The influence of renal function on the prognostic value of Nt-pro brain natriuretic peptide in St-elevation myocardial infarction

Lazzeri, Chiara; Valente, Serafina; Chiostri, Marco; Attanà, Paola; Picariello, Claudio; Gensini, Gian Franco

doi:10.1016/j.ijcard.2012.02.010

Cited by 2 publications

(1 citation statement)

References 32 publications

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“…Prior studies have shown that for such patients, NT-proBNP level is significantly correlated with eGFR; in particular, NT-proBNP level increases as eGFR decreases [5,6]. Moreover, investigations have also revealed that the combined use of NT-proBNP level and eGFR can improve the identification of patients at high risk of acute myocardial infarction and heart failure [7][8][9]. Similarly, NT-proBNP levels are influenced by age [10].…”

Section: Introductionmentioning

confidence: 99%

The impact of renal function on the prognostic value of N-terminal pro–B-type natriuretic peptide in patients with coronary artery disease

Chen¹,

Li²,

Ou³

et al. 2020

Cardiol J.

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Section: Introductionmentioning

confidence: 99%

The impact of renal function on the prognostic value of N-terminal pro–B-type natriuretic peptide in patients with coronary artery disease

Chen¹,

Li²,

Ou³

et al. 2020

Cardiol J.

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Amino-Terminal Pro-B-Type Natriuretic Peptide for Diagnosis and Prognosis in Patients With Renal Dysfunction

Schaub

Coca

Moledina

et al. 2015

JACC: Heart Failure

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Structured Abstract Objectives To determine if Amino-terminal Pro B-type Natriuretic Peptide (NT-proBNP) has different diagnostic and prognostic utility in patients with renal dysfunction. Background Patients with renal dysfunction have higher NT-proBNP, which may complicate interpretation for diagnosis of acute decompensated heart failure (ADHF) or prognosis. Methods We searched MEDLINE and EMBASE through August 2014 for studies with a subgroup analysis by renal function of the diagnostic or prognostic ability of NT-proBNP. Results For diagnosis, nine studies were included with 4,287 patients and 1,325 ADHF events. Patients were mostly divided into sub-groups with and without renal dysfunction by an estimated glomerular filtration rate of 60 ml/min/1.73m2. In patients with renal dysfunction, the area under the curve (AUC) for NT-proBNP ranged from 0.66 to 0.89 with a median cut-point of 1980 pg/ml, while the AUC ranged from 0.72 to 0.95 with a cut-point of 450 pg/ml in patients with preserved renal function. For prognosis, 30 studies with 32,203 patients were included, and mortality in patients with renal dysfunction (25.4%) was twice that of patients with preserved renal function (12.2%). The unadjusted pooled risk ratio (RR) for NT-proBNP and mortality was 3.01 (95% CI, 2.53-3.58) in patients with preserved renal function and was similar in patients with renal dysfunction (3.25 [CI, 2.45-4.30]). Upon meta-regression, heterogeneity was partially explained if patients with heart failure or coronary artery disease were enrolled. Conclusions NT-proBNP retains utility for diagnosis of ADHF in patients with renal dysfunction with higher cut-points. Elevated NT-proBNP confers a worse prognosis regardless of renal function.

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The influence of renal function on the prognostic value of Nt-pro brain natriuretic peptide in St-elevation myocardial infarction

Cited by 2 publications

References 32 publications

The impact of renal function on the prognostic value of N-terminal pro–B-type natriuretic peptide in patients with coronary artery disease

The impact of renal function on the prognostic value of N-terminal pro–B-type natriuretic peptide in patients with coronary artery disease

Amino-Terminal Pro-B-Type Natriuretic Peptide for Diagnosis and Prognosis in Patients With Renal Dysfunction

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