The relationship between heat energy and initial fatigue life of different metals under multi-level loading stress and elevated temperature is introduced. The fatigue damage evolution model was established from the microscopic and mesoscopic perspectives to explore the fatigue damage and the crack initiation location at elevated temperature. Based on the method of continuous damage mechanics, the influence of multi-level loads on fatigue cracking life and heat energy on strain energy of distribution were investigated. The mathematical model is verified by the experimental data. The model has important engineering significance for predicting the service life of parts at elevated temperature. K E Y W O R D S elevated temperature, fatigue crack, heat energy, multi-level load, multi-scale Highlights 1. Fatigue damage model is established by the coupling of microcosmic and microcosmic.2. The relationship between heat energy and fatigue life is discussed.3. The influence of heat energy on sub-surface damage of parts was investigated.4. Considering the influence of heat energy to improve the accuracy of fatigue model.