The influence of non-pharmacological methods in osteoporosis treatment

Kujawska, Agnieszka; Gajos, Małgorzata; Topka, Weronika; Szmelcer, Beniamin; Bieniek, Daria; Modlińska, Aleksandra; Kożuchowski, Marcin; Perkowski, Radosław; Androsiuk-Perkowska, Joanna; Ziółkowska, Sylwia

doi:10.5281/zenodo.3386710

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“…The process of bone remodelling is controlled by many factors, including gender, somatic indices (body mass, ratio of muscle mass to lean body mass, body height, BMI –body mass index), diet ( e.g. protein and calcium supply), medications, stimulants, diseases or physical activity ( Sinaki, 2010 ; Andreoli et al, 2012 ; Kujawska et al, 2019 ).…”

Section: Introductionmentioning

confidence: 99%

Changes in the concentration of bone turnover markers in men after maximum intensity exercise

Bagińska,

Tota,

Morawska-Tota

et al. 2024

PeerJ

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Background Physical activity is an important factor in modelling the remodelling and metabolism of bone tissue. The aim of the study was to evaluate the changes in indices demonstrating bone turnover in men under the influence of maximum-intensity exercise. Methods The study involved 33 men aged 20–25, divided into two groups: experimental (n = 15) and control (n = 18). People training medium- and long-distance running were assigned to the experimental group, and non-training individuals to the control. Selected somatic, physiological and biochemical indices were measured. The level of aerobic fitness was determined using a progressively increasing graded test (treadmill test for subjective fatigue). Blood samples for determinations were taken before the test and 60 minutes after its completion. The concentration of selected bone turnover markers was assessed: bone fraction of alkaline phosphatase (b-ALP), osteoclacin (OC), N-terminal cross-linked telopeptide of the alpha chain of type I collagen (NTx1), N-terminal propeptide of type I progolagen (PINP), osteoprotegerin (OPG). In addition, the concentration of 25(OH)D3 prior to the stress test was determined. Additionally, pre and post exercise, the concentration of lactates in the capillary blood was determined. Results When comparing the two groups, significant statistical differences were found for the mean level of: 25(OH)D3 (p = 0.025), b-ALP (p < 0.001), OC (p = 0.004) and PINP (p = 0.029) prior to the test. On the other hand, within individual groups, between the values pre and post the stress test, there were statistically significant differences for the average level of: b-ALP (p < 0.001), NTx1 (p < 0.001), OPG (p = 0.001) and PINP (p = 0.002). Conclusion A single-session maximum physical effort can become an effective tool to initiate positive changes in bone turnover markers.

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Section: Introductionmentioning

confidence: 99%