The Influence of Physical Activity, Mental Stress and Injury on the Hemostatic Mechanism

Ogston, D.

doi:10.1007/978-1-4684-7319-3_11

Cited by 3 publications

(4 citation statements)

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“…This raises the question whether the Ramadan fast induces a hypercoagulable prothrombotic state similar to that associated with other forms of stress [9]. Our results indicate the opposite, as we observed a lower platelet aggegability in Ramadan than during the nonfasting day.…”

Section: Discussioncontrasting

confidence: 55%

“…1; 1991 Findings from a previous study have suggested that the incidence of renal colic and angina pectoris increases noticeably during Ramadan, especially when it falls in the hot summer season [1]. This raises the question whether the Ramadan fast induces a hypercoagulable prothrombotic state similar to that associated with other forms of stress [9]. Our results indicate the opposite, as we observed a lower platelet aggegability in Ramadan than during the nonfasting day.…”

mentioning

confidence: 53%

“…Previous studies on the physiological responses to Ramadan fasting have documented biochemical [1][2][3][4][5][6][7], hematological [3,6,8], and hormonal [4] changes, but no studies have been done to investigate the responses of the hemostatic system. The total fast during an ordinary working day is stressful, and it is well established that a wide variety of stressful stimuli produce measurable effects on platelet function, coagulation, and fibrinolysis [9].…”

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confidence: 99%

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The Effect of Fasting in Ramadan on Hemostatic Variables

Kordy

Gader

1991

Ann Saudi Med

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Hemostatic measurements were performed in 33 volunteers in the morning and afternoon in one day during the Muslim fasting month of Ramadan, and were then repeated on an ordinary nonfasting day. There were no significant diurnal fluctuations in plasmatic hemostatic parameters either in Ramadan or on a nonfasting day. There was no difference in the morning and afternoon platelet aggregation responses between Ramadan and the nonfasting period. However, aggregation responses to ADP (2 μM/L), adrenaline, collagen, and arachidonic acid were diminished during Ramadan as compared to the nonfasting day. It is concluded that the stress encountered during the Ramadan fast, as depicted in the platelet aggregation responses, is less than that encountered on an ordinary nonfasting day.MT Kordy, AGMA Gader, The Effect of Fasting in Ramadan on Hemostatic Variables. 1991; 11(1): 23-27 The fasting month of Ramadan is the ninth lunar month of the Muslim calendar. It is during this time when all Muslims are obliged to observe a dawn to sunset fast, but may consume any food and drink from sunset to dawn. Previous studies on the physiological responses to Ramadan fasting have documented biochemical [1][2][3][4][5][6][7], hematological [3,6,8], and hormonal [4] changes, but no studies have been done to investigate the responses of the hemostatic system. The total fast during an ordinary working day is stressful, and it is well established that a wide variety of stressful stimuli produce measurable effects on platelet function, coagulation, and fibrinolysis [9].We report the results of measurements of a variety of hemostatic variables, including platelet aggregation, in healthy volunteers observing the Ramadan fast. The same measurements were repeated in an ordinary working day. As far as we know, no similar study has been done before. Material and MethodsA total of 33 volunteers (30 males, 3 females) were studied (mean age, 32 ± 4.98 yr SD; mean weight, 69.9 ± 7.98 kg SD). They were members of the academic, technical, or clinical staff, or students at the College of Medicine, as well as members of the general public. Only three subjects smoked an average of less than 10 cigarettes per day; the rest were nonsmokers.Ramadan blood samples were obtained at 9:00 A.M. and 3:00 P.M., five and ten hours after the last intake of food or drink during a working day inthe third week of Ramadan (9:00 A.M. and 3:00 P.M. are the start and end of the working day during Ramadan). The same subjects were studied again during a nonfasting day (working hours, 7:30 A.M. to 4:30 P.M.), and blood samples were drawn at the same time of day as during the fasting period. The 7:30 A.M. sample was taken after the subject had ingested a cup of tea and biscuits but no fatty food; the 4:30 P.M. samples were collected approximately 2 to 3 hours after an ordinary lunch had been eaten. Blood samples were collected from an antecubital vein with the minimum of venous stasis and added to sodium citrate (0.11 M) in a vacutainer plastic tube (Sarstedt, West Germany) to ...

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Section: Discussioncontrasting

confidence: 55%

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confidence: 53%

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confidence: 99%

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The Effect of Fasting in Ramadan on Hemostatic Variables

Kordy

Gader

1991

Ann Saudi Med

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“…The question of whether the stress of the RIF would induce a hypercoagulable prothrombotic state resembling that associated with other forms of stress 49 is a matter of debate. When observing the fasting, Muslims are also obliged to perform many religious rituals which make peace of mind a salient feature of Ramadan.…”

Section: Discussionmentioning

confidence: 99%

Ramadan intermittent fasting is associated with improved anticoagulant activity among healthy people: a case–control study

Al-Ghumlas

2024

Sci Rep

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Data on the pathophysiological mechanisms of hemostatic alterations in the thrombotic events that occur during Ramadan intermittent fasting (RIF), particularly in the natural coagulation inhibitors, are very limited. Thus, our objective was to evaluate the effect of RIF on the natural anticoagulants level, antithrombin, protein C, and total and free protein S (PS) in healthy participants. Participants were divided into two groups. Group I consisted of 29 healthy fasting participants whose blood samples were taken after 20 days of fasting. Group II included 40 healthy non-fasting participants whose blood samples were taken 2–4 weeks before the month of Ramadan. Coagulation screening tests including prothrombin time (PT), activated partial thromboplastin time (APTT) and plasma fibrinogen level, natural anticoagulants; antithrombin, protein C, free and total PS and C4 binding protein (C4BP) levels were evaluated in the two groups. High levels of total and free PS without change in antithrombin, protein C, and C4BP levels were noted in the fasting group as compared with non-fasting ones (p < 0.05). PT and APTT showed no difference between the two groups. However, the fibrinogen level was higher in the fasting group. In conclusion, RIF was found to be associated with improved anticoagulant activity in healthy participants, which may provide temporal physiological protection against the development of thrombosis in healthy fasting people.

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