The Influence of Oestrogens on the Wellbeing and Mental Performance in Climacteric and Postmenopausal Women

Fedor-Freybergh, Peter G.

doi:10.3109/00016347709156459

Cited by 93 publications

(86 citation statements)

References 46 publications

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“…These studies have been reasonably consistent in observing a positive association between estrogen therapy and recent verbal memory 16,20,21,23,25,26,31 and reasoning, 19,20,28,31 whereas other cognitive domains have either shown no association or mixed results. [16][17][18][19][20][21][22][23][24][27][28][29][30]32 The strongest support for a relation between estrogen and brain function comes from studies in basic neurobiology.…”

Section: Arch Internmentioning

confidence: 59%

Postmenopausal Estrogen and Estrogen-Progestin Use and 2-Year Rate of Cognitive Change in a Cohort of Older Japanese American Women

Rice¹,

Graves²,

McCurry³

et al. 2000

Arch Intern Med

140

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Section: Arch Internmentioning

confidence: 59%

Postmenopausal Estrogen and Estrogen-Progestin Use and 2-Year Rate of Cognitive Change in a Cohort of Older Japanese American Women

Rice¹,

Graves²,

McCurry³

et al. 2000

Arch Intern Med

140

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“…The study involved premenopausal women (based on regular menstrual cycles and follicle-stimulating hormone less than 20 mIU/mL) with the following characteristics: 30 to 45 years of age, a body mass index between 18 and 35 kg/m 2 , diminished sexuality (Sabbatsberg Sexual Self-Rating Scale 15 score less than 42 16 ), no evidence of severe clinical depression on the Beck Depression Inventory (score less than 28), 17 and early morning serum total testosterone of less than 2.2 nmol/L. All participants were in general good health based on history and physical examination and had a normal cervical smear within the past year.…”

Section: Study Participantsmentioning

confidence: 99%

“…17 Possible scores ranged from 0 (minimal depression) to 63 (severe depression). The Sabbatsberg Sexual Self-Rating Scale 15 is a multiple-choice questionnaire containing seven aspects of sexuality (sexual interest, sexual activity, satisfaction of sexual life, experience of sexual pleasure, sexual fantasy, orgasm capacity, and sexual relevancy), which has been validated in premenopausal women. 16 Possible composite scores range from 0 (low sexuality) to 84 (high sexuality).…”

mentioning

confidence: 99%

Transdermal testosterone therapy improves well-being, mood, and sexual function in premenopausal women

et al. 2003

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Objective: Circulating testosterone in women declines during the late reproductive years such that otherwise healthy women in their 40s have approximately half the testosterone level as women in their 20s. Despite this, research showing the benefits of androgen replacement has been limited to the postmenopausal years. In view of the known premenopausal physiological decline in testosterone, we have evaluated the efficacy of transdermal testosterone therapy on mood, well-being, and sexual function in eugonadal, premenopausal women presenting with low libido.Design: Premenopausal women with low libido participated in a randomized, placebocontrolled, crossover, efficacy study of testosterone cream (10 mg/day) with two double-blind, 12-week, treatment periods separated by a single-blind, 4-week, washout period.Results: Thirty-four women completed the study per protocol, with 31 women (mean age 39.7 ± 4.2 years; serum testosterone 1.07 + 0.50 nmol/L) providing complete data. Testosterone therapy resulted in statistically significant improvements in the composite scores of the Psychological General Well-Being Index [+12.9 (95% CI, +4.6 to +21.2), P = 0.003] and the Sabbatsberg Sexual Self-Rating Scale [+15.7 (95% CI, +6.5 to +25.0), P = 0.001] compared with placebo. A mean decrease in the Beck Depression Inventory score approached significance [−2.8 (95% CI, −5.7 to +0.1), P = 0.06]. Mean total testosterone levels during treatment were at the high end of the normal range, and estradiol was unchanged. No adverse effects were reported.Conclusions: Testosterone therapy improves well-being, mood, and sexual function in premenopausal women with low libido and low testosterone. As a substantial number of women experience diminished sexual interest and well-being during their late reproductive years, further research is warranted to evaluate the benefits and safety of longer-term intervention.

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“…Apesar de toda a imprecisão relacionada tanto à definição quanto ao diagnóstico dos traços de personalidade, pudemos observar uma semelhança dos nossos achados com a literatura consultada (7,(9)(10)(11)(18)(19)(20)(21)(22). A elevação de traços de personalidade alterados na população de mulheres com síndrome do climatério que procuram atendimento em uma clínica especializada foi semelhante à encontrada por outros autores (11,18,20).…”

Section: Discussionunclassified

“…A elevação de traços de personalidade alterados na população de mulheres com síndrome do climatério que procuram atendimento em uma clínica especializada foi semelhante à encontrada por outros autores (11,18,20). Esse aumento era característico em relação As informações obtidas com o nosso estudo não podem ser generalizadas para as mulheres no climatério pois a nossa amostra não é representativa da população geral.…”

Section: Discussionunclassified

Associação entre traços de personalidade e sintomas depressivos em mulheres com síndrome do climatério

Appolinário¹,

Meirelles²,

Coutinho³

et al. 2001

Arq Bras Endocrinol Metab

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RESUMOO climatério é reconhecido como um período da vida da mulher associado a um aumento de sintomas psiquiátricos. O objetivo deste estudo foi o de investigar as possíveis relações entre alguns traços de personalidade hipocondríacos no aparecimento de determinados sintomas depressivos nessa população. Cento e dezoito (118) ABSTRACTThe climateric is known as a period of the woman's life cycle full of emotional shifts and psychopathology. The aim of this study was to investigate the relationship between a hypochondriac personality pattern and the occurrence of climateric syndrome depressive symptoms. One hundred and eighteen (118) women seeking medical care for climateric symptoms were evaluated; 43 post-menopausal women (45-55 years) with somatic and psychological symptoms of the climateric syndrome were selected. Somatic symptoms were evaluated by the menopausal index (MI). Psychiatric symptoms were evaluated by the Hamilton depression scale (HAM-D) and the Minnesota multiphasic personality inventory (MMPI). The patients were divided into two groups according to the severity of the depressive symptoms. Patients with HAM-D scores Ž 15 were assigned to group I and those with HAM-D scores < 15 were allocated to group II. Comparing MMPI evaluation of the two groups we found no significant statistical difference of "neurotic triad" personality traits characteristic of hypochondriacal behavior. Thus, the occurrence of depressive symptoms in the climateric syndrome in this population could not be associated with the presence of hypochondriacal traits. (Arq Bras Endocrinol Metab 2001;45/4:383-389)

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The Influence of Oestrogens on the Wellbeing and Mental Performance in Climacteric and Postmenopausal Women

Cited by 93 publications

References 46 publications

Postmenopausal Estrogen and Estrogen-Progestin Use and 2-Year Rate of Cognitive Change in a Cohort of Older Japanese American Women

Postmenopausal Estrogen and Estrogen-Progestin Use and 2-Year Rate of Cognitive Change in a Cohort of Older Japanese American Women

Transdermal testosterone therapy improves well-being, mood, and sexual function in premenopausal women

Associação entre traços de personalidade e sintomas depressivos em mulheres com síndrome do climatério

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