The influence of serum and albumin on the constant composition growth and surface properties of calcium oxalate monohydrate

Smesko, S.A.; Singh, R. P.; Lanzalaco, A.C.; Nancollas, G.H.

doi:10.1016/0166-6622(88)80137-9

Cited by 12 publications

(5 citation statements)

References 16 publications

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“…Calcium oxalate and calcium phosphate are the principal crystalline materials found in urinary stones. , The inorganic crystals are always mixed with an organic matrix composed of carbohydrates, lipids, and proteinaceous materials that account for about 2% of the total mass, although a much larger percentage of the total volume. , It has been shown that lipid matrixes induce the in vitro precipitation of calcium oxalate from metastable solutions . In addition, there is evidence that calcium oxalate precipitation can be induced in vivo by renal epithelial cells , as well as in vitro by membrane vesicles isolated from renal brush-border membranes. , To better understand the process of stone formation, it is important to study interactions between the organic and crystalline components.…”

Section: Introductionmentioning

confidence: 99%

“…Calcium oxalate and calcium phosphate are the principal crystalline materials found in urinary stones. 1,2 The inorganic crystals are always mixed with an organic matrix composed of carbohydrates, lipids, and proteinaceous materials that account for about 2% of the total mass, although a much larger percentage of the total volume. 3,4 It has been shown that lipid matrixes induce the in vitro precipitation of calcium oxalate from metastable solutions.…”

Section: Introductionmentioning

confidence: 99%

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Brewster Angle Microscopy of Calcium Oxalate Monohydrate Precipitation at Phospholipid Monolayer Phase Boundaries

Benitez

Talham

2004

Langmuir

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The precipitation of calcium oxalate monohydrate (COM) at phospholipid monolayers confined to the air/water interface is observed in situ with the aid of Brewster angle microscopy. COM crystals appear as bright objects that are easily identified and quantified to assess the effects of different conditions on crystallization. Crystal precipitation was monitored at monolayers of 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) in liquid condensed (LC) and liquid expanded (LE) phases. Within the LC phase, higher pressures reduce the incidence of crystallization at the interface, implying that within this phase precipitation is enhanced by higher compressibility or fluidity of the monolayer. Precipitation at biphasic LC/LE and LE/gas (G) monolayers was also studied. COM appears preferentially at phase boundaries of the DPPC LC/LE and LE/G monolayers. However, when an LC/LE phase boundary is created by two different phospholipids that are phase segregated, such as DPPC and 1,2-dimyristoyl-sn-glycero-3-phosphocholine, crystal formation occurs away from the interface within the DPPC LC phase. It is suggested that COM growth at phase boundaries is preferred only when there is molecular exchange between the phases.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Brewster Angle Microscopy of Calcium Oxalate Monohydrate Precipitation at Phospholipid Monolayer Phase Boundaries

Benitez

Talham

2004

Langmuir

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“…Kidney stones, which generally describe any crystalline deposit in the urinary tract, are most commonly calcific deposits within an organic matrix. Calcium oxalate monohydrate (COM) is the predominant inorganic component of most stones, followed by calcium phosphates. , Although the bulk of the mass in a stone is from the inorganic matter, the organic matrix, including lipids, carbohydrates, and proteins, constitutes a significant volume, making the relationship between inorganic and organic components of the urinary stones important to understand. − Urine is metastable with respect to calcium oxalates and calcium phosphates, meaning that salt formation is not spontaneous in the absence of an interface . Furthermore, the transient time of urine in the kidney is quite rapid, about 3 to 4 min, which makes it unlikely for any inorganic component to grow large enough during transit to block the tubular lumen. , Stone formation, therefore, requires the heterogeneous nucleation and growth of the inorganic crystals, or crystal attachment.…”

Section: Introductionmentioning

confidence: 99%

Effect of Phospholipase A₂ Hydrolysis Products on Calcium Oxalate Precipitation at Lipid Interfaces

