The Influence of Right Ventricular Afterload in Cardiac Resynchronization Therapy: A CircAdapt Study

Abstract

The individual response to cardiac resynchronization therapy (CRT) remains difficult to predict, and some research has focused on right ventricle (RV) dysfunction parameters in an effort to shed light on this problem. In a recent clinical study, researchers investigated the interaction of the RV with the pulmonary system. In this article, we analyze this issue by performing a computer simulation with the established CircAdapt model. Our results indicate that RV afterload at baseline is highly correlated with positive acute CRT response in terms of positive stroke volume (SV) and RV ejection fraction (EF) change.