The influence of oxytocin on eating behaviours and stress in women with bulimia nervosa and binge eating disorder

Leslie, Monica; Leppänen, Jenni; Paloyelis, Yannis; Treasure, Janet

doi:10.1016/j.mce.2018.12.014

Cited by 22 publications

(12 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…That is, one might reasonably hypothesise that reduced hedonic food consumption would be associated with less attentional and motivational orientation to food stimuli. However, previous studies finding a suppression of hedonic eating reported this effect in male participant samples, 20,24,36 although no effect of oxytocin on feeding was found in the current sample of female participants 31 . An accumulating range of studies has found mixed effects of oxytocin on eating in women, both with and without eating disorders, 17,27 therefore suggesting that the inhibitory effect of oxytocin on hedonic eating and orienting to food stimuli may be sex‐specific in humans.…”

Section: Discussioncontrasting

confidence: 62%

“…Following the completion of the bogus taste test, the three bowls of food were brought to a separate room, out of sight of the participant, where a research assistant weighed the remaining food in each bowl and subtracted this amount from the initial weight of each type of food. The effect of oxytocin on the quantity of food eaten is reported elsewhere 31 …”

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

A pilot study investigating the influence of oxytocin on attentional bias to food images in women with bulimia nervosa or binge eating disorder

Leslie

Leppänen

Paloyelis

et al. 2020

J Neuroendocrinology

Self Cite

View full text Add to dashboard Cite

Background: Previous research has found that exogenous oxytocin administration has the potential to modulate attentional biases in women with anorexia nervosa.Recent work has indicated that attentional biases to food may reinforce the recurrent binge eating behaviour characterising bulimia nervosa and binge eating disorder.To date, however, no study has yet investigated the effect of oxytocin on attentional biases to palatable food in women with bulimia nervosa and binge eating disorder. Methods:The present study employed a single-session cross-over design to test the hypothesis that a divided dose of 64 IU of intranasal oxytocin, administered as one intranasal dose of 40 IU of oxytocin followed by a top-up of 24 IU of oxytocin 80 minutes later, vs placebo administration administered in the same dosing schedule would reduce attentional biases towards food images in a dot probe task. We hypothesised that oxytocin administration would reduce vigilance towards food to a greater degree in women with bulimia nervosa or binge eating disorder vs healthy comparison women. Twenty-five women with bulimia nervosa or binge eating disorder and 27 comparison women without history of an eating disorder were recruited to take part in the study. Results:In contrast to our hypothesis, there was no main effect of diagnosis on attentional bias to food (fixed effect = 5.70, P = 0.363), nor a significant interaction between diagnosis and drug condition (fixed effect =−14.80, P = 0.645). There was a main effect of drug condition, such that oxytocin increased vigilance towards food vs neutral images in the dot probe task (fixed effect = 10.42, P = 0.044). A correlation analysis revealed that this effect was moderated by attentional bias in the placebo condition, such that greater avoidance of food stimuli in the placebo condition was associated with a greater increase in vigilance induced by oxytocin. Conclusions:The findings of the present study add to a mixed body of literature investigating the therapeutic effects of oxytocin in women. Future research would benefit from dose-response studies investigating the optimal dose of oxytocin for

show abstract

Section: Discussioncontrasting

confidence: 62%

Section: Methodsmentioning

confidence: 99%

A pilot study investigating the influence of oxytocin on attentional bias to food images in women with bulimia nervosa or binge eating disorder

Leslie

Leppänen

Paloyelis

et al. 2020

J Neuroendocrinology

Self Cite

View full text Add to dashboard Cite

show abstract

“…We have recently shown that a divided dose of intranasal OT (64 IU) modulates risk-taking behaviour in women with BN/BED 45 and increases vigilance towards food, vs. neutral, images in a dot probe task in both women with and without BN/BED 46 . However, in the same cohort of women with BN/BED, we failed to find any effect of the same divided dose of intranasal OT (64 IU) on eating behaviour or stress response 47 . Apart from the lack of clarity regarding the effectiveness of intranasal OT to improve eating symptomatology in patients with BN/BED, it is also not clear which brain circuits intranasal OT targets in BN/BED patients.…”

