The influence of probiotics on gastrointestinal tract infections among children attending childcare: A systematic review and meta-analysis

Ahmad, Hafiz Haris; Peck, Blake; Terry, Daniel

doi:10.1111/jam.15374

Cited by 4 publications

(1 citation statement)

References 34 publications

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“…The American Gastroenterology Association issued guidance that probiotics may be useful for (1) prevention of Clostridioides difficile infection in adults and children taking antibiotics, (2) prevention of necrotizing enterocolitis in preterm, low birthweight infants, and (3) management of pouchitis, a complication of inflammatory bowel disease [ 3 ]. Several meta-analyses support the use of probiotics to mitigate antibiotic-associated diarrhea [ 4 , 5 ] and gastrointestinal (GI) infections among infants and children [ 6 , 7 ]. These data highlight the potential role of probiotics in modulating the gut immune response and mitigating the expansion of pathogenic bacteria.…”

Section: Introductionmentioning

confidence: 99%

The Probiotic Bacillus subtilis MB40 Improves Immunity in a Porcine Model of Listeriosis

Garvey,

Emami,

Guice

et al. 2023

Microorganisms

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Probiotics for humans and direct-fed microbials for livestock are increasingly popular dietary ingredients for supporting immunity. The aim of this study was to determine the effects of dietary supplementation of Bacillus subtilis MB40 (MB40) on immunity in piglets challenged with the foodborne pathogen Listeria monocytogenes (LM). Three-week-old piglets (n = 32) were randomly assigned to four groups: (1) basal diet, (2) basal diet with LM challenge, (3) MB40-supplemented diet, and (4) MB40-supplemented diet with LM challenge. Experimental diets were provided throughout a 14-day (d) period. On d8, piglets in groups 2 and 4 were intraperitoneally inoculated with LM at 108 CFU/mL per piglet. Blood samples were collected at d1, d8, and d15 for biochemical and immune response profiling. Animals were euthanized and necropsied at d15 for liver and spleen bacterial counts and intestinal morphological analysis. At d15, LM challenge was associated with increased spleen weight (p = 0.017), greater circulating populations of neutrophils (p = 0.001) and monocytes (p = 0.008), and reduced ileal villus height to crypt depth ratio (p = 0.009), compared to non-challenged controls. MB40 supplementation reduced LM bacterial counts in the liver and spleen by 67% (p < 0.001) and 49% (p < 0.001), respectively, following the LM challenge, compared to the basal diet. MB40 supplementation was also associated with decreased circulating concentrations of monocytes (p = 0.007). Altogether, these data suggest that MB40 supplementation is a safe and well-tolerated approach to enhance immunity during systemic Listeria infection.

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Section: Introductionmentioning

confidence: 99%

The Probiotic Bacillus subtilis MB40 Improves Immunity in a Porcine Model of Listeriosis

Garvey,

Emami,

Guice

et al. 2023

Microorganisms

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Dietary Supplements and Common Viral Infections: “Boosting” the Immune System or the Manufacturers’ Profits?

Kramer

2023

Believe It or Not

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Administration of probiotics to healthy volunteers: effects on reactivity of intestinal mucosa and systemic leukocytes

et al. 2022

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Background Oral administration of health-promoting bacteria is increasingly used in clinical practise. These bacteria have anti-inflammatory characteristics and modulate the immune system without major reported side effects. The mechanisms of action are not yet fully defined. Our aim was to study systemic effects of probiotics by measurements of leukocytes as well as local effects on rectal mucosal biopsies after adding a standardized inflammatory stimulus in vitro. Methods Fourteen healthy subjects were randomized to receive 1010 colony forming units/day orally of the probiotic strain Lactiplantibacillus plantarum 299 (Lp299), n = 7, or Bifidobacterium infantis CURE21 (CURE21), n = 7, for six weeks. Rectal biopsies were taken before and after ingestion of either probiotic strain product, for stimulation in vitro with tumour necrosis factor alpha (TNF-α) at 10 and 100 ng/ml respectively up to 8 h. Blood tests were sampled before and after treatment. Lactate dehydrogenase (LDH) confirmed viable tissue. Results Composition of the intestinal microbiota was not changed. Systemic leukocytes decreased after administration of CURE21 (P<0.05) and Lp299 (P<0.01). Levels of the pro-inflammatory cytokine IL-6 in rectal mucosa after stimulation with TNF-α were attenuated after ingestion of Lp299. No effect was seen with CURE21. Conclusions Administration of these probiotic strains to healthy humans show both a systemic and local reduction of inflammatory response by lowering leukocyte counts, and for Lp299 IL-6 levels in rectal mucosa. Probiotics may play an important role in the reduction of inflammatory responses expected after trauma during surgery or after pelvic irradiation. Trial registration Clinical Trials, registration number NCT01534572, retrospectively registered (http://www.clinicaltrials.gov).

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The influence of probiotics on gastrointestinal tract infections among children attending childcare: A systematic review and meta-analysis

Cited by 4 publications

References 34 publications

The Probiotic Bacillus subtilis MB40 Improves Immunity in a Porcine Model of Listeriosis

The Probiotic Bacillus subtilis MB40 Improves Immunity in a Porcine Model of Listeriosis

Dietary Supplements and Common Viral Infections: “Boosting” the Immune System or the Manufacturers’ Profits?

Administration of probiotics to healthy volunteers: effects on reactivity of intestinal mucosa and systemic leukocytes

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