Objective-Environmental and cultural factors, as well as a genetic variant of the aldehyde dehydrogenase gene (the ALDH2*2 allele) have been identified as correlates of alcohol use among Asian Americans. However, concurrent examination of these variables has been rare. The present study assessed parental alcohol use, acculturation and ALDH2 gene status in relation to lifetime, current and heavy episodic drinking among Chinese and Korean American undergraduates.Method-Participants (N = 428, 51% women; 52% Chinese American, age 18-19 years) were firstyear college students in a longitudinal study of substance use initiation and progression. Data were collected via structured interview and self-report, and participants provided a blood sample for genotyping at the ALDH2 locus.Results-Gender, parental alcohol use and acculturation significantly predicted drinking behavior. However, none of the hypothesized moderating relationships were significant. In contrast with previous studies, ALDH2 gene status was not associated with alcohol use.
Conclusions-Resultsindicate that although the variables examined influence alcohol use, moderating effects were not observed in the present sample of Asian American college students. Findings further suggest that the established association ALDH2 status and drinking behavior in Asians may not be evident in late adolescence. It is possible that ALDH2 status is associated with alcohol consumption only following initiation and increased drinking experience.Asian Americans Comprise the fastest-growing ethnic minority population in the United States (Varma and Siris, 1996); accordingly, understanding the etiology of substance use in this group is increasingly important. It has been noted that substance use prevention initiatives should attend to culture-specific factors influencing use among emergent ethnic minority populations (Castro and Alarcon, 2002;Unger et al., 2002). To accomplish this goal it is necessary to first identify such factors, as well as to determine how culture-specific variables give rise to crossethnic differences in substance use. As adolescence is often marked by initiation and escalation of substance use (O'Malley et al., 1998), studies of Asian American youth are important to the identification of etiologic factors specific to alcohol and other drug use in this population.