The influence of nutritional factors on lead absorption

Barltrop, D.; Khoo, Hock Eng

doi:10.1136/pgmj.51.601.795

Cited by 138 publications

(69 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Previous human epidemiologic studies and experimental animal studies support this finding (Barltrop and Khoo 1975;Bell and Spickett 1983;DeLuca et al 1982;Lucas et al 1996;Mahaffey 1995). A possible mechanism by which dietary fat increases lead absorption involves the stimulation of bile secretion into the gastrointestinal tract by fat (Bell and Spickett 1983;Hilburn et al 1980;Lucas et al 1996).…”

Section: Discussionsupporting

confidence: 69%

“…These patterns persisted for both males and females as well as for younger children (< 12 months of age) and for older children (12 months of age or older; data not shown for age). To our knowledge, there have been no other human studies investigating whether caloric intake modifies the association between dust lead exposure and blood lead; however, this modification is supported by data from animal studies (Barltrop and Khoo 1975;Bell and Spickett 1983;DeLuca et al 1982;Kello and Kostial 1973;Nzelibe et al 1986). In addition, findings from human studies have been reported for the association between caloric intake and blood lead.…”

Section: Discussionmentioning

confidence: 80%

“…Few of these studies, however, have adjusted adequately for differences in lead exposure. Furthermore, to our knowledge, the question of whether nutrient intake modifies the association between blood lead and lead exposure in children has not been examined, although animal studies have shown a stronger association between blood lead and lead exposure for animals on high fat or high calorie diets compared with animals on low fat or low calorie diets (Barltrop and Khoo 1975;Bell and Spickett 1983;DeLuca et al 1982;Kello and Kostial 1973;Nzelibe et al 1986).…”

Section: Influence Of Nutrient Intake On Blood Lead Levels Of Young Cmentioning

confidence: 99%

See 2 more Smart Citations

Influence of nutrient intake on blood lead levels of young children at risk for lead poisoning.

Gallicchio

Scherer

Sexton

2002

Environ Health Perspect

View full text Add to dashboard Cite

Although removal of lead paint hazards from at-risk houses remains the primary means of preventing elevated blood lead among young children, reduction of risk through nutritional factors has also been of interest. In this study we evaluated the effect of nutrient intake on blood lead levels by analyzing whether the intakes of certain dietary components a) were associated with blood lead levels independent of lead exposure or b) modified the effect of lead exposure on blood lead. Subjects were 205 children from low-income families who were approximately 1 year of age and living in old, urban houses. The data collected for each child included blood lead level, nutritional status, and amount of lead exposure, which was assessed from samples of household dust. Multiple linear regression analyses showed a statistically significant positive association between lead exposure and blood lead. Statistically significant positive associations were found between blood lead and total fat as well as blood lead and saturated fat, independent of lead exposure and age of the child. Regression modeling and stratified analysis showed that mean blood lead increased with increasing lead exposure as well as with increasing caloric intake, suggesting that caloric intake modifies the association between lead exposure and blood lead. The findings from this study, if replicated in other studies, support a dietary intervention to reduce the amount of total calories, total fat, and saturated fat among children 1 year of age at risk for lead exposure, while maintaining adequate intake of these dietary components. Our results also reinforce recommendations that removal of lead paint hazards from at-risk houses should be the primary means of preventing lead exposure.

show abstract

Section: Discussionsupporting

confidence: 69%

Section: Discussionmentioning

confidence: 80%

Section: Influence Of Nutrient Intake On Blood Lead Levels Of Young Cmentioning

confidence: 99%

See 1 more Smart Citation

Influence of nutrient intake on blood lead levels of young children at risk for lead poisoning.

Gallicchio

Scherer

Sexton

2002

Environ Health Perspect

View full text Add to dashboard Cite

show abstract

“…Vários estudos experimentais investigaram o papel do estado nutricional na absorção e toxidez do chumbo 2,10,18 , partindo de clássicas observações clínicas que revelaram que crianças intoxicadas pelo chumbo eram geralmente desnutridas 8 . Existem poucos estudos relacionando a absorção de cádmio e desnutrição em crianças 3,10 .…”

Section: Introductionunclassified

Chumbo e cádmio no sangue e estado nutricional de crianças, Bahia, Brasil

et al. 1987

View full text Add to dashboard Cite

Num estudo de prevalência foi estudada a relação entre níveis de chumbo (PbS) e de cádmio no sangue (CdS) e o estado nutricional de crianças de 1 a 9 anos de idade, residentes a menos de 900 metros de uma fundição primária de chumbo, situada em Santo Amaro da Purificação, Bahia, Brasil. Em 555 crianças o nível médio (média ± s) de PbS foi de 2,84 ±1,20 µmol/1. Em 396 crianças, o nível médio de CdS (geométrico) foi de 0,087 µmol/1, com desvio padrão de 2,5. Os níveis de PbS e de CdS estavam extremamente elevados, mas não variaram significantemente entre subgrupos de crianças de diferentes estados nutricionais. Análises de regressão múltipla não mostraram associações estatisticamente significantes entre os níveis de PbS ou logCdS 1 malnutrição, medida através da relação peso/altura, mantidos constantes os efeitos de idade, sexo, grupo racial, hábito de geofagia, distância do domicílio da criança à fundição, ser filho de trabalhador da fundição, renda familiar, balanço de ferro do organismo e infestação ancilostomótica severa. A distância do domicílio da criança à fundição foi a variável que se mostrou mais fortemente associada à variação dos níveis de PbS ou de logCdS. O peso ou a altura de crianças com baixos níveis de chumbo no sangue (iguais ou inferiores a 1,68 µmol/1) não estavam significantemente associados com os níveis de PbS, mas mostraram elevada correlação com a idade dos indivíduos.

show abstract

“…Adults absorb roughly 10% of the total amount of lead ingested in the diet (Barltrop and Khoo, 1975;Heard and Chamberlain, 1982), although other studies suggest that absorption may be as high as 15-20% (Duggan, 1983). On the other hand, in infants less than 2 years old, 42% of dietary lead was absorbed with intakes =5 Jlg Pb/kg bodyweight (bw) (Ziegler et al, 1978).…”

Section: Introductionmentioning

confidence: 99%