The influence of processed total non-forward and non-motile sperm count on the outcome of artificial insemination with the husband’s semen

Abstract

Background: Artificial insemination with the husband's semen (AIH) is an economical and noninvasive method of infertility treatment. However, AIH's pregnancy rate is much lower than in vitro fertilization (IVF) as its multiple and complex uncertainty factors. Semen quality has been one of the main factors which affect the pregnancy outcome of AIH.Methods: The relevant parameters of 1,142 AIH cycles were retrospectively studied, including the general parameters and the semen quality parameters among clinical pregnancy, biochemical pregnancy, nonpregnancy group, age, infertility duration, infertility type, body mass index (BMI), cycle count, morphology in previously semen examination, and semen quality parameters on the day of AIH.Results: The statistically significant difference was only found on processed total non-forward and nonmotile sperm count (N-TFMSC). The mean processed N-TFMSC in the biochemical pregnancy group was 6.37±4.27 million, significantly higher than the other two groups (vs. 4.40±3.15 million or vs. 4.48± 3.60 million, P<0.05). The study was then divided into two groups according to processed N-TFMSC, Group 1 ≤5.0 million, and Group 2 >5.0 million. A statistical increase in biochemical pregnancy rate was observed when the processed N-TFMSC was >5.0 million (2.72% vs. 0.90%).Conclusions: Processed N-TFMSC may be one of the independent factors on AIH's outcome; it should be given equal attention the same as processed total forward motile sperm count (TFMSC).

Associations between vaginal flora, MIP‐1α, IL‐17A, and clinical pregnancy rate in AIH

“…At present, studies concerned with the effects of reproductive tract microbiota on reproduction and assisted reproduction mainly focus on in vitro fertilization and embryo transfer (IVF‐ET) 8 . AIH is more similar to natural pregnancy than to IVF, and the vaginal flora of women is more convenient to sample than endometrium and pelvic flora 9 . The effect of vaginal flora on the clinical pregnancy rate of AIH has not been reported.…”

“…8 AIH is more similar to natural pregnancy than to IVF, and the vaginal flora of women is more convenient to sample than endometrium and pelvic flora. 9 The effect of vaginal flora on the clinical pregnancy rate of AIH has not been reported.…”