The influence of parasitism on the pharmacokinetics of moxidectin in lambs

Lespine, Anne; Sutra, J.F.; Dupuy, Jacques; Alvinerie, M.; Aumont, Gilles

doi:10.1007/s00436-004-1084-x

Cited by 32 publications

(23 citation statements)

References 25 publications

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“…These results are in agreement with our previous study, which demonstrated that parasitism induced significant changes in DRM disposition and availability, changes that are associated with a greater drug clearance, in comparison with the parasite-naive animals (Pérez et al 2007). Similarly, other studies have shown that the duration for moxidectin action may be reduced when the nutritional stress of parasitic disease affects body condition (Hennessy and Alvinerie 2002;Lespine et al 2004). …”

Section: Analytical Methodology Validationsupporting

confidence: 92%

“…As previously demonstrated (Pérez et al 2007), gastrointestinal parasitism induces significant changes in plasma disposition and DRM availability in subcutaneously treated lambs. Similar effects in sheep have been described for moxidectin (Lespine et al 2004) and ivermectin (Pérez et al 2006).…”

Section: Introductionsupporting

confidence: 59%

“…These changes may have a major impact on the plasma, tissue, and gastrointestinal disposition of anthelmintic drugs and consequently on their anthelmintic efficacy (Lespine et al 2004). As previously demonstrated (Pérez et al 2007), gastrointestinal parasitism induces significant changes in plasma disposition and DRM availability in subcutaneously treated lambs.…”

Section: Introductionmentioning

confidence: 91%

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Patterns of doramectin tissue residue depletion in parasitized vs nonparasitized lambs

et al. 2008

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The effect of gastrointestinal parasitism on patterns of edible tissue depletion of doramectin was studied in greyface Suffolk lambs. Twelve weight-matched pairs of lambs were allocated into group I (nonparasitized, pretreated with three administrations of 5 mg/kg fenbendazole) and group II (parasitized, did not receive anthelmintic treatment). Both groups were maintained together under similar conditions for 70 days, when they were treated with a subcutaneous dose of 0.2 mg/kg bw doramectin. At 7, 14, 21, and 28 days after doramectin administration, three lambs from each group were slaughtered and samples of liver, kidney, muscle, and fat were obtained. Pre-treatment with fenbendazole significantly reduced the nematode fecal egg count and significantly increased lamb body weight compared to the parasitized group. Doramectin was detected in all of the tissues up to 28 days post-treatment. Significantly higher and more persistent doramectin concentrations were found in the nonparasitized lambs compared to the parasitized animals. Considering the EMEA maximum residue limits for doramectin in fat, the calculated withdrawal period for the healthy lambs (43 days) was significantly higher than that for the parasitized animals (26 days).

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Section: Analytical Methodology Validationsupporting

confidence: 92%

Section: Introductionsupporting

confidence: 59%

Section: Introductionmentioning

confidence: 91%

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Patterns of doramectin tissue residue depletion in parasitized vs nonparasitized lambs

et al. 2008

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“…On the day of treatment, counts for calves of the Ivomec Plus group were significantly lower than counts for calves of the other two treatment groups. This uneven dispersal of patent infections prior to day0 may have beneficially biased the perceived effectiveness of Ivomec Plus relative to the other products in the test as fecal egg counts and drug availabilities have been shown to be negatively correlated (Perez et al 2006;Lespine et al 2004). In this test, however, neither ivermectin product significantly reduced egg counts, whereas treatment with Means with no lowercase letter in common differ (P < 0.05) were most heavily dependent upon class of treatment compound as opposed to animal source and are therefore summarized on a class of compound basis across all tests and sample dates in Fig.…”

Section: Fecal Egg Count Reductionsmentioning

confidence: 98%

Effectiveness evaluation of several cattle anthelmintics via the fecal egg count reduction test

et al. 2009

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Utilizing groups of cograzed, naturally infected beef-type heifers, three fecal egg count reduction tests were conducted in the later months of 2007 at the University of Arkansas. Each test was 28 days in length consisting of individual animal fecal nematode egg counts and coprocultures. Both original and generic ivermectin injectable formulations were used in two of the tests at 0.2 mg/kg BW, with FECR percentages never exceeding 90% in either test. Oral fenbendazole was evaluated at 5 and 10 mg/kg BW, with FECR%'s exceeding 90% on all occasions, but with a precipitous drop when recently treated animals were treated at the lower dose. Evaluated in one test, injectable moxidectin given at 0.2 mg/kg BW resulted in egg count reductions of 96-92% (days 7 to 28). Also evaluated in one test, albendazole delivered orally at 10 mg/kg BW was 98% and 97% effective at 17 and 28 days post-treatment. For all tests, coprocultures conducted post-treatment contained only Cooperia spp. larvae (benzimidazole use), relatively unmodified percentages of Cooperia spp. and Haemonchus spp. larvae (ivermectin use), and primarily Cooperia spp. larvae with a small percentage of Haemonchus spp. larvae (moxidectin use).

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“…MLs are characterized by a unique long mean residence time (MRT) in the host associated with long-lasting activity when compared with other anthelmintics such as benzimidazoles. The pharmacokinetic behavior of MLs depends upon the route of administration, the formulation used, the animal species, and pathophysiological status of the host (Alvinerie et al 1998;Baggot and McKellar 1994;Bassissi et al 2004b;Hennessy and Alvinerie 2002;Lespine et al 2004;Perez et al 2002). Ivermectin is available for oral, subcutaneous, and topical administration.…”

Section: Introductionmentioning

confidence: 99%

Assessment of a liposomal formulation of ivermectin in rabbit after a single subcutaneous administration

Bassissi¹,

Lespine²,

Alvinerie³

2005

Parasitol Res

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Ivermectin is a member of the macrocyclic lactone family widely used in livestock, pets, and humans as a potent parasiticide. Slight differences in formulation may change the plasma kinetics and efficacy of these compounds. The aim of the study is to evaluate the ability of a liposomal formulation of ivermectin to generate an efficient exposure of the animal to the drug. Ten rabbits were subcutaneously administered with 0.3 mg kg(-1) of ivermectin using Ivomec (n=5) or a liposomal formulation (n=5). The areas under serum concentration-time curve were similar after both treatments, indicating the same bioavailability for the two formulations. However, the liposomal formulation gave a higher C(max) value (33.33 ng ml(-1)) compared with Ivomec (20.82 ng ml(-1)) and a significantly faster absorption as indicated by the T(max) of 0.23 days compared with 1.13 days for the Ivomec formulation. The use of liposomal formulation shows promise as this system improves the efficacy of ivermectin and related drugs.

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The influence of parasitism on the pharmacokinetics of moxidectin in lambs

Cited by 32 publications

References 25 publications

Patterns of doramectin tissue residue depletion in parasitized vs nonparasitized lambs

Patterns of doramectin tissue residue depletion in parasitized vs nonparasitized lambs

Effectiveness evaluation of several cattle anthelmintics via the fecal egg count reduction test

Assessment of a liposomal formulation of ivermectin in rabbit after a single subcutaneous administration

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