The Influence of Omeprazole on the Dissolution Processes of pH-Dependent Magnetic Tablets Assessed by Pharmacomagnetography

Soares, Gláucia Resende; Pires, Deivid W.; Pinto, Leonardo A.; Rodrigues, Gustavo S.; Próspero, André Gonçalves; Biasotti, Gabriel G. A.; Bittencourt, Gabriela Nogueira; Stoppa, Erick G.; Corá, Luciana Aparecida; Oliveira, Ricardo Brandt de; Miranda, José Ricardo de Arruda

doi:10.3390/pharmaceutics13081274

Cited by 7 publications

(7 citation statements)

References 49 publications

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“…Our group has extensive knowledge in drug delivery studies and gastroenterology assessments in animals and humans using the ACB methodology, focusing on assessing solid dosage forms in the through images [ 17 , 35 – 38 ]. Our group also has studied the effects of pathologies, surgeries, and disturbed physiological states of the gastrointestinal transit in rats through images [ 39 – 43 ].…”

Section: Discussionmentioning

confidence: 99%

Quantitative imaging of magnetic nanoparticles in an unshielded environment using a large AC susceptibility array

et al. 2022

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Background Non-invasive magnetic imaging techniques are necessary to assist magnetic nanoparticles in biomedical applications, mainly detecting their distribution inside the body. In Alternating Current Biosusceptometry (ACB), the magnetic nanoparticle's magnetization response under an oscillating magnetic field, which is applied through an excitation coil, is detected with a balanced detection coil system. Results We built a Multi-Channel ACB system (MC-ACB) containing nineteen pick-up coils and obtained 2D quantitative images of magnetic nanoparticle distributions by solving an inverse problem. We reconstructed the magnetic nanoparticles spatial distributions in a field of view of 14 × 14 cm2 with a spatial resolution of 2.0 cm and sensitivity in the milligram scale. A correlation coefficient between quantitative reconstructed and nominal magnetic nanoparticle distributions above 0.6 was found for all measurements. Conclusion Besides other interesting features such as sufficient large field of view dimension for mice and rat studies, portability, and the ability to assess the quantitative magnetic nanoparticles distributions in real-time, the MC-ACB system is a promising tool for quantitative imaging of magnetic nanoparticles distributions in real-time, offering an affordable setup for easy access in clinical or laboratory environments.

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Section: Discussionmentioning

confidence: 99%

Quantitative imaging of magnetic nanoparticles in an unshielded environment using a large AC susceptibility array

et al. 2022

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“…Floating lag time (FLT), gastric retention time (GRT), and orocaecal transit time (OCTT) were determined by scanning gastric projections in different regions [ 58 , 60 ]. By collecting data on magnetic field deformation intensity over time and registering it in a data matrix, images corresponding to the tablet’s position at specific times can be obtained.…”

Section: Methodsmentioning

confidence: 99%

“…At the end of the procedure, volunteers received a standard lunch (Perdigão ® lasagna with Del Valle ® orange juice, Perdigão, Brazil). Floating lag time (FLT), gastric retention time (GRT), and orocaecal transit time (OCTT) were determined by scanning gastric projections in different regions [58,60]. By Floating lag time (FLT), gastric retention time (GRT), and orocaecal transit time (OCTT) were determined by scanning gastric projections in different regions [58,60].…”

Section: In Vivo Study Protocolmentioning

confidence: 99%

“…This methodology involves incorporating magnetic elements into pharmaceutical formulations, such as tablets or capsules, allowing real-time transit and disintegration monitoring using external magnetic sensors with imaging techniques. Thus, pharmacomagnetography is valuable for simultaneously studying drug distribution, gastrointestinal motility, and drug absorption kinetics [ 58 , 59 , 60 ].…”

Section: Introductionmentioning

confidence: 99%

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In Vitro and In Vivo Evaluation of Magnetic Floating Dosage Form by Alternating Current Biosusceptometry

Rodrigues,

Barboza,

Buranello

et al. 2024

Pharmaceutics

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Floating controlled systems seek to extend the gastric retention time (GRT) of solid pharmaceutical forms by sustaining buoyancy in the stomach without affecting gastric emptying rates. This investigation aimed to evaluate a magnetic floating drug delivery system (MFDDS) under diverse physiological conditions (pressure and viscosity) using an Alternating Current Biosusceptometry (ACB) system by conducting assessments in vitro and in vivo. For in vitro experiments, MFDDSs were placed under different pressures (760, 910, and 1060 mmHg) and viscosities (1, 50, 120, and 320 mPa·s) for evaluation of floating lag time (FLT). For in vivo experiments, eight healthy volunteers participated in two phases (fasting and fed) for gastric parameters (GRT, FLT, and OCTT—orocaecal transit time) assessment, employing the ACB system. The results indicated that pressure, viscosity, and FLT were directly proportional in the in vitro assay; in addition, increases in the OCTT (fasting = 241.9 ± 18.7; fed = 300 ± 46.4), GRT (fasting = 139.4 ± 25.3; fed = 190.2 ± 47.7), and FLT (fasting = 73.1 ± 16.9; fed = 107.5 ± 29.8) were detected in vivo. Our study emphasizes that the ACB system is a valuable technique, and it is capable of tracking and imaging MFDDS in in vitro and in vivo experiments.

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“…Moreover, previous studies showed the potential of the ACB system to perform quantitative ex vivo biodistribution studies of MNPs employing organs and cells samples with both position and volume fixed (1D quantitative signals) [15,16,19,20]. Therefore, it is desired to both assess the ACB system's abilities for imaging and quantitative analysis, and to increase its spatial resolution, to perform MNP quantitative imaging of tablets, organs, and anatomical structures, which can be used in pharmaceutical and physiological studies [12,16,17,21,22]. Such an achievement can create new possibilities of ACB applications in biomedical studies involving MNPs.…”

Section: Introductionmentioning

confidence: 99%

2D Quantitative Imaging of Magnetic Nanoparticles by an AC Biosusceptometry Based Scanning Approach and Inverse Problem

Biasotti

Próspero

Alvarez

et al. 2021

Sensors

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The use of magnetic nanoparticles (MNPs) in biomedical applications requires the quantitative knowledge of their quantitative distribution within the body. AC Biosusceptometry (ACB) is a biomagnetic technique recently employed to detect MNPs in vivo by measuring the MNPs response when exposed to an alternate magnetic field. The ACB technique presents some interesting characteristics: non-invasiveness, low operational cost, high portability, and no need for magnetic shielding. ACB conventional methods until now provided only qualitative information about the MNPs’ mapping in small animals. We present a theoretical model and experimentally demonstrate the feasibility of ACB reconstructing 2D quantitative images of MNPs’ distributions. We employed an ACB single-channel scanning approach, measuring at 361 sensor positions, to reconstruct MNPs’ spatial distributions. For this, we established a discrete forward problem and solved the ACB system’s inverse problem. Thus, we were able to determine the positions and quantities of MNPs in a field of view of 5×5×1 cm3 with good precision and accuracy. The results show the ACB system’s capabilities to reconstruct the quantitative spatial distribution of MNPs with a spatial resolution better than 1 cm, and a sensitivity of 1.17 mg of MNPs fixed in gypsum. These results show the system’s potential for biomedical application of MNPs in several studies, for example, electrochemical-functionalized MNPs for cancer cell targeting, quantitative sensing, and possibly in vivo imaging.

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The Influence of Omeprazole on the Dissolution Processes of pH-Dependent Magnetic Tablets Assessed by Pharmacomagnetography

Cited by 7 publications

References 49 publications

Quantitative imaging of magnetic nanoparticles in an unshielded environment using a large AC susceptibility array

Quantitative imaging of magnetic nanoparticles in an unshielded environment using a large AC susceptibility array

In Vitro and In Vivo Evaluation of Magnetic Floating Dosage Form by Alternating Current Biosusceptometry

2D Quantitative Imaging of Magnetic Nanoparticles by an AC Biosusceptometry Based Scanning Approach and Inverse Problem

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