The influence of obesity on blood mercury levels for U.S. non-pregnant adults and children: NHANES 2007–2010

Rothenberg, Sarah E.; Korrick, Susan A.; Fayad, Raja

doi:10.1016/j.envres.2015.01.018

Cited by 54 publications

(34 citation statements)

References 40 publications

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“…In addition, blood mercury has been used in epidemiologic studies as a marker for mercury exposure in the general population [1324]. The geometric mean of the blood mercury concentration in this study was 3.42 µg/L.…”

Section: Discussionmentioning

confidence: 67%

Association between Blood Mercury Level and Visceral Adiposity in Adults

Park

et al. 2017

Diabetes Metab J

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BackgroundFew studies have examined the association between mercury exposure and obesity. The aim of this study is to investigate the association between blood mercury concentrations and indices of obesity in adults.MethodsA total of 200 healthy subjects, aged 30 to 64 years, who had no history of cardiovascular or malignant disease, were examined. Anthropometric and various biochemical profiles were measured. Visceral adipose tissue (VAT) was measured using dual-energy X-ray absorptiometry (DXA).ResultsAll subjects were divided into three groups according to blood mercury concentrations. Compared with the subjects in the lowest tertile of mercury, those in the highest tertile were more likely to be male; were current alcohol drinkers and smokers; had a higher body mass index (BMI), waist circumference (WC), and VAT; had higher levels of blood pressure, fasting glucose, and insulin resistance; and consumed more fish. The blood mercury concentration was significantly associated with anthropometric parameters, showing relationships with BMI, WC, and VAT. After adjusting for multiple risk factors, the odds ratios (ORs) for high mercury concentration was significantly higher in the highest VAT tertile than in the lowest VAT tertile (OR, 2.66; 95% confidence interval, 1.05 to 6.62; P<0.05).ConclusionThe blood mercury concentration was significantly associated with VAT in healthy adults. Further studies are warranted to confirm our findings.

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Section: Discussionmentioning

confidence: 67%

Association between Blood Mercury Level and Visceral Adiposity in Adults

Park

et al. 2017

Diabetes Metab J

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“… 7) There were a few studies reported a negative associations between mercury concentrations and BMI. 9) …”

Section: Discussionmentioning

confidence: 99%

“…Moreover, the number of studies conducted on the pediatric population, in this context, is limited. 8 9) …”

Section: Introductionmentioning

confidence: 99%

The association of total blood mercury levels and overweight among Korean adolescents: analysis of the Korean National Health and Nutrition Examination Survey (KNHANES) 2010–2013

et al. 2018

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PurposeObesity has been associated with higher total blood mercury levels, based on animal studies; however, studies that focus on children and adolescents are lacking. We aimed to assess the association between total blood mercury levels and the incidence of overweight and abdominal obesity in Korean adolescents.MethodsThe study population comprised 1,567 adolescents (793 boys and 774 girls; aged 10–19 years), who participated in the Korea National Health and Nutrition Examination Survey 2010–2013. We analyzed total blood mercury levels according to obesity status in all participants.ResultsThe geometric mean of total blood mercury levels was 1.93 µg/L. Participants with overweight (2.20 µg/L) and obesity (2.17 µg/L) had higher levels than those with normal weight (1.86 µg/L, P<0.0001). The prevalence of overweight significantly increased with elevation of the total blood mercury quartile in both sexes. Increased incidence of abdominal obesity corresponding to increased total blood mercury level was observed in boys. After adjusting for covariates, those in the highest total blood mercury quartile were found to be at higher risk of overweight/obesity than those in the lowest quartile in both sexes (odds ratio [95% confidence interval]: boys, 3.27 [1.66–6.41]; girls, 1.90 [1.03–3.49]). The association between total blood mercury quartile and abdominal obesity was significant after controlling for covariates in boys (2.35 [1.05–5.24]).ConclusionOur results suggest an association between total blood mercury levels and overweight in Korean adolescents.

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“…Dietary MeHg intake was low for most mothers, and therefore results were not necessarily applicable to populations ingesting more fish. Most mothers were overweight or obese, which possibly affected MeHg metabolism (Rothenberg et al 2015). However, aside from one genus ( Blautia ), there were no significant associations between obesity and gut microbiota, and there were no genera significant at the FDR of 20%.…”

Section: Discussionmentioning

confidence: 99%

The role of gut microbiota in fetal methylmercury exposure: Insights from a pilot study

et al. 2016

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PURPOSE The mechanisms by which gut microbiota contribute to methylmercury metabolism remain unclear. Among a cohort of pregnant mothers, the objectives of our pilot study were to determine 1) associations between gut microbiota and mercury concentrations in biomarkers (stool, hair and cord blood) and 2) the contributions of gut microbial mercury methylation/demethylation to stool methylmercury. METHODS Pregnant women (36–39 weeks gestation, n=17) donated hair and stool specimens, and cord blood was collected for a subset (n=7). The diversity of gut microbiota was determined using 16S rRNA gene profiling (n=17). For 6 stool samples with highest/lowest methylmercury concentrations, metagenomic whole genome shotgun sequencing was employed to search for the mercury methylation gene (hgcA), and two mer operon genes involved in methylmercury detoxification (merA and merB). RESULTS Seventeen bacterial genera were significantly correlated (increasing or decreasing) with stool methylmercury, stool inorganic mercury, or hair total mercury; however, aside from one genus, there was no overlap between biomarkers. There were no definitive matches for hgcA or merB, while merA was detected at low concentrations in all six samples. MAJOR CONCLUSIONS Proportional differences in stool methylmercury were not likely attributed to gut microbiota through methylation/demethylation. Gut microbiota potentially altered methylmercury metabolism using indirect pathways.

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The influence of obesity on blood mercury levels for U.S. non-pregnant adults and children: NHANES 2007–2010

Cited by 54 publications

References 40 publications

Association between Blood Mercury Level and Visceral Adiposity in Adults

Association between Blood Mercury Level and Visceral Adiposity in Adults

The association of total blood mercury levels and overweight among Korean adolescents: analysis of the Korean National Health and Nutrition Examination Survey (KNHANES) 2010–2013

The role of gut microbiota in fetal methylmercury exposure: Insights from a pilot study

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