The Influence of Porcine Calcitonin Given Intragastrally on Restraint-Induced Gastric Ulcers in Pigs

Abstract

Gastric ulcers, located in the fundic area, appeared in pigs restrained during a 24 hrs period. Tbe development of tbese uleers was prevented by poreine calcitonin (P-CT) given intramuscuiarly or intragastraIly, at 5 hrs intervals, during tbe restraint period. P-CT increased significantly tbe pH of gastrie secretion at the end of restraint. In non-restrained fasting pigs, P-CT given intragastraIly strongly inbibited basal or gastrin-stimulated acid output. These results tend to indicate that P-CT prevented restraint-induced gastric ulcer in pigs, probably by inbibiting gastric HCl secretion.

PROCEEDINGS OF THE British Pharmacological Society

“…Many of the non-steroidal antiinflammatory drugs, such as indomethacin and aspirin, may induce gastric ulceration. In contrast the hormone calcitonin has an antiinflammatory action in several animal models (Abdullahi, De Bastiani, Nogarin & Velo, 1975) but inhibits gastric acid secretion (Becker, Konturek, Reeder & Thompson, 1973) and gastric ulceration induced by stress (Barlet, 1974) or histamine . These latter inhibitory effects of calcitonin have been demonstrated after parenteral or intragastral administration (Barlet, 1974).…”

“…In the pig, Barlet (1974) demonstrated an effect on stress-induced gastric ulceration using an intragastric dose of 10 times the intramuscular dose. Other workers have shown similar or lower ratios of effective doses for calcitonin when administered to rat and man (Ziegler, Minne Hotz & Goebel,, 1974;, by these two routes of administration.…”