Sharbaugh

Talham

2009

Langmuir

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Urinary stones are commonly composed of an inorganic component, calcium oxalate, or calcium phosphate and an organic matrix of lipids, carbohydrates, and proteinaceous matter. Of interest is the role that the organic matrix elements may play as catalysts for the heterogeneous nucleation of the calcium salts, and a number of studies have examined the role of lipids in calcium oxalate monohydrate (COM) formation. In this study, products of lipid hydrolysis from phospholipase A(2) (PLA(2)) are examined for their effect on COM formation using Langmuir monolayers as model lipid membrane assemblies. The enzyme PLA(2) hydrolyzes DPPC monolayers in the presence of a supersaturated calcium oxalate subphase, inducing the rapid and plentiful nucleation of calcium oxalate at the lipid interface. To investigate the cause of increased crystal formation in the presence of the enzyme, Langmuir monolayers modeling the hydrolysis products were investigated. Calcium oxalate crystal growth at a ternary monolayer of dipalmitoylphosphatidylcholine (DPPC), palmitic acid (PA), and a 22-carbon chain lysophospholipid (22:0 Lyso PC) dramatically increases relative to monolayers of just DPPC. Binary monolayers of DPPC with either PA or the 22:0 Lyso PC and single-component monolayers of PA were also studied. It is demonstrated that the fatty acid generated during lipid hydrolysis causes a significant increase in the extent of heterogeneous nucleation of calcium oxalate from supersaturated solutions. The results imply a possible link between increased phospholipase activity, which is associated with hyperoxaluria, and calcium oxalate precipitation.

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“…A urinary stone is a product of abnormal biomineralization whose principal mineral component is calcium oxalatemonohydrate (COM),2,3 which is the thermodynamically most stable phase of CaOxa. The other two phases of CaOxa, namely calcium oxalate trihydrate (COT) and calcium oxalate dihydrate (COD), rarely form stones as they are unstable and are more easily excreted in the urine than COM.…”

Section: Introductionmentioning

confidence: 99%

The Role of Escherichia coliform in the Biomineralization of Calcium Oxalate Crystals

et al. 2007

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The influence of the common bacterium Escherichia coliform (E. coli) on the nucleation and growth of calcium oxalate (CaOxa) in aqueous solution is studied in order to determine its role in the biomineralization of urinary stones. The results show that CaOxa crystals obtained in the presence of E. coli transform more quickly from calcium oxalate dihydrate (COD) into calcium oxalate monohydrate (COM), and they become even larger, than in the absence of the bacterium. On decreasing the concentration of chemical reagents, in other words increasing the ratio bacterium/CaOxa, except for the more rapid phase transition from COD to COM, the CaOxa particles obtained become larger and more regular with a hexagonal morphology. This suggests that E. coli accelerates the crystallization of COM, which is the most stable crystal phase of CaOxa and the major component of urinary stones. Transmission electron microscopy (TEM) images, electron diffraction (ED) patterns, and Fourier-transform IR (FTIR) spectra show that the biomineralization process of

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The influence of serum and albumin on the constant composition growth and surface properties of calcium oxalate monohydrate

Cited by 12 publications

References 16 publications

Brewster Angle Microscopy of Calcium Oxalate Monohydrate Precipitation at Phospholipid Monolayer Phase Boundaries

Brewster Angle Microscopy of Calcium Oxalate Monohydrate Precipitation at Phospholipid Monolayer Phase Boundaries

Effect of Phospholipase A₂ Hydrolysis Products on Calcium Oxalate Precipitation at Lipid Interfaces

The Role of Escherichia coliform in the Biomineralization of Calcium Oxalate Crystals

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The influence of serum and albumin on the constant composition growth and surface properties of calcium oxalate monohydrate

Cited by 12 publications

References 16 publications

Brewster Angle Microscopy of Calcium Oxalate Monohydrate Precipitation at Phospholipid Monolayer Phase Boundaries

Brewster Angle Microscopy of Calcium Oxalate Monohydrate Precipitation at Phospholipid Monolayer Phase Boundaries

Effect of Phospholipase A2 Hydrolysis Products on Calcium Oxalate Precipitation at Lipid Interfaces

The Role of Escherichia coliform in the Biomineralization of Calcium Oxalate Crystals

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Effect of Phospholipase A₂ Hydrolysis Products on Calcium Oxalate Precipitation at Lipid Interfaces