The Influence of PUVA and UVB Radiation on Skin-Graft Survival in Rabbits

Morison, Warwick L.; Parrish, John A.; Woehler, Michael E.; Bloch, Kurt J.

doi:10.1111/1523-1747.ep12531069

Cited by 24 publications

(3 citation statements)

References 9 publications

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“…It may play a role in the beneficial effect of PUVA therapy on psoriatic skin by preventing further sensitizing reactions. It has been demonstrated that PUVA treated skin grafts (Morison et al 1980. Gruner et al 1984 or UVB treated pancreatic islet allografts (Lau ct al.…”

Section: Discussionmentioning

confidence: 99%

Inhibition of HLA‐DR antigen expression and of the allogeneic mixed leukocyte reaction by photochemical treatment

et al. 1986

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Treatment of human peripheral blood mononuclear cells with UVB light, the photosensitizing system 8‐methoxypsoralen plus UVA light (PUVA), or hematopor‐phyrin derivative plus visible light leads to an inhibition of their stimulatory capacity in an allogeneic mixed leukocyte reaction despite unaltered expression of HLA‐DR antigens when tested immediately after irradiation. However, HLA‐DR positive cells disappear among mononuclear cells in the interval between 4 and 8 h after treatment with either UVB, PUVA, hematoporphyrin derivative and light, or heating to 45°C. The expression of HLA‐DQ, but not HLA‐A,B,C, antigens, was similarly affected by these treatments. The significance of these results is discussed.

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Section: Discussionmentioning

confidence: 99%

Inhibition of HLA‐DR antigen expression and of the allogeneic mixed leukocyte reaction by photochemical treatment

et al. 1986

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“…(c) Although total body X-irradiation will prolong allografts in normal animals [24], 500-rad treatment to nude rats 1 day prior to engraftment did not increase the length of survival of HSTSG.…”

Section: -mentioning

confidence: 94%

Description of and Treatment to Inhibit the Rejection of Human Split-Thickness Skin Grafts by Congenitally Athymic (Nude) Rats

Gilhar¹,

Wojciechowski²,

Piepkorn³

et al. 1986

Pathobiology

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Gradual rejection of topically engrafted human split-thickness skin grafts (HSTSG) occurred in greater than 90% of congenitally athymic (nude) rats between 21 and 42 days of grafting. Engraftment and rejection of HSTSG is accompanied by a partial restoration of some cell-mediated immune components, the mixed lymphocyte response and lysis of human target cells. Histologic features of the rejection process were those seen in a host-versus-graft reaction. Immunofluorescent analysis of skin undergoing rejection demonstrated IgG at the basement membrane zone in most grafts. Nude rats rejecting HSTSG had circulating IgG which bound to the basement membrane zone and blood vessels of human skin. Nude rats treated with cyclosporine injections for 21 days had an enhanced survival of HSTSG, 120 or more days.

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“…It also diminishes the induction of allergic contact dermatitis and delayed hypersensitivity (Horio & Okamoto 1982;Morison et al 198Ib). Full-thickness graft survival was prolonged in animals after exposure of donors' and recipients' sites (Morison et al 1980). One important factor for these phenomena may be an impairment of Langerhans cell function, represented by the reduction of the epidermal allostimulatory capacity in the mixed epidermal cell-lymphocyte reaction (Van Praag et al 1991).…”

Section: Immunological Alterationsmentioning

confidence: 99%

Minimising the Risks of PUVA Treatment

Praag

Tseng

Mommaas³

et al. 1993

Drug Safety

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Psoralen photochemotherapy (PUVA) is a combination of orally administered psoralen and long wave ultraviolet-A radiation (UVA), and is one of the most effective forms of therapy for psoriasis. The unwanted effects of PUVA therapy can be divided into short and long term adverse effects. The short term adverse effects include erythema, pruritus, nausea and headache. While short term adverse effects are limited and reversible after discontinuation of treatment, potential long term adverse effects such as chronic actinic skin damage, dyskeratotic and precancerous skin conditions, nonmelanoma skin cancer, immunological alterations and cataract formation are of greater concern. Long term risks associated with PUVA therapy can be minimised by several measures. Careful patient selection is mandatory; for example, patients with chronic actinic damage and a history of skin cancer may bear a higher risk for the development of new cancers, and previous arsenic intake and ionising radiation also increase the risk of nonmelanoma skin cancers. Certain drug combinations make it possible to lower the UVA dose, which is important because of the dose-dependent increase in the incidence of squamous cell carcinomas in patients treated with PUVA. It has been demonstrated that 200 treatments or a total UVA dose of 1200 J/cm2 seems to be the threshold for development of nonmelanoma skin cancer. Shielding male genitalia during PUVA treatment is essential because of the increased risk of genital squamous cell carcinomas. Yearly dermatological examination to detect skin cancer at an early stage is highly advisable. Sunscreen use, protective clothing and avoidance of sun exposure reduce the uncontrolled dose of solar UV radiation. Other psoralens with a less carcinogenic potential can be used. UVA-opaque sunglasses during the entire period of increased photosensitivity after psoralen ingestion help avoid cataract formation. Assignment to PUVA ought to be based on the risk-benefit ratio for the individual patient and should be limited to those who can be monitored and controlled by informed, competent and conscientious physicians.

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The Influence of PUVA and UVB Radiation on Skin-Graft Survival in Rabbits

Cited by 24 publications

References 9 publications

Inhibition of HLA‐DR antigen expression and of the allogeneic mixed leukocyte reaction by photochemical treatment

Inhibition of HLA‐DR antigen expression and of the allogeneic mixed leukocyte reaction by photochemical treatment

Description of and Treatment to Inhibit the Rejection of Human Split-Thickness Skin Grafts by Congenitally Athymic (Nude) Rats

Minimising the Risks of PUVA Treatment

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