The influence of prenatal and intrapartum antibiotics on intestinal microbiota colonisation in infants: A systematic review

Dierikx, Thomas H.; Visser, Douwe H.; Benninga, Marc A.; Kaam, A.H.L.C. van; Boer, Nanne K. H. de; Vries, Ralph de; Limbergen, Johan Van; Meij, T.G.J. de

doi:10.1016/j.jinf.2020.05.002

Cited by 83 publications

(65 citation statements)

References 72 publications

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“…Host-microbiome interactions enable early life education and maturation of the immune system during a window of opportunity. The use of prenatal and intrapartum antibiotics may disturb this process (Dierikx et al, 2020). However, the timing of the microbial colonization of the mammalian gut is still unclear (Perez-Munoz et al, 2017;Korpela and de Vos, 2018;Liu et al, 2019;Guzman et al, 2020;Blaser et al, 2021;Silverstein and Mysorekar, 2021).…”

Section: Introductionmentioning

confidence: 99%

The Composition of the Microbiota in the Full-Term Fetal Gut and Amniotic Fluid: A Bovine Cesarean Section Study

et al. 2021

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The development of a healthy intestinal immune system requires early microbial exposure. However, it remains unclear whether microbial exposure already begins at the prenatal stage. Analysis of such low microbial biomass environments are challenging due to contamination issues. The aims of the current study were to assess the bacterial load and characterize the bacterial composition of the amniotic fluid and meconium of full-term calves, leading to a better knowledge of prenatal bacterial seeding of the fetal intestine. Amniotic fluid and rectal meconium samples were collected during and immediately after elective cesarean section, performed in 25 Belgian Blue cow-calf couples. The samples were analyzed by qPCR, bacterial culture using GAM agar and 16S rRNA gene amplicon sequencing. To minimize the effects of contaminants, we included multiple technical controls and stringently filtered the 16S rRNA gene sequencing data to exclude putative contaminant sequences. The meconium samples contained a significantly higher amount of bacterial DNA than the negative controls and 5 of 24 samples contained culturable bacteria. In the amniotic fluid, the amount of bacterial DNA was not significantly different from the negative controls and all samples were culture negative. Bacterial sequences were identified in both sample types and were primarily of phyla Proteobacteria, Firmicutes, Bacteroidetes, and Actinobacteria, with some individual variation. We conclude that most calves encounter in utero maternal-fetal transmission of bacterial DNA, but the amount of bacterial DNA is low and viable bacteria are rare.

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Section: Introductionmentioning

confidence: 99%

The Composition of the Microbiota in the Full-Term Fetal Gut and Amniotic Fluid: A Bovine Cesarean Section Study

et al. 2021

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“…When it comes to infectious diseases, the problem emerged as antibiotics, especially the broad-spectrum ones cannot distinguish the intestinal beneficial bacteria from the exogenous harmful bacteria (Blaser, 2016;Lange et al, 2016). Many previous reports showed that antibiotic treatments altered the composition of intestinal microbiota, resulting in an increased risk of many other illnesses (Blaser, 2011;Angelucci et al, 2019;Dierikx et al, 2020;Zwittink et al, 2020). For instance, intestinal inflammation that is tightly linked with altered gut microbiota might be triggered by antibiotic treatment (Belkaid and Hand, 2014;Slager et al, 2014;Becattini et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

Comparison of the Gut Microbiota Between Pulsatilla Decoction and Levofloxacin Hydrochloride Therapy on Escherichia coli Infection

Liu

et al. 2020

Front. Cell. Infect. Microbiol.

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Gut microbiota serves as a critical indicator for gut health during treatment of pathogenic bacterial infection. Both Pulsatilla Decoction (abbreviated to PD, a traditional Chinese medicine compound) and Levofloxacin Hydrochloride (LVX) were known to have therapeutic effects to intestinal infectious disease. However, the changes of gut microbiota after PD or LVX treatment remain unclear. Herein, this work aimed to investigate the changes of intestinal flora after PD or LVX therapy of Escherichia coli infection in rats. Results revealed that PD exhibited a valid therapeutic approach for E. coli infection via the intestinal protection, as well as the inhibited release of IL-8 and ICAM-1. Besides, PD was beneficial to rebuild the gut microbiota via restoring Bacteroidetes spp in the composition of the gut microbiota. Comparatively, LVX treatment promoted the infection and ravaged gut microbiota by significantly decreasing Bacteroidetes and increasing Firmicutes. These findings not only highlight the mechanism of Chinese herbal formula, but extend the application of PD as veterinary medicine, feed additive and pre-mixing agent for improving the production of animal derived foods.

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“…For example, early administration of oral antibiotics to newborn rats resulted in significant gut microbiota changes, indicating that Proteobacteria and Bacteroidetesreplaced Firmicutes and Actinobacteria , and the concomitant descent in the proportion of Clostridia andBacilli was accompanied by an increment inGammaProteobacteria 20 . Furthermore, remarkable changes in gut microbiota diversity were observed in infants exposed to antibiotics both prenatally and during the intrapartum stages, especially in terms of decreases observed in Bacteriodetes andBifidobacteria and an increase inProteobacteria 21 . Another study showed that postnatal antibiotic exposure was associated with significantly lower levels of Enterococcus and Lactobacillus in the intestines of preterm infants, with Enterococcus thought to be associated with immunomodulation 22 and Lactobacillusexhibiting powerful anti-inflammatory properties 23 .…”

Section: A Brief Retrospect Of the Gut Microbiotamentioning

confidence: 99%

Gut microbiota and bronchopulmonary dysplasia

Yang

Dong

2021

Preprint

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Bronchopulmonary dysplasia is a relatively common and severe complication of prematurity, and its pathogenesis remains ambiguous. Revolutionary advances in microbiological analysis techniques, together with the growing sophistication of the gut-lung axis hypothesis, have resulted in more studies linking gut microbiota dysbiosis to the occurrence and development of bronchopulmonary dysplasia. The present article builds on current findings to examine the intrinsic associations between gut microbiota and bronchopulmonary dysplasia. The gut microbiota affects bronchopulmonary dysplasia via several potential mechanisms including alteration of the gut-lung axis, promotion of inflammation and the ensuing growth effects, therefore these are also investigated. By evaluating the potential mechanisms, new therapeutic targets and potential therapeutic modalities for BPD can be identified from a microecological perspective.

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The influence of prenatal and intrapartum antibiotics on intestinal microbiota colonisation in infants: A systematic review

Cited by 83 publications

References 72 publications

The Composition of the Microbiota in the Full-Term Fetal Gut and Amniotic Fluid: A Bovine Cesarean Section Study

The Composition of the Microbiota in the Full-Term Fetal Gut and Amniotic Fluid: A Bovine Cesarean Section Study

Comparison of the Gut Microbiota Between Pulsatilla Decoction and Levofloxacin Hydrochloride Therapy on Escherichia coli Infection

Gut microbiota and bronchopulmonary dysplasia

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