The Influence of Pregnancy on Behçet’s Disease

Bang, Duhee; Chun, Yoon S.; Haam, Ik Byeong; Lee, Eun‐So; Lee, Sungnack

doi:10.1007/978-3-642-56455-0_26

Cited by 10 publications

(28 citation statements)

References 9 publications

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“…Overall, the rate of BD flares during pregnancy varies from 8% (20) to 60% (26). Consistent with our results, BD flares consist mainly of oral and genital ulcerations (10,21,26).…”

Section: Discussionsupporting

confidence: 90%

“…By adding the data provided in the literature to those obtained in our study, a series of 279 pregnancies in 159 patients was available for analysis. Overall, BD flares occurred in 29.7% of the pregnancies (ranging from 8% [20] to 60% [26] in the literature). In these series, the main symptoms during BD flares were oral ulceration (58.…”

Section: Resultsmentioning

confidence: 96%

“…Interestingly, of the 7 patients with obstetric complications, 5 had a history of venous thrombosis in BD prior to pregnancy (deep vein thrombosis [DVT], alone [n ϭ 2] or associated with dural sinus thrombosis [n ϭ 2]; pulmonary Comparison with series from the literature. Six series analyzing the interaction between BD and pregnancy have been published (10,(19)(20)(21)(22)26) and also were recently reviewed (29). By adding the data provided in the literature to those obtained in our study, a series of 279 pregnancies in 159 patients was available for analysis.…”

Section: Resultsmentioning

confidence: 99%

“…We added relevant articles that were not identified using this strategy but were present in the reference list of other studies. In total, 6 series with more than 2 patients were analyzed (10,(19)(20)(21)(22)26), along with one recent review of the literature (29).…”

Section: Methodsmentioning

confidence: 99%

“…Finally, treatment of BD during pregnancy is an important issue because of possible adverse effects that may also affect pregnancy outcome. Nonetheless, observational studies of pregnant women with BD remain sparse and consist mainly of small series or case reports (8)(9)(10)(11)(12)(13)(19)(20)(21)(22)(23)(24)(25)(26)(27).…”

mentioning

confidence: 99%

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Behçet's Disease and Pregnancy

Noël

Wechsler

Nizard

et al. 2013

Arthritis & Rheumatism

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Objective. To describe the interplay between Behçet's disease (BD) and pregnancy.Methods. This retrospective study included 76 pregnancies in 46 patients fulfilling the international criteria for BD. The median age of the patients at the time of entry into the study was 28.4 years (interquartile range 22.8-30.9 years). Patients were used as their own historical controls to assess the incidence of BD flares during pregnancy and before or after pregnancy. Factors associated with the occurrence of complications during pregnancy were assessed.Results. Among the 76 pregnancies with BD analyzed, 27 (35.5%) were associated with worsening of the symptoms of BD flare; oral and genital ulcerations (78.4% and 67.6%, respectively) as well as ocular complications (32.4%) were the most frequent. The mean ؎ SD annual rates of BD flares were 0.49 ؎ 0.72 during pregnancy and 1.46 ؎ 2.42 during the nonobstetric period (P ‫؍‬ 0.018). The proportion of BD flares tended to be lower in patients treated with colchicine (27.9% versus 45.4% of patients not treated with colchicine; P ‫؍‬ 0.11). The overall rate of complications during pregnancy was 15.8%. The complications included miscarriage (5 patients), cesarean delivery (3 patients), medical termination of pregnancy (2 patients), hemolysis, elevated liver enzymes, and low platelets syndrome (1 patient), and immune thrombocytopenia (1 patient). There was a statistically significant association between a history of deep vein thrombosis in BD and the risk of obstetric complications (odds ratio 7.25, 95% confidence interval 1.21-43.46, P ‫؍‬ 0.029). Neither gestational age at delivery nor neonatal outcome was influenced by BD.Conclusion. The disease course in BD seems to improve during pregnancy, mostly in patients who are treated with colchicine. Pregnancy in patients with BD appears not to be associated with an increased rate of pregnancy-related complications.

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“…Overall, the rate of BD flares during pregnancy varies from 8% (20) to 60% (26). Consistent with our results, BD flares consist mainly of oral and genital ulcerations (10,21,26).…”

Section: Discussionsupporting

confidence: 90%

Section: Resultsmentioning

confidence: 96%