The Influence of Pituitrin on Respiration

Abstract

The APS Journal Legacy Content is the corpus of 100 years of historical scientific research from the American Physiological Society research journals. This package goes back to the first issue of each of the APS journals including the American Journal of Physiology, first published in 1898. The full text scanned images of the printed pages are easily searchable. Downloads quickly in PDF format.

Society Proceedings

“…The sympa¬ thetic system offers no exception to the general increase of irritability that results from parathyroid extirpation. 11. Influence of Epinephrin on Respiration.-The effect of epinephrin on respiration it was found occurs synchronously with that on the circulartory system.…”

Some observations on the mechanism of adrenaline hyperpnoea

“…Fig. 8d Nice et al (1914), Nice & Neill (1925), Jackson (1916) and McDowall (1928); Garrelon & Langlois (1913) found a marked acceleration of respiratory rate in dogs. The type of response varied with each preparation and the duration of the anaesthesia.…”

“…The mechanism of this hyperpnoea is still ill defined. The increased respiration is brought about chiefly by an increase in tidal volume with little alteration in respiratory rate in both the anaesthetized animal (Nice et al 1914;Jackson, 1916;Nice & Neill, 1925) and in conscious man (Boothby & Sandiford, 1923;Cori & Buchwald, 1930;Courtice et al 1939;Whelan & Young, 1953). In the anaesthetized animal it has been shown to be independent of changes in cerebral or systemic blood pressure and of the integrity of the vagus (Nice et al 1914;Nice & Neill, 1925).…”

“…The increased respiration is brought about chiefly by an increase in tidal volume with little alteration in respiratory rate in both the anaesthetized animal (Nice et al 1914;Jackson, 1916;Nice & Neill, 1925) and in conscious man (Boothby & Sandiford, 1923;Cori & Buchwald, 1930;Courtice et al 1939;Whelan & Young, 1953). In the anaesthetized animal it has been shown to be independent of changes in cerebral or systemic blood pressure and of the integrity of the vagus (Nice et al 1914;Nice & Neill, 1925). It has been suggested that the hyperpnoeic response is due to the direct stimulating action of adrenaline on the respiratory centre (McDowall, 1928;Heymans & Bouckaert, 1930;Wright, 1930) or that it is simply the result of the increased metabolic rate (Boothby & Sandiford, 1923).…”