The influence of repetitive painful stimulation on peripheral and trigeminal pain thresholds

Dirkwinkel, Monika; Gralow, I.; Çolak-Ekici, Reyhan; Wolowski, Anne; Marziniak, Martin; Evers, Stefan

doi:10.1016/j.jns.2008.07.002

Cited by 6 publications

(3 citation statements)

References 9 publications

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“…If unavoidable noxious stimuli are perceived to pose no threat, pain habituation may help preserve resources. When empirically examining group effects, proportions of habituators and sensitizers reported varies greatly[19,25,70,27,29,32,37,45,50,51,68]. Our finding is the first to indicate that the propensity for an individual to habituate or sensitize to pain is stable within individuals across time and context and, hence, may serve as a valuable phenotypic marker.…”

Section: Discussionmentioning

confidence: 73%

“…In experimental contexts, it is frequently reported that individuals habituate to pain [13,22,25,27,29,37,50,68,70,73]. However, multiple studies demonstrate the opposite (sensitization) [19,22,32,45,51]. Most studies employ group-level analyses only, and simply report descriptives of the whole sample [8,36,59,73,75], or only include incomplete individual data [13,23,29,32,45,50,77].…”

Section: Introductionmentioning

confidence: 99%

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Temporal dynamics of hippocampal activity predict stable patterns of sensitization or habituation to noxious stimulation across sessions

Harrison,

van Reekum,

Adams

et al. 2023

Preprint

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Acute pain serves to warn an organism of potential damage. When nociceptive stimulation persists, two possible responses emerge: If no risk of harm is anticipated, habituation may occur. If harm is considered possible, pain sensitization is likely. An individuals adaptation to prolonged pain may provide insight into their ability to manage resources, and possibly their likelihood of developing chronic pain. Yet, little is known about the stability of these individual differences or their underlying neural mechanisms. Eighty-five participants undertook a repetitive noxious stimulation task and a resting-state scan in an MRI scanner, in a first session. They then completed the same task outside the scanner on three separate days. Pain adaptation was operationalized as the slope of change in pain ratings within session. Intraclass correlations were calculated between slopes across the four sessions, which demonstrated high stability and association with emotional disposition. Individuals who habituated to repeated stimuli showed increasing activity in the anterior hippocampus and amygdala, while individuals who sensitized showed increasing activity in the sensorimotor cortices. These clusters were then used as seeds in resting state analysis, with habituation associated with higher functional connectivity between hippocampus/amygdala and ventromedial prefrontal cortex(vmPFC), and higher connectivity between sensorimotor regions and the hippocampus, amygdala and insula cortex. Our findings suggest that pain adaptation is a stable phenotypic trait, which may have implications for the prediction of chronic pain. This study implicates neural sensory and appraisal systems in these stable responses, offering insight into the mechanisms underlying trait-like responses to prolonged nociceptive input.

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Section: Discussionmentioning

confidence: 73%

Section: Introductionmentioning

confidence: 99%

Temporal dynamics of hippocampal activity predict stable patterns of sensitization or habituation to noxious stimulation across sessions

Harrison,

van Reekum,

Adams

et al. 2023

Preprint

View full text Add to dashboard Cite

show abstract

“…Pain is defined as "an unpleasant sensory and emotional experience associated with or resembling that associated with actual or potential tissue damage" [22]. Such pain has many subjective elements, and these subjective emotions may respond sensitively to changes in the intensity of stimuli [23]. Therefore, appropriate analgesic dose changes in response to changing pain stimuli may lead to better pain control.…”

Section: Discussionmentioning

confidence: 99%

Comparison of Postoperative Pain and Adverse Effects between Variable-Rate Feedback Infusion and Conventional Fixed-Rate Basal Infusion Modes of Patient-Controlled Epidural Analgesia following Open Gastrectomy: A Randomized Controlled Trial

Jang

Kim

Lee

et al. 2021

IJERPH

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Patient-controlled epidural analgesia is widely used to control postoperative pain following major intra-abdominal surgeries. However, determining the optimal infusion dose that can produce effective analgesia while reducing side effects remains a task to be solved. Postoperative pain and adverse effects between variable-rate feedback infusion (VFIM group, n = 36) and conventional fixed-rate basal infusion (CFIM group, n = 36) of fentanyl/ropivacaine-based patient-controlled epidural analgesia were evaluated. In the CFIM group, the basal infusion rate was fixed (5 mL/h), whereas, in the VFIM group, the basal infusion rate was increased by 0.5 mL/h each time a bolus dose was administered and decreased by 0.3 mL/h when a bolus dose was not administered for 2 h. Patients in the VFIM group experienced significantly less pain at one to six hours after surgery than those in the CFIM group. Further, the number of patients who suffered from postoperative nausea was significantly lower in the VFIM group than in the CFIM group until six hours after surgery. The variable-rate feedback infusion mode of patient-controlled epidural analgesia may provide better analgesia accompanied with significantly less nausea in the early postoperative period than the conventional fixed-rate basal infusion mode following open gastrectomy.

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Mind, Body and Wellbeing: Reinforcement Sensitivity Theory and Self-cultivation Systems as Wellbeing Influencers

Sovereign

Walker

2020

J Happiness Stud

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The influence of repetitive painful stimulation on peripheral and trigeminal pain thresholds

Cited by 6 publications

References 9 publications

Temporal dynamics of hippocampal activity predict stable patterns of sensitization or habituation to noxious stimulation across sessions

Temporal dynamics of hippocampal activity predict stable patterns of sensitization or habituation to noxious stimulation across sessions

Comparison of Postoperative Pain and Adverse Effects between Variable-Rate Feedback Infusion and Conventional Fixed-Rate Basal Infusion Modes of Patient-Controlled Epidural Analgesia following Open Gastrectomy: A Randomized Controlled Trial

Mind, Body and Wellbeing: Reinforcement Sensitivity Theory and Self-cultivation Systems as Wellbeing Influencers

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