The influence of papillary features on the risk of malignancy in thyroid nodules diagnosed as atypia of undetermined significance or follicular lesion of undetermined significance

Mashat, Abdullah; Hilzenrat, Roy; Masoudi, Hamid; Walker, Blair; Wiseman, Sam M.

doi:10.1016/j.amjsurg.2023.02.019

Cited by 1 publication

(2 citation statements)

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“…This individualized surgical management strategy should be considered in conjunction with thorough preoperative imaging and lymph node evaluation to guide surgical planning and patient counseling. 25,26 In addition to surgical management, close surveillance plays a critical role in the long-term care of young men with PTC. 27,28 Given their higher propensity for lymph node involvement, more frequent follow-up imaging, such as neck ultrasound, may be necessary to monitor for potential disease recurrence.…”

Section: Discussionmentioning

confidence: 99%

“…In the case of young men with PTC, a more systemic surgical approach, including lateral neck lymph node dissection, may be warranted to address the increased risk of lymph node metastasis. This individualized surgical management strategy should be considered in conjunction with thorough preoperative imaging and lymph node evaluation to guide surgical planning and patient counseling 25,26 …”

Section: Discussionmentioning

confidence: 99%

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Young and resilient: Unraveling papillary thyroid cancer outcomes in males under 40

Hood,

Zmijewski,

McLeod

et al. 2024

World j. surg.

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BackgroundWhile males present with more adverse clinicopathologic features in papillary thyroid carcinoma (PTC), younger age has previously been shown to be a favorable prognostic factor. We examined the combined effect of male sex and young age on PTC outcomes.MethodsWe conducted a retrospective analysis of a prospectively maintained database of thyroid cancer surgery patients (2000–2020) at a single quaternary care institution. We included papillary thyroid carcinoma cases and excluded those with prior cancer‐related thyroid surgery. We examined demographics, cancer stage, surgical outcomes, and complications by age and sex, analyzing groups below and above the age of 40 years.ResultsA total of 680 patients with PTC were included. Females constituted 68% (age ≥40 years: 44% and <40 years: 24%) and males 32% (≥40 years: 24% and <40 years: 8%). A significant difference (p < 0.001) of N1 disease distribution was found between the groups. N1a metastasis was greater in patients younger than 40 regardless of sex ((M < 40 (15%), F < 40 (15%), M ≥ 40 (12%), and F ≥ 40 (9%)). While, M < 40 had greater N1b metastasis (36%) than all other groups (M ≥ 40 (28%), F < 40 (22%), and F ≥ 40 (10%)). There was no significant difference in the distribution of T stages between groups. Groups showed no differences in 30‐day outcomes, recurrence at 1 year, reoperation, mortality, nerve injury, or hypocalcemia.ConclusionsYoung males with PTC face increased occurrence of nodal metastasis yet experience similar recurrence rates as their female and older counterparts. Subgroup analysis underscores the predictive role of sex and age in advanced PTC cases.

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