in processing and integrating tactile and nociceptive stimuli and proprioception in carpal tunnel syndrome. Aberrant neural communication between the primary somatosensory hand area and the dorsolateral prefrontal cortex could reflect increased attention to pain, paraesthesia and altered sensation in the hand. Finally, reduced thalamocortical functional connectivity after surgery may reflect central plasticity in response to the resolution of abnormal sensory signals from the periphery. Our findings support the concept of underlying brain contributions to this peripheral neuropathy, specifically aberrant thalamocortical and corticocortical communication, and point to potential central therapeutic targets to complement peripheral treatments.

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Section: Discussioncontrasting

confidence: 67%

Carpal tunnel surgery dampens thalamocortical and normalizes corticocortical functional connectivity

Osborne

Anastakis

Kim

et al. 2022

Brain Communications

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“…2. 2) FC-PC: This is the most frequent effective connectivity category in the literatures, with 80 publications [4], [8][9][10][11][12][13][14][15][16], [18][19][20], [21][22][23][24], [27][28][29], [31][32], [34], [36][37][38][39][40][41][42][43], [46], [55][56][57] , [62 ] , [67 ] , [71 -74 ] , [76][77], [79], [81][82][83], , [107][108][109][110][111][112][113][114][115]…”

Section: Resultsmentioning

confidence: 99%

“…11) FC-INS: Nine papers, [31], [35], [63], [72], [80], [111], [129], [132], [146], involved in this connectivity category, with a heterogeneous set of task types (please refer to Fig. 2 for more details).…”

Section: Resultsmentioning

confidence: 99%

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Dynamic Causal Modeling on the Identification of Interacting Networks in the Brain: A Systematic Review

Wang

Liang

2021

IEEE Trans. Neural Syst. Rehabil. Eng.

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Dynamic causal modeling (DCM) has long been used to characterize effective connectivity within networks of distributed neuronal responses. Previous reviews have highlighted the understanding of the conceptual basis behind DCM and its variants from different aspects. However, no detailed summary or classification research on the task-related effective connectivity of various brain regions has been made formally available so far, and there is also a lack of application analysis of DCM for hemodynamic and electrophysiological measurements. This review aims to analyze the effective connectivity of different brain regions using DCM for different measurement data. We found that, in general, most studies focused on the networks between different cortical regions, and the research on the networks between other deep subcortical nuclei or between them and the cerebral cortex are receiving increasing attention, but far from the same scale. Our analysis also reveals a clear bias towards some task types. Based on these results, we identify and discuss several promising research directions that may help the community to attain a clear understanding of the brain network interactions under different tasks.

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“…However, a recent EEG study measured the brain responses to nociceptive stimulation and revealed significant differences in coupling strengths between patients with nociceptive and neuropathic etiologies. Their findings provided positive evidence for finding potential neuroimaging biomarkers of cLBP subtypes (Goudman et al, 2020). We believe that dynamic FC has the potential to provide new biomarkers in future studies in FBSS, better patient selections for SCS treatments, and/or the mechanisms of SCS.…”

Section: Discussionmentioning

confidence: 78%

Case report: The promising application of dynamic functional connectivity analysis on an individual with failed back surgery syndrome

et al. 2022

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Failed back surgery syndrome (FBSS), a chronic neuropathic pain condition, is a common indication for spinal cord stimulation (SCS). However, the mechanisms of SCS, especially its effects on supraspinal/brain functional connectivity, are still not fully understood. Resting state functional magnetic resonance imaging (rsfMRI) studies have shown characteristics in patients with chronic low back pain (cLBP). In this case study, we performed rsfMRI scanning (3.0 T) on an FBSS patient, who presented with chronic low back and leg pain following her previous lumbar microdiscectomy and had undergone permanent SCS. Appropriate MRI safety measures were undertaken to scan this subject. Seed-based functional connectivity (FC) was performed on the rsfMRI data acquired from the FBSS subject, and then compared to a group of 17 healthy controls. Seeds were identified by an atlas of resting state networks (RSNs), which is composed of 32 regions grouped into 8 networks. Sliding-window method and k-means clustering were used in dynamic FC analysis, which resulted in 4 brain states for each group. Our results demonstrated the safety and feasibility of 3T MRI scanning in a patient with implanted SCS system. Compared to the brain states of healthy controls, the FBSS subject presented very different FC patterns in less frequent brain states. The mean dwell time of brain states showed distinct distributions: the FBSS subject seemed to prefer a single state over the others. Although future studies with large sample sizes are needed to make statistical conclusions, our findings demonstrated the promising application of dynamic FC to provide more granularity with FC changes associated with different brain states in chronic pain.

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The influence of nociceptive and neuropathic pain states on the processing of acute electrical nociceptive stimulation: A dynamic causal modeling study

Cited by 4 publications

References 58 publications

Carpal tunnel surgery dampens thalamocortical and normalizes corticocortical functional connectivity

Carpal tunnel surgery dampens thalamocortical and normalizes corticocortical functional connectivity

Dynamic Causal Modeling on the Identification of Interacting Networks in the Brain: A Systematic Review

Case report: The promising application of dynamic functional connectivity analysis on an individual with failed back surgery syndrome

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