The Influence of Polymorphisms in the MxA Promoter and the elF-2α Regulatory Region 2 on the Natural outcome of HBV Infection

Human Embryos Genetically Modified: A Review

“…It remains illegal to alter the genomes of embryos used to conceive a child in the UK, but according to researchers this license could resolve the debate over deploying geneediting in embryos for therapeutic uses in the clinic. This study may find the genetic modifications could help researchers to develop treatments for infertility [136][137][138][139][140]. Further federal biosafety and ethics panel approved the genome-editing technology's first ever study in patients.…”

Polymorphisms Within the Promoter Region of the Gamma Interferon (IFN-γ) Receptor1 Gene are Associated With the Susceptibility to Chronic HBV Infection in an Iranian Population

“…Nucleotide variations in the regulatory regions of coding cytokine genes and their receptors can lead to modulation in the cytokine expression, a large number of evidences indicate that SNPs within the binding site of transcription factors may cause decrease in the promoter function of a cytokine/receptor complex and thus can affect the symptoms of a disease (7, 8). The host genetic backgrounds, especially (SNPs) can be a marker of the clinical heterogeneity of HBV infection (17, 19). IFN-γ has a heterodimeric receptor that is made up of two chains (IFN-γ R1 and IFN-γ R2), that each mediates a specific function; IFN-γ R1 is involved in binding to the ligand (IFN-γ) and IFN-γ R2 plays a role in the signaling pathway (6).…”