“…Some reported reduced mortality and some did not [1,14,16,26,38,41]. Some showed an improved functional status, while others did not [1,10,32,35]. That is why other therapy goals have been proposed [32], e.g., more patientcentered goals like informing the participants or improvement of the family relationship or the use of preventive measures and influencing the health-related behavior [8,13,23,44].…”