The influence of reconstruction choice and inclusion of radiation therapy on functional shoulder biomechanics in women undergoing mastectomy for breast cancer

Leonardis, Joshua M.; Diefenbach, Brian J.; Lyons, Daniel; Olinger, Thomas A.; Giladi, Aviram M.; Momoh, Adeyiza O.; Lipps, David B.

doi:10.1007/s10549-018-5003-8

Cited by 18 publications

(14 citation statements)

References 44 publications

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“…Shoulder impedance was quantified by measuring the resultant change in shoulder torque in response to a rapid change in shoulder joint angle. Impedance was then fit to a 2 nd order linear model in the frequency domain to describe the inertial, viscous, and stiffness properties of the shoulder 38,39 . The current study focused on stiffness, as this parameter is most indicative of a clinician’s ability to measure the resistance of the shoulder to movement during clinical examination.…”

Section: Methodsmentioning

confidence: 99%

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Mechanical properties of the shoulder and pectoralis major in breast cancer patients undergoing breast-conserving surgery with axillary surgery and radiotherapy

Lipps

Leonardis

Dess

et al. 2019

Sci Rep

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Breast-conserving surgery (BCS) and radiotherapy reduce breast cancer recurrence but can cause functional deficits in breast cancer survivors. A cross-sectional study quantified the long-term pathophysiological impact of these treatments on biomechanical measures of shoulder stiffness and ultrasound shear wave elastography measures of the shear elastic modulus of the pectoralis major (PM). Nine node-positive patients treated with radiotherapy to the breast and regional nodes after BCS and axillary lymph node dissection (Group 1) were compared to nine node-negative patients treated with radiotherapy to the breast alone after BCS and sentinel node biopsy (Group 2) and nine healthy age-matched controls. The mean follow-up for Group 1 and Group 2 patients was 988 days and 754 days, respectively. Shoulder stiffness did not differ between the treatment groups and healthy controls (p = 0.23). The PM shear elastic modulus differed between groups (p = 0.002), with Group 1 patients exhibiting a stiffer PM than Group 2 patients (p < 0.001) and healthy controls (p = 0.027). The mean prescribed radiotherapy dose to the PM was significantly correlated with passive shear elastic modulus (p = 0.018). Breast cancer patients undergoing more extensive axillary surgery and nodal radiotherapy did not experience long-term functional deficits to shoulder integrity but did experience long-term mechanical changes of the PM.

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Section: Methodsmentioning

confidence: 99%

“…( B ) The rotary motor was positioned to move the arm in the horizontal plane while participants were relaxed or generating shoulder torques in horizontal flexion (forward) or horizontal extension (backward). [Copyrighted figure reprinted from 38 with permission from Springer].…”

Section: Methodsmentioning

confidence: 99%

Mechanical properties of the shoulder and pectoralis major in breast cancer patients undergoing breast-conserving surgery with axillary surgery and radiotherapy

Lipps

Leonardis

Dess

et al. 2019

Sci Rep

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“…Consequently, prepectoral implant placement avoids pectoralis muscle disinsertion, with potential implications on shoulder strength, and avoids postoperative muscle animation deformity. 86,87 Early experience with immediate prepectoral implant reconstructions exposed to PMRT has shown similar complication and failure rates when compared with subpectoral implant reconstructions. 81,88 In fact, radiated patients may have a higher rate of capsular contractures with subpectoral implant reconstructions.…”

Section: Prepectoral Implant Reconstructionmentioning

confidence: 99%

Integration of Breast Reconstruction and Postmastectomy Radiotherapy

Shumway

Momoh

Sabel

et al. 2020

JCO

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“…The BREAST-Q is a newly developed, Patient-Reported Outcome Measure (PROM) that was specifically designed to measure quality of life and patient satisfaction among breast surgery patients [44]. This finding suggest that patients undergo mastectomy without reconstruction can experience psychosocial disturbances and problems with body image and sexuality and provides psychosocial and quality of life benefits [7,45].…”

Section: Improving Satisfaction In Breast Reconstructionmentioning

confidence: 99%

Silicone Implants Biocompatibility after Latissimus Dorsi Flap Reconstruction

Paliyenka

Han

2019

BJSTR

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Background: There are many implications to the ever-growing intimate and necessary involvement of industry in biomedical research for breast reconstruction surgery. Main Body:The major objective of this study to investigate Capsular Contracture (CC) which remains a concern in long-term transplantation and most common complications following silicone implants placement after Latissimus Dorsi flap (LDF) breast reconstruction surgery. CC formation, with special attention paid to immunological and inflammatory reasons, estrogen receptors in peri-prosthetic tissue development, as well as actual prophylactic strategies after breast reconstruction surgery were all investigated. This review summarizes and explores these trends of the association between conflicts of interest and study outcomes in oncoplastic surgery. In addition, we explored whether studies have identified microbial biofilms on various implantable materials and Foreign Body Reaction (FBR). Conclusion:We envision using predictive outcomes of this study to further tailor breast reconstruction procedures according to patients' needs. Moreover, the results can help us to reach the best possible patient counseling, treatment, and care. This work is licensed under Creative Commons Attribution 4.0 License

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The influence of reconstruction choice and inclusion of radiation therapy on functional shoulder biomechanics in women undergoing mastectomy for breast cancer

Cited by 18 publications

References 44 publications

Mechanical properties of the shoulder and pectoralis major in breast cancer patients undergoing breast-conserving surgery with axillary surgery and radiotherapy

Mechanical properties of the shoulder and pectoralis major in breast cancer patients undergoing breast-conserving surgery with axillary surgery and radiotherapy

Integration of Breast Reconstruction and Postmastectomy Radiotherapy

Silicone Implants Biocompatibility after Latissimus Dorsi Flap Reconstruction

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