The influence of sequential annual vaccination and of DHEA administration on the efficacy of the immune response to influenza vaccine in the elderly

Ben‐Yehuda, Arie; Danenberg, Haim; Zakay‐Rones, Zichria; Gross, D. J.; Friedman, G.

doi:10.1016/s0047-6374(98)00017-7

Cited by 29 publications

(11 citation statements)

References 17 publications

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“…These data further highlight the importance of DHEAS as hormonal adjuvant because of the role of this cytokine in the cellular response against mycobacteria. However, these animal data are in contrast to previous studies reporting DHEA(S) with minor [50] or no adjuvant effects [51][52][53] during immunization to influenza or tetanus in human elderly populations. Therefore, extrapolation from studies on murine models to the human should be regarded with caution -especially because of lower circulating DHEA(S) levels in rodents.…”

Section: Role Of Dhea During Immunosenescencecontrasting

confidence: 99%

Chronic Stress and Immunosenescence: A Review

Bauer

2008

Neuroimmunomodulation

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This paper reviews recent work suggesting that human immunosenescence may be closely related to both chronic stress and stress hormones. The age-related immunological changes are also similarly found during chronic stress or glucocorticoid exposure. These data further suggest that endogenous glucocorticoids could be associated with immunosenescence. When compared with young subjects, healthy elders are emotionally distressed in parallel to increased cortisol/dehydroepiandrosterone ratio. Furthermore, chronically stressed elderly subjects may be particularly at risk of stress-related pathology because of further alterations in glucocorticoid-immune signaling. Age-related increase in cortisol/dehydroepiandrosterone ratio could be understood as a major determinant of immunological changes observed during aging. Strictly healthy elders are somewhat protected from chronic stress exposure and show normal cortisol levels and increased T cell function. This information adds a new key dimension to the biology of aging and stress.

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Section: Role Of Dhea During Immunosenescencecontrasting

confidence: 99%

Chronic Stress and Immunosenescence: A Review

Bauer

2008

Neuroimmunomodulation

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“…HIV) diseases, and that both cortisol and DHEA/DHEAS have been proposed to have a role in regulating immune function (5,10,23,24); DHEA/DHEAS is also considered protective against the immunosuppressive actions of cortisol (7). There is also evidence that treatment with DHEA can enhance immune function in humans with low DHEA/DHEAS levels (35), and increase immune function in animals (36,37), although the benefits of DHEA supplementation on immunity in general remain controversial (6,38,39). Taken together, the data suggest that DHEA might contribute to mortality via immune function effects.…”

Section: Discussionmentioning

confidence: 99%

Cortisol, DHEA sulphate, their ratio, and all-cause and cause-specific mortality in the Vietnam Experience Study

Phillips

Carroll²,

Gale

et al. 2010

European Journal of Endocrinology

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Objectives: The aim of the present analyses was to examine the association between cortisol, DHEA sulphate (DHEAS) and the cortisol:DHEAS ratio and mortality. Design: This was a prospective cohort analysis. Methods: Participants were 4255 Vietnam-era US army veterans. From military service files, telephone interviews and a medical examination, occupational, socio-demographic and health data were collected. Contemporary morning fasted cortisol and DHEAS concentrations were determined. Mortality was tracked over the subsequent 15 years. The outcomes were all-cause, cardiovascular disease, cancer, other medical mortality and external causes of death. Cox proportional hazard models were tested, initially with adjustment for age, and then with adjustment for a range of candidate confounders. Results: In general, cortisol concentrations did not show an association with all-cause or cause-specific mortality. However, in age-adjusted and fully adjusted analyses, DHEAS was negatively related to all-cause, all cancers and other medical mortality; high DHEAS concentrations were protective. The cortisol:DHEAS ratio was also associated with these outcomes in both age-adjusted and fully adjusted models; the higher the ratio, the greater the risk of death. Conclusions: DHEAS was negatively associated, and the ratio of cortisol to DHEAS was positively associated with all-cause, cancer and other medical cause mortality. Further experimental study is needed to elucidate the mechanisms involved in these relationships.

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“…These data further highlight the importance of DHEAS as hormonal adjuvant because of the role of this cytokine in the cellular response against mycobacteria. However, these animal data are in contrast to previous studies reporting DHEA(S) with minor (Degelau et al 1997 ) or no adjuvant effects (Ben-Yehuda et al 1998 ;Danenberg et al 1997 ;Evans et al 1996 ) dur-ing immunization to influenza or tetanus in human elderly populations. Therefore, extrapolation from studies on murine models to the human should be regarded with caution-especially because of lower circulating DHEA(S) levels in rodents.…”

Section: Role Of Dhea During Immunosenescencecontrasting

confidence: 99%