The influence of reward sensitivity, heart rate dynamics and EEG-delta activity on placebo analgesia

Pascalis, Vilfredo De; Scacchia, Paolo

doi:10.1016/j.bbr.2018.11.014

Cited by 24 publications

(41 citation statements)

References 111 publications

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“…Moreover, HRV predicted a placebo effect on negative emotions. De Pascalis and Scacchia ( 2019 ) reported lower pain and increased time-HRV with a slowed-down pace in the placebo condition, as compared with the pain-only condition. Furthermore, although the LF/HF ratio was not impacted, linear HRV measures predicted the placebo effect.…”

Section: Resultsmentioning

confidence: 99%

“…In sum, two studies showed that placebo effects decreased LF-HRV (Pollo et al, 2003 ) and that nocebo information increased LF-HRV (Chae et al, 2008 ), whereas one study showed that expectations did not affect HRV (Jegindø et al, 2013 ). Two studies showed that HRV predicted placebo responses on negative emotions and pain (Aslaksen and Flaten, 2008 ; De Pascalis and Scacchia, 2019 ). One study showed that sham meditation produced lower pain and HF-HRV (Adler-Neal et al, 2019 ).…”

Section: Resultsmentioning

confidence: 99%

“…One study showed that sham meditation produced lower pain and HF-HRV (Adler-Neal et al, 2019 ). One study reported a lower LF/HF ratio following the placebo effect (Aslaksen and Flaten, 2008 ), but two studies showed the placebo effect failed to impact the LF/HF ratio (Chae et al, 2008 ; De Pascalis and Scacchia, 2019 ) ( Table 2 ).…”

Section: Resultsmentioning

confidence: 99%

“…All six studies used power spectral analysis including time and frequency domains. Moreover, three studies analyzed the LF/HF ratio (Aslaksen and Flaten, 2008;Chae et al, 2008;De Pascalis and Scacchia, 2019); one study considered the coefficient component variance in LF and HF bands (Jegindø et al, 2013); and another study analyzed only HF-HRV (Adler-Neal et al, 2019). Pollo et al (2003) showed a decrease in LF-HRV in the placebo condition, as compared with the treatment conditions.…”

Section: Hrv and Placebo/nocebo Responsesmentioning

confidence: 99%

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Placebo Analgesia, Nocebo Hyperalgesia, and the Cardiovascular System: A Qualitative Systematic Review

Daniali

Flaten

2020

Front. Physiol.

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Background: Placebo/nocebo effects involve the autonomic nervous system, including cardiac activity, but studies have reported inconsistent findings on how cardiac activity is modulated following a placebo/nocebo effect. However, no systematic review has been conducted to provide a clear picture of cardiac placebo responses. Objective: The main goal of the present study is to review the effects of placebo analgesia and nocebo hyperalgesia on cardiac activity as measured by blood pressure, heart rate, and heart rate variability. Methods: Using several Boolean keyword combinations, the PubMed, EMBASE, PsycINFO, Cochrane Review Library, and ISI Web of Knowledge databases were searched until January 5, 2020, to find studies that analyzed blood pressure, heart rate, or heart rate variability indexes following a placebo analgesic/nocebo hyperalgesic effect. Results: Nineteen studies were found, with some reporting more than one index of cardiac activity; eight studies were on blood pressure, 14 studies on heart rate, and six on heart rate variability. No reliable association between placebo/nocebo effects and blood pressure or heart rate was found. However, placebo effects reduced, and nocebo effects increased low-frequency heart rate variability, and heart rate variability significantly predicted placebo effects in two studies. Conclusion: Placebo/nocebo effects can have reliable effects on heart rate variability, but not on heart rate and blood pressure.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Hrv and Placebo/nocebo Responsesmentioning

confidence: 99%

See 2 more Smart Citations

Placebo Analgesia, Nocebo Hyperalgesia, and the Cardiovascular System: A Qualitative Systematic Review

Daniali

Flaten

2020

Front. Physiol.

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“…Participants completed an averaged time of about 13 min of EEG recordings during two treatments with eyes open (see Figure 1). CP was induced by administration of the cold cup test (CCT; Chen, Chang, & Arendt-Nielsen, 2000;De Pascalis & Scacchia, 2019). The CCT can be considered as a variation of the ice-water cold-pressor test.…”

Section: Methodsmentioning

confidence: 99%

Changes of EEG band oscillations to tonic cold pain and the behavioral inhibition and fight-flight-freeze systems

Pascalis

Scacchia

Papi

et al. 2019

Personality Neuroscience

Self Cite

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Using electroencephalography (EEG) power measures within conventional delta, theta, alpha, beta, and gamma bands, the aims of the current study were to highlight cortical correlates of subjective perception of cold pain (CP) and the associations of these measures with behavioral inhibition system (BIS), fight-flight-freeze system (FFFS), and behavioral approach system personality traits. EEG was recorded in 55 healthy right-handed women under (i) a white noise interruption detection condition (Baseline); (ii) enduring CP induced by the cold cup test. CP and Baseline EEG band power scores within conventional frequency bands served for covariance analyses. We found that: (1) higher Pain scorers had higher EEG beta power changes at left frontal, midline central, posterior temporal leads; (2) higher BIS was associated with greater EEG delta activity changes at parietal scalp regions; (3) higher FFFS was associated with higher EEG delta activity changes at temporal and left-parietal regions, and with lower EEG gamma activity changes at right parietal regions. High FFFS, compared to Low FFFS scorers, also showed a lower gamma power across the midline, posterior temporal, and parietal regions. Results suggest a functional role of higher EEG beta activity in the subjective perception of tonic pain. EEG delta activity underpins conflict resolution system responsible for passive avoidance control of pain, while higher EEG delta and lower EEG gamma activity changes, taken together, underpin active avoidance system responsible for pain escape behavior.

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Modulation effects of imagery acupuncture and no-touch double-blinded placebo acupuncture, a cross-over pilot study

Takakura,

Sacca,

Takayama

et al. 2024

Brain Behavior and Immunity Integrative

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The influence of reward sensitivity, heart rate dynamics and EEG-delta activity on placebo analgesia

Cited by 24 publications

References 111 publications

Placebo Analgesia, Nocebo Hyperalgesia, and the Cardiovascular System: A Qualitative Systematic Review

Placebo Analgesia, Nocebo Hyperalgesia, and the Cardiovascular System: A Qualitative Systematic Review

Changes of EEG band oscillations to tonic cold pain and the behavioral inhibition and fight-flight-freeze systems

Modulation effects of imagery acupuncture and no-touch double-blinded placebo acupuncture, a cross-over pilot study

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