The influence of phase II conjugation on the biological activity of flavonoids

New Analytical Methods Measuring Conjugates of Phytochemicals Should Be Developed When Studying the Effect of a Plant-Based Diet on Human Health

“…Second, it can provide a basis for more correct interpretation of the results, because the biological activity of cojugates is not necessarily similar to their precursors and bridges the gap of knowledge on the role of phytochemicals in human health. These aspects are important when considering the work performed by Beekmann, “The Influence of Phase II Conjugation on the Biological Activity of Flavonoids”, which addresses the importance of conjugation when studying the biological activity of these compounds . He studied the effect of glucuronidation of phytochemicals, quercetin, kaempferol, genistein, and daidzein on the peroxisome proliferator-activated receptor γ (PPAR-γ), estrogen receptor (ERα and ERβ), and the potential to inhibit serine/threonine protein kinases in vitro .…”

“…In all three cases, glucuronidation diminished the effects compared to the precursor molecule. It was highlighted that conjugation altered the biological activity compared to the precursor molecule and that conjugated flavonoids may exert biological activities themselves, which was considered as the key to understand how these compounds may influence human health . This is one of the comprehensive studies that has been performed with conjugated phytochemicals.…”

“…These aspects are important when considering the work performed by Beekmann, "The Influence of Phase II Conjugation on the Biological Activity of Flavonoids", which addresses the importance of conjugation when studying the biological activity of these compounds. 5 He studied the effect of glucuronidation of phytochemicals, quercetin, kaempferol, genistein, and daidzein on the peroxisome proliferator-activated receptor γ (PPAR-γ), estrogen receptor (ERα and ERβ), and the potential to inhibit serine/threonine protein kinases in vitro. In all three cases, glucuronidation diminished the effects compared to the precursor molecule.…”