Section: Introductioncontrasting

confidence: 55%

Investigating resting brain perfusion abnormalities and disease target-engagement by intranasal oxytocin in women with bulimia nervosa and binge-eating disorder and healthy controls

et al. 2020

Self Cite

View full text Add to dashboard Cite

Advances in the treatment of bulimia nervosa and binge-eating disorder (BN/BED) have been marred by our limited understanding of the underpinning neurobiology. Here we measured regional cerebral blood flow (rCBF) to map resting perfusion abnormalities in women with BN/BED compared with healthy controls and investigate whether intranasal oxytocin (OT), proposed as a potential treatment, can restore perfusion in disorder-related brain circuits. Twenty-four women with BN/BED and 23 healthy women participated in a randomized, double-blind, crossover, placebo-controlled study. We used arterial spin labelling MRI to measure rCBF and the effects of an acute dose of intranasal OT (40 IU) or placebo over 18-26 min post dosing, as we have previously shown robust OT-induced changes in resting rCBF in men in a similar time-window (15-36 min post dosing). We tested for effects of treatment, diagnosis and their interaction on extracted rCBF values in anatomical regions-of-interest previously implicated in BN/BED by other neuroimaging modalities, and conducted exploratory whole-brain analyses to investigate previously unidentified brain regions. We demonstrated that women with BN/BED presented increased resting rCBF in the medial prefrontal and orbitofrontal cortices, anterior cingulate gyrus, posterior insula and middle/inferior temporal gyri bilaterally. Hyperperfusion in these areas specifically correlated with eating symptoms severity in patients. Our data did not support a normalizing effect of intranasal OT on perfusion abnormalities in these patients, at least for the specific dose (40 IU) and post-dosing interval (18-26 min) examined. Our findings enhance our understanding of resting brain abnormalities in BN/BED and identify resting rCBF as a non-invasive potential biomarker for disease-related changes and treatment monitoring. They also highlight the need for a comprehensive investigation of intranasal OT pharmacodynamics in women before we can fully ascertain its therapeutic value in disorders affecting predominantly this gender, such as BN/BED.

show abstract

“…In addition to their classical roles in reproduction, stress and water balance, oxytocin and vasopressin have roles in energy homeostasis . Both central and peripheral oxytocin administration exert anorexigenic effects, increase energy expenditure and induce lipolysis . Peripheral administration of both oxytocin and vasopressin can induce the release of insulin from the pancreas and systemically administered oxytocin in humans (administered intranasally) has been reported to curb the meal‐related increase in plasma glucose, as well as to improve β‐cell responsivity and glucose tolerance in healthy men .…”

Section: Introductionmentioning

confidence: 99%

Peripheral insulin administration enhances the electrical activity of oxytocin and vasopressin neurones in vivo

Paiva

Leng

2020

J Neuroendocrinology

View full text Add to dashboard Cite

Oxytocin neurones are involved in the regulation of energy balance through diverse central and peripheral actions and, in rats, they are potently activated by gavage of sweet substances. Here, we test the hypothesis that this activation is mediated by the central actions of insulin. We show that, in urethane‐anaesthetised rats, oxytocin cells in the supraoptic nucleus show prolonged activation after i.v. injections of insulin, and that this response is greater in fasted rats than in non‐fasted rats. Vasopressin cells are also activated, although less consistently. We also show that this activation of oxytocin cells is independent of changes in plasma glucose concentration, and is completely blocked by central (i.c.v.) administration of an insulin receptor antagonist. Finally, we replicate the previously published finding that oxytocin cells are activated by gavage of sweetened condensed milk, and show that this response too is completely blocked by central administration of an insulin receptor antagonist. We conclude that the response of oxytocin cells to gavage of sweetened condensed milk is mediated by the central actions of insulin.

show abstract

The influence of oxytocin on eating behaviours and stress in women with bulimia nervosa and binge eating disorder

Cited by 22 publications

References 33 publications

A pilot study investigating the influence of oxytocin on attentional bias to food images in women with bulimia nervosa or binge eating disorder

A pilot study investigating the influence of oxytocin on attentional bias to food images in women with bulimia nervosa or binge eating disorder

Investigating resting brain perfusion abnormalities and disease target-engagement by intranasal oxytocin in women with bulimia nervosa and binge-eating disorder and healthy controls

Peripheral insulin administration enhances the electrical activity of oxytocin and vasopressin neurones in vivo

Contact Info

Product

Resources

About