The influence of on-pump and off-pump coronary artery bypass grafting on hemorheological parameters

Papp, Judit; Tóth, András; Sandor, Barbara; Kiss, Rudolf; Rábai, Miklós; Kenyeres, Péter; Juricskay, I.; Késmárky, Gábor; Szabados, S.; Tóth, Kálmán

doi:10.3233/ch-2011-1484

Cited by 17 publications

(14 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The changes in aggregation behavior we observed for the RBCs of patients undergoing EC-assisted surgery were observed for a relatively short period of time (Figure 3), but others have described much longer lasting effects. 4 The changes in cell volume, osmotic fragility, and deformability indicate that changes in membrane organization that affect mechanisms involved in the transport of water and/or ions occur mainly in the first hours of circulation in an extracorporeal circuit. 7 Later changes, especially the observed decrease in maximal deformability (Figure 3), are mainly due to a decrease in the surface area/volume ratio.…”

Section: Discussionmentioning

confidence: 99%

The impact of circulation in a heart–lung machine on function and survival characteristics of red blood cells

et al. 2020

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

The impact of circulation in a heart–lung machine on function and survival characteristics of red blood cells

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Earlier studies show that changes in blood viscosity occurs immediately after induction of anesthesia, immediately after surgery, 1 and 2 days after surgery and normalizes between 3 and 4 days post-cardiothoracic surgery [ 12 ]. For this reason blood samples were collected at four time points: preoperatively, directly after the induction of anesthesia (T -1 ), within one hour of ICU admission (T 0 ), day one (T 24 ) and three days (T 72 ) after cardiothoracic surgery.…”

Section: Methodsmentioning

confidence: 99%

“…Cerebral blood flow is strongly related to whole blood viscosity (WBV) [ 11 ]. Changes in blood viscosity occur post-cardiothoracic surgery [ 12 ]. As such, changes in blood viscosity could relate to occurrence of postoperative delirium and this could represent an important interventional target to prevent or treat delirium.…”

Section: Introductionmentioning

confidence: 99%

Absence of association between whole blood viscosity and delirium after cardiac surgery: a case-controlled study

CheheiliSobbi

Boogaard

Slooter

et al. 2016

J Cardiothorac Surg

View full text Add to dashboard Cite

BackgroundDelirium after cardiothoracic surgery is common and associated with impaired outcomes. Although several mechanisms have been proposed (including changes in cerebral perfusion), the pathophysiology of postoperative delirium remains unclear. Blood viscosity is related to cerebral perfusion and thereby might contribute to the development of delirium after cardiothoracic surgery. The aim of this study was to investigate whether whole blood viscosity differs between cardiothoracic surgery patients with and without delirium.MethodsIn this observational study postoperative whole blood viscosity of patients that developed delirium (cases) were compared with non-delirious cardiothoracic surgery patients (controls). Cases were matched with the controls, yielding a 1:4 case–control study. Serial hematocrit, fibrinogen, and whole blood viscosity were determined pre-operatively and at each postoperative day. Delirium was assessed using the validated Confusion Assessment Method for the Intensive Care Unit or Delirium Screening Observation scale.ResultsIn total 80 cardiothoracic surgery patients were screened of whom 12 delirious and 48 matched non-delirious patients were included. No significant difference was found between both groups in fibrinogen (p = 0.36), hematocrit (p = 0.23) and the area under curve of the whole blood viscosity between shear rates 0.02 and 50 s-1 (p = 0.80) or between shear rates 0.02 and 5 s-1 (p = 0.78).ConclusionIn this case control study in cardiothoracic surgery patients changes in whole blood viscosity were not associated with the development of delirium.

show abstract

“…OPCAB has the advantages of being associated with preserved hematocrit levels and pulsatile flow generated by the beating heart, contributing to preservation and maintenance of microcirculatory perfusion (Papp et al 2011). In addition, extracorporeal contact activation is absent.…”

Section: Introductionmentioning

confidence: 99%

Comparing perioperative magnesium sulphate, lidocaine, and their combination in preventing ventricular arrhythmia in off-pump coronary artery bypass grafting

Sarhan

Mahmoud

Seddiq

2019

Ain-Shams J Anesthesiol

View full text Add to dashboard Cite

Background: Techniques of coronary artery bypass grafting (CABG) have developed rapidly over the last decades. However, dysrhythmia is a common feature during off pump CABG. The aim of this work was to study effect of perioperative magnesium sulphate infusion on the incidence of cardiac arrhythmia in off-pump CABG: and comparing such effects to lidocaine alone or combined to magnesium. Methodology: Ninety patients undergoing elective coronary artery bypass grafting surgery were randomly divided into three equal groups: magnesium group received magnesium over 12 h prior to off-pump surgery and over 30 min intraoperatively; lidocaine group were given an intravenous bolus injection of lidocaine followed by a continuous infusion; and combination group received half the doses of magnesium and lidocaine prescribed for the other two groups. The patients' perioperative hemodynamic data (heart rate and mean arterial pressure) and the occurrence of intraoperative and postoperative arrhythmia were recorded. Results: There was statistically significant difference between study groups as regards mean intraoperative heart rate and intraoperative mean arterial pressure. In addition, the need for intraoperative beta-blockers was significantly higher in lidocaine group; there was no need for intraoperative beta-blockers for combination group. Also, the need for perioperative aortic balloon pump was significantly higher in lidocaine group (20.0%), followed by 6.7% in magnesium group, and none in combination group. The percentage of ventricular tachycardia was significantly higher in lidocaine group (16.7%), followed by magnesium group (3.3%) and none in combination group. Conclusion: Results of the present study revealed that combination of both perioperative magnesium and lidocaine when compared to each of both drugs separately has a better effect in controlling hemodynamics (heart rate and mean arterial blood pressure intraoperatively), less ventricular tachycardia, and reduction in the need for beta blockers and aortic balloon pump perioperatively. In addition, magnesium was superior to lidocaine, although both are effective.

show abstract

The influence of on-pump and off-pump coronary artery bypass grafting on hemorheological parameters

Cited by 17 publications

References 21 publications

The impact of circulation in a heart–lung machine on function and survival characteristics of red blood cells

The impact of circulation in a heart–lung machine on function and survival characteristics of red blood cells

Absence of association between whole blood viscosity and delirium after cardiac surgery: a case-controlled study

Comparing perioperative magnesium sulphate, lidocaine, and their combination in preventing ventricular arrhythmia in off-pump coronary artery bypass grafting

Contact Info

Product

Resources